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    GCH1 GTP cyclohydrolase 1 [ Panthera leo (lion) ]

    Gene ID: 122222728, updated on 22-Mar-2024

    Summary

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    Gene symbol
    GCH1
    Gene description
    GTP cyclohydrolase 1
    See related
    EnsemblRapid:ENSPLXG00005012930
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Panthera leo
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Feliformia; Felidae; Pantherinae; Panthera
    Orthologs
    human mouse all
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    Genomic context

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    See GCH1 in Genome Data Viewer
    Location:
    chromosome: B3
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    100 current P.leo_Ple1_pat1.1 (GCF_018350215.1) B3 NC_056684.1 (101752012..101834638, complement)

    Chromosome B3 - NC_056684.1Genomic Context describing neighboring genes Neighboring gene cell growth regulator with ring finger domain 1 Neighboring gene sterile alpha motif domain containing 4A Neighboring gene U6 spliceosomal RNA Neighboring gene uncharacterized LOC122222730 Neighboring gene WD repeat and HMG-box DNA binding protein 1 Neighboring gene U2 spliceosomal RNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_056684.1 Chromosome B3 Reference P.leo_Ple1_pat1.1 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    2. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables GTP cyclohydrolase I activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in tetrahydrobiopterin biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in tetrahydrofolate biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    GTP cyclohydrolase 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Panthera leo Annotation Release 100 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference P.leo_Ple1_pat1.1 Primary Assembly

    Genomic

    1. NC_056684.1 Reference P.leo_Ple1_pat1.1 Primary Assembly

      Range
      101752012..101834638 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_042943289.1 → XP_042799223.1  GTP cyclohydrolase 1 isoform X2

      Conserved Domains (1) summary
      cl00263
      Location:122 → 236
      TFold; Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl ...

    2. XM_042943288.1 → XP_042799222.1  GTP cyclohydrolase 1 isoform X1

      Conserved Domains (1) summary
      cd00642
      Location:65 → 228
      GTP_cyclohydro1; GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In ...

    3. XM_042943291.1 → XP_042799225.1  GTP cyclohydrolase 1 isoform X4

      UniProtKB/TrEMBL
      A0A8C8WK83
      Related
      ENSPLXP00005016499.1, ENSPLXT00005026741.1
      Conserved Domains (1) summary
      cd00642
      Location:65 → 208
      GTP_cyclohydro1; GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In ...

    4. XM_042943290.1 → XP_042799224.1  GTP cyclohydrolase 1 isoform X3

      UniProtKB/TrEMBL
      A0A8C8WK83, A0A8C8WM48
      Conserved Domains (1) summary
      cd00642
      Location:65 → 249
      GTP_cyclohydro1; GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In ...
    Nucleotide Protein
    Heading Accession and Version

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