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    NCF2 neutrophil cytosolic factor 2 [ Lagopus leucura (white-tailed ptarmigan) ]

    Gene ID: 122181282, updated on 22-Mar-2024

    Summary

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    Gene symbol
    NCF2
    Gene description
    neutrophil cytosolic factor 2
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Lagopus leucura
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Tetraoninae; Lagopus
    Orthologs
    human mouse all
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    Genomic context

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    See NCF2 in Genome Data Viewer
    Location:
    chromosome: Un
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    100 current USGS_WTPT01 (GCF_019238085.1) Unplaced Scaffold NW_024962266.1 (2649080..2656060)

    NW_024962266.1Genomic Context describing neighboring genes Neighboring gene apolipoprotein B mRNA editing enzyme catalytic polypeptide like 4 Neighboring gene actin related protein 2/3 complex subunit 5 Neighboring gene SMG7 nonsense mediated mRNA decay factor Neighboring gene nicotinamide nucleotide adenylyltransferase 2

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NW_024962266 Unplaced Scaffold Reference USGS_WTPT01

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    2. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables protein binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables superoxide-generating NADPH oxidase activator activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in phagocytosis IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in respiratory burst IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in superoxide anion generation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of NADPH oxidase complex IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    neutrophil cytosol factor 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Lagopus leucura Annotation Release 100 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference USGS_WTPT01

    Genomic

    1. NW_024962266.1 Reference USGS_WTPT01

      Range
      2649080..2656060
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_042873685.1 → XP_042729619.1  neutrophil cytosol factor 2 isoform X2

      Conserved Domains (5) summary
      cd06406
      Location:354 → 433
      PB1_P67; A PB1 domain is present in p67 proteins which forms a signaling complex with p40, a crucial step for activation of NADPH oxidase during phagocytosis. PB1 domain is a modular domain mediating specific protein-protein interactions which play a role in ...
      cd11871
      Location:244 → 297
      SH3_p67phox_N; N-terminal (or first) Src Homology 3 domain of the p67phox subunit of NADPH oxidase
      cd12046
      Location:458 → 510
      SH3_p67phox_C; C-terminal (or second) Src Homology 3 domain of the p67phox subunit of NADPH oxidase
      COG0457
      Location:9 → 173
      TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
      sd00006
      Location:37 → 65
      TPR; TPR repeat [structural motif]

    2. XM_042873684.1 → XP_042729618.1  neutrophil cytosol factor 2 isoform X1

      Conserved Domains (5) summary
      cd06406
      Location:354 → 433
      PB1_P67; A PB1 domain is present in p67 proteins which forms a signaling complex with p40, a crucial step for activation of NADPH oxidase during phagocytosis. PB1 domain is a modular domain mediating specific protein-protein interactions which play a role in ...
      cd11871
      Location:244 → 297
      SH3_p67phox_N; N-terminal (or first) Src Homology 3 domain of the p67phox subunit of NADPH oxidase
      COG0457
      Location:9 → 173
      TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
      sd00006
      Location:37 → 65
      TPR; TPR repeat [structural motif]
      cl17036
      Location:458 → 488
      SH3; Src Homology 3 domain superfamily
    Nucleotide Protein
    Heading Accession and Version

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