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    Fer FER tyrosine kinase [ Rattus rattus (black rat) ]

    Gene ID: 116899691, updated on 18-Mar-2024

    Summary

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    Gene symbol
    Fer
    Gene description
    FER tyrosine kinase
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Rattus rattus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Orthologs
    human mouse all
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    Genomic context

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    See Fer in Genome Data Viewer
    Location:
    chromosome: 4
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    100 current Rrattus_CSIRO_v1 (GCF_011064425.1) 4 NC_046157.1 (173988298..174240354)

    Chromosome 4 - NC_046157.1Genomic Context describing neighboring genes Neighboring gene tubulin alpha-1 chain-like Neighboring gene F-box and leucine rich repeat protein 17 Neighboring gene small nucleolar RNA SNORA17 Neighboring gene U6 spliceosomal RNA Neighboring gene praja ring finger ubiquitin ligase 2

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_046157.1 Chromosome 4 Reference Rrattus_CSIRO_v1 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Novel protein-tyrosine kinase cDNAs related to fps/fes and eph cloned using anti-phosphotyrosine antibody. Letwin K, et al. Oncogene, 1988 Dec. PMID 2485255
    2. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables non-membrane spanning protein tyrosine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in Fc-epsilon receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in cell adhesion IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in chemotaxis IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in peptidyl-tyrosine phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in regulation of mast cell degranulation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    LOW QUALITY PROTEIN: tyrosine-protein kinase Fer
    Names
    flk protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Rattus rattus Annotation Release 100 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Rrattus_CSIRO_v1 Primary Assembly

    Genomic

    1. NC_046157.1 Reference Rrattus_CSIRO_v1 Primary Assembly

      Range
      173988298..174240354
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_032901714.1 → XP_032757605.1  LOW QUALITY PROTEIN: tyrosine-protein kinase Fer

      Conserved Domains (3) summary
      cd07686
      Location:5 → 238
      F-BAR_Fer; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Fer (Fes related) tyrosine kinase
      cd10361
      Location:454 → 539
      SH2_Fps_family; Src homology 2 (SH2) domain found in feline sarcoma, Fujinami poultry sarcoma, and fes-related (Fes/Fps/Fer) proteins
      cl21453
      Location:567 → 817
      PKc_like; Protein Kinases, catalytic domain
    Nucleotide Protein
    Heading Accession and Version

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