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    LOC118422080 guanine nucleotide exchange factor VAV2-like [ Branchiostoma floridae (Florida lancelet) ]

    Gene ID: 118422080, updated on 14-Dec-2023

    Summary

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    Gene symbol
    LOC118422080
    Gene description
    guanine nucleotide exchange factor VAV2-like
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Branchiostoma floridae
    Lineage
    Eukaryota; Metazoa; Chordata; Cephalochordata; Leptocardii; Amphioxiformes; Branchiostomatidae; Branchiostoma
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    Genomic context

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    See LOC118422080 in Genome Data Viewer
    Location:
    chromosome: 8
    Exon count:
    32
    Annotation release Status Assembly Chr Location
    100 current Bfl_VNyyK (GCF_000003815.2) 8 NC_049986.1 (11516146..11549734, complement)

    Chromosome 8 - NC_049986.1Genomic Context describing neighboring genes Neighboring gene noelin-2-like Neighboring gene zinc finger protein 2-like Neighboring gene E3 ubiquitin-protein ligase COP1-like Neighboring gene collagen alpha-1(II) chain-like

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_049986.1 Chromosome 8 Reference Bfl_VNyyK Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Conserved Noncoding Elements in the Most Distant Genera of Cephalochordates: The Goldilocks Principle. Yue JX, et al. Genome Biol Evol, 2016 Aug 25. PMID 27412606, Free PMC Article
    2. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables guanyl-nucleotide exchange factor activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables protein binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cell migration IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in regulation of GTPase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    guanine nucleotide exchange factor VAV2-like

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Branchiostoma floridae Annotation Release 100 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Bfl_VNyyK Primary Assembly

    Genomic

    1. NC_049986.1 Reference Bfl_VNyyK Primary Assembly

      Range
      11516146..11549734 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_035829603.1 → XP_035685496.1  guanine nucleotide exchange factor VAV2-like isoform X3

      UniProtKB/TrEMBL
      A0A9J7LM75
      Conserved Domains (6) summary
      cd00160
      Location:196 → 392
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd21201
      Location:2 → 118
      CH_VAV; calponin homology (CH) domain found in VAV proteins
      cd20810
      Location:560 → 611
      C1_VAV; protein kinase C conserved region 1 (C1 domain) found in VAV proteins
      cl15255
      Location:770 → 869
      SH2; Src homology 2 (SH2) domain
      cl17036
      Location:904 → 960
      SH3; Src Homology 3 domain superfamily
      cl17171
      Location:410 → 551
      PH-like; Pleckstrin homology-like domain

    2. XM_035829605.1 → XP_035685498.1  guanine nucleotide exchange factor VAV2-like isoform X5

      UniProtKB/TrEMBL
      A0A9J7LM80
      Conserved Domains (6) summary
      cd00160
      Location:196 → 396
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd01223
      Location:414 → 541
      PH_Vav; Vav pleckstrin homology (PH) domain
      cd21201
      Location:2 → 118
      CH_VAV; calponin homology (CH) domain found in VAV proteins
      cd20810
      Location:550 → 601
      C1_VAV; protein kinase C conserved region 1 (C1 domain) found in VAV proteins
      cl15255
      Location:760 → 859
      SH2; Src homology 2 (SH2) domain
      cl17036
      Location:894 → 950
      SH3; Src Homology 3 domain superfamily

    3. XM_035829601.1 → XP_035685494.1  guanine nucleotide exchange factor VAV2-like isoform X1

      UniProtKB/TrEMBL
      A0A9J7LM76
      Conserved Domains (6) summary
      cd00160
      Location:196 → 396
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd21201
      Location:2 → 118
      CH_VAV; calponin homology (CH) domain found in VAV proteins
      cd20810
      Location:564 → 615
      C1_VAV; protein kinase C conserved region 1 (C1 domain) found in VAV proteins
      cl15255
      Location:774 → 873
      SH2; Src homology 2 (SH2) domain
      cl17036
      Location:908 → 964
      SH3; Src Homology 3 domain superfamily
      cl17171
      Location:414 → 555
      PH-like; Pleckstrin homology-like domain

    4. XM_035829604.1 → XP_035685497.1  guanine nucleotide exchange factor VAV2-like isoform X4

      UniProtKB/TrEMBL
      A0A9J7LMU5
      Conserved Domains (7) summary
      PHA03247
      Location:613 → 787
      PHA03247; large tegument protein UL36; Provisional
      cd00160
      Location:196 → 396
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd21201
      Location:2 → 118
      CH_VAV; calponin homology (CH) domain found in VAV proteins
      cd20810
      Location:564 → 615
      C1_VAV; protein kinase C conserved region 1 (C1 domain) found in VAV proteins
      cl15255
      Location:766 → 864
      SH2; Src homology 2 (SH2) domain
      cl17036
      Location:899 → 955
      SH3; Src Homology 3 domain superfamily
      cl17171
      Location:414 → 555
      PH-like; Pleckstrin homology-like domain

    5. XM_035829602.1 → XP_035685495.1  guanine nucleotide exchange factor VAV2-like isoform X2

      UniProtKB/TrEMBL
      A0A9J7LQQ2
      Conserved Domains (6) summary
      cd00160
      Location:196 → 396
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd21201
      Location:2 → 118
      CH_VAV; calponin homology (CH) domain found in VAV proteins
      cd20810
      Location:564 → 615
      C1_VAV; protein kinase C conserved region 1 (C1 domain) found in VAV proteins
      cl15255
      Location:771 → 869
      SH2; Src homology 2 (SH2) domain
      cl17036
      Location:904 → 960
      SH3; Src Homology 3 domain superfamily
      cl17171
      Location:414 → 555
      PH-like; Pleckstrin homology-like domain

    6. XM_035829606.1 → XP_035685499.1  guanine nucleotide exchange factor VAV2-like isoform X6

      UniProtKB/TrEMBL
      A0A9J7LPD4
      Conserved Domains (6) summary
      cd00160
      Location:196 → 377
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd21201
      Location:2 → 118
      CH_VAV; calponin homology (CH) domain found in VAV proteins
      cd20810
      Location:545 → 596
      C1_VAV; protein kinase C conserved region 1 (C1 domain) found in VAV proteins
      cl15255
      Location:755 → 854
      SH2; Src homology 2 (SH2) domain
      cl17036
      Location:889 → 945
      SH3; Src Homology 3 domain superfamily
      cl17171
      Location:395 → 536
      PH-like; Pleckstrin homology-like domain
    Nucleotide Protein Strain
    Heading Accession and Version

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