Dlgap2 DLG associated protein 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Dlgap2provided by RGD
Official Full Name: DLG associated protein 2provided by RGD
Primary source: RGD:620224
See related: EnsemblRapid:ENSRNOG00000012573 AllianceGenome:RGD:620224
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: DAP-2; SAPAP2
Summary: The product of this gene is a membrane-associated protein that may play a role in synapse organization and signalling in neuronal cells. [provided by RefSeq, Jun 2014]
Expression: Restricted expression toward (RPKM 70.0) See more
Orthologs: human mouse all
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Genomic context

Location:: 16q12.5

Exon count:: 18

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	16	NC_086034.1 (81489059..82198693, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	16	NC_051351.1 (74786771..75496402, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	16	NC_005115.4 (79872238..80596977, complement)

Chromosome 16 - NC_086034.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Oligomeric Abeta25-35 induces the tyrosine phosphorylation of PSD-95 by SrcPTKs in rat hippocampal CA1 subfield.
Title: Oligomeric Aβ25-35 induces the tyrosine phosphorylation of PSD-95 by SrcPTKs in rat hippocampal CA1 subfield.
Protein kinase A-phosphorylated KV1 channels in PSD95 signaling complex contribute to the resting membrane potential and diameter of cerebral arteries.
Title: Protein kinase A-phosphorylated KV1 channels in PSD95 signaling complex contribute to the resting membrane potential and diameter of cerebral arteries.
These results suggest that alterations in global methylation pattern are involved in behavioural adaptation to environmental stress and pinpoint Dlgap2 as a possible target in post-traumatic stress.
Title: DNA methylation in vulnerability to post-traumatic stress in rats: evidence for the role of the post-synaptic density protein Dlgap2.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

d16rat48 (e-PCR)
- UniSTS:121149

D16Got84 (e-PCR)
- UniSTS:116059

32.MMHAP64FRC11.seq (e-PCR)
- UniSTS:123995

D16Got89 (e-PCR)
- UniSTS:114566

D16Rat15 (e-PCR)
- UniSTS:119481

RH144459 (e-PCR)
- UniSTS:233704

RH138324 (e-PCR)
- UniSTS:220411

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables guanylate kinase activity	NAS Non-traceable Author Statement more info
enables molecular adaptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein domain specific binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in GDP metabolic process	IEA Inferred from Electronic Annotation more info
involved_in GMP metabolic process	IEA Inferred from Electronic Annotation more info
involved_in modulation of chemical synaptic transmission	IBA Inferred from Biological aspect of Ancestor more info
involved_in modulation of chemical synaptic transmission	ISO Inferred from Sequence Orthology more info
involved_in neuron-neuron synaptic transmission	NAS Non-traceable Author Statement more info	PubMed
involved_in regulation of postsynaptic neurotransmitter receptor activity	ISO Inferred from Sequence Orthology more info
involved_in signaling	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in dendrite	IDA Inferred from Direct Assay more info
located_in dendritic spine	IDA Inferred from Direct Assay more info	PubMed
is_active_in glutamatergic synapse	IBA Inferred from Biological aspect of Ancestor more info
is_active_in glutamatergic synapse	ISO Inferred from Sequence Orthology more info
located_in neurofilament	NAS Non-traceable Author Statement more info	PubMed
is_active_in postsynaptic density, intracellular component	ISO Inferred from Sequence Orthology more info
located_in postsynaptic membrane	NAS Non-traceable Author Statement more info
is_active_in postsynaptic specialization	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: disks large-associated protein 2

Names: PSD-95/SAP90-associated protein-2; PSD-95/SAP90-binding protein 2; SAP90/PSD-95-associated protein 2; discs large homolog associated protein 2; postsynaptic density 95

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_053901.2 → NP_446353.3 disks large-associated protein 2

Status: VALIDATED

Source sequence(s)

JAXUCZ010000016

UniProtKB/Swiss-Prot

P97837

UniProtKB/TrEMBL

A0A8I5ZQT2

Related

ENSRNOP00000104191.1, ENSRNOT00000138999.1

Conserved Domains (1) summary

pfam03359
Location:715 → 1059

GKAP; Guanylate-kinase-associated protein (GKAP) protein

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086034.1 Reference GRCr8

Range

81489059..82198693 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039094154.2 → XP_038950082.1 disks large-associated protein 2 isoform X1

UniProtKB/Swiss-Prot

P97837

UniProtKB/TrEMBL

A0A0G2JUI3

Related

ENSRNOP00000069108.2, ENSRNOT00000086896.3

Conserved Domains (1) summary

pfam03359
Location:716 → 1060

GKAP; Guanylate-kinase-associated protein (GKAP) protein
XM_039094157.2 → XP_038950085.1 disks large-associated protein 2 isoform X4

UniProtKB/TrEMBL

A0A8I6A4U6

Conserved Domains (1) summary

pfam03359
Location:716 → 1046

GKAP; Guanylate-kinase-associated protein (GKAP) protein
XM_039094156.2 → XP_038950084.1 disks large-associated protein 2 isoform X3

UniProtKB/TrEMBL

A6IWE1, F1LSL6

Related

ENSRNOP00000107136.1, ENSRNOT00000126131.1

Conserved Domains (1) summary

pfam03359
Location:703 → 1047

GKAP; Guanylate-kinase-associated protein (GKAP) protein
XM_063275039.1 → XP_063131109.1 disks large-associated protein 2 isoform X2

UniProtKB/TrEMBL

F1LSL6

Related

ENSRNOP00000111868.1, ENSRNOT00000162694.1