Aldh1a2 aldehyde dehydrogenase 1 family, member A2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Aldh1a2provided by RGD
Official Full Name: aldehyde dehydrogenase 1 family, member A2provided by RGD
Primary source: RGD:620250
See related: EnsemblRapid:ENSRNOG00000055049 AllianceGenome:RGD:620250
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Raldh-2
Summary: Enables retinal binding activity and retinal dehydrogenase activity. Involved in several processes, including response to estradiol; response to vitamin A; and retinoic acid biosynthetic process. Located in perinuclear region of cytoplasm. Human ortholog(s) of this gene implicated in congenital diaphragmatic hernia. Orthologous to human ALDH1A2 (aldehyde dehydrogenase 1 family member A2). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Uterus (RPKM 140.0), Testes (RPKM 134.8) and 8 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 8q24

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	8	NC_086026.1 (80758641..80837891)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	8	NC_051343.1 (71877850..71957107)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	8	NC_005107.4 (77640234..77719488)

Chromosome 8 - NC_086026.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

This study is the first to show that RALDH2 and RALDH3, but not RALDH1, are expressed in the embryonic anterior pituitary gland of the rat.
Title: Expression of retinaldehyde dehydrogenase (RALDH)2 and RALDH3 but not RALDH1 in the developing anterior pituitary glands of rats.
inhibited by compounds that induce congenital diaphragmatic hernias (CDH); data provide an important component of mounting evidence suggesting that the retinoid system warrants consideration in future studies of the etiology of CDH.
Title: Retinal dehydrogenase-2 is inhibited by compounds that induce congenital diaphragmatic hernias in rodents.
Results suggest that postnatal expressions of hepatocyte-specific genes might be up-regulated by retinoid receptors, which may be related with the alterations of RALDH expression during postnatal development in the liver.
Title: Postnatal changes in gene expression of retinal dehydrogenase and retinoid receptors in liver of rats.
eRolDH and RalDH II and their mRNAs were increased in uteri of rats during estrus. RalDH II was observed in the stromal compartment, particularly in cells close to the uterine lumenal epithelium.
Title: Estrogen directly induces expression of retinoic acid biosynthetic enzymes, compartmentalized between the epithelium and underlying stromal cells in rat uterus.

Submit: New GeneRIF Correction

General gene information

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Markers

Aldh1a2 (e-PCR), detects polymorphism
- UniSTS:545888

Aldh1a2 (e-PCR), detects polymorphism
- UniSTS:186489

D8Wox20 (e-PCR)
- UniSTS:119419

Aldh1a2 (e-PCR), detects polymorphism
- UniSTS:498364

Aldh1a2 (e-PCR), detects polymorphism
- UniSTS:498365

RH133490 (e-PCR)
- UniSTS:216773

Aldh1a2 (e-PCR), detects polymorphism
- UniSTS:166623

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables 3-chloroallyl aldehyde dehydrogenase activity	ISO Inferred from Sequence Orthology more info
enables aldehyde dehydrogenase (NAD+) activity	IBA Inferred from Biological aspect of Ancestor more info
enables oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor	IEA Inferred from Electronic Annotation more info
enables retinal binding	IDA Inferred from Direct Assay more info	PubMed
enables retinal dehydrogenase activity	IDA Inferred from Direct Assay more info	PubMed
enables retinal dehydrogenase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within 9-cis-retinoic acid biosynthetic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within anterior/posterior pattern specification	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within blood vessel development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within camera-type eye development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cardiac muscle tissue development	ISO Inferred from Sequence Orthology more info
acts_upstream_of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in cellular response to retinoic acid	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within determination of bilateral symmetry	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within embryonic camera-type eye development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within embryonic digestive tract development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within embryonic forelimb morphogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within embryonic limb morphogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within face development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within forebrain development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within heart morphogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within hindbrain development	ISO Inferred from Sequence Orthology more info
involved_in kidney development	IEP Inferred from Expression Pattern more info	PubMed
involved_in lipid metabolic process	IEA Inferred from Electronic Annotation more info
involved_in liver development	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within lung development	ISO Inferred from Sequence Orthology more info
involved_in midgut development	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within morphogenesis of embryonic epithelium	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within neural crest cell development	ISO Inferred from Sequence Orthology more info
involved_in neural tube development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within neuron differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within pancreas development	ISO Inferred from Sequence Orthology more info
involved_in pituitary gland development	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within positive regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in protein homotetramerization	ISO Inferred from Sequence Orthology more info
involved_in protein homotetramerization	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within proximal/distal pattern formation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of vascular endothelial cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in response to cytokine	ISO Inferred from Sequence Orthology more info
involved_in response to estradiol	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to retinoic acid	ISO Inferred from Sequence Orthology more info
involved_in response to retinoic acid	ISS Inferred from Sequence or Structural Similarity more info
involved_in response to vitamin A	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within retinal metabolic process	ISO Inferred from Sequence Orthology more info
involved_in retinoic acid biosynthetic process	IEP Inferred from Expression Pattern more info	PubMed
involved_in retinoic acid biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in retinoic acid biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in retinoic acid biosynthetic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in retinoic acid metabolic process	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within retinoic acid metabolic process	ISO Inferred from Sequence Orthology more info
involved_in retinoic acid metabolic process	ISO Inferred from Sequence Orthology more info
involved_in retinoic acid metabolic process	TAS Traceable Author Statement more info	PubMed
acts_upstream_of_or_within retinoic acid receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in retinol metabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within ureter maturation	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in perinuclear region of cytoplasm	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: retinal dehydrogenase 2

Names: RALDH 2; RalDH(II); aldehyde dehydrogenase 1A2; aldehyde dehydrogenase family 1 member A2; aldehyde dehydrogenase family 1, subfamily A2; ralDH2; retinal dehydrogenase, type II; retinaldehyde-specific dehydrogenase type 2

NP_446348.2

EC 1.2.1.36

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_053896.2 → NP_446348.2 retinal dehydrogenase 2

Status: VALIDATED

Source sequence(s)

BC098910, BE111477, EV764818

UniProtKB/Swiss-Prot

Q4FZY8, Q63639

UniProtKB/TrEMBL

A0A8I5Y0L7, A6KER4

Related

ENSRNOP00000073203.1, ENSRNOT00000079115.3

Conserved Domains (1) summary

cd07141
Location:32 → 512

ALDH_F1AB_F2_RALDH1; NAD+-dependent retinal dehydrogenase 1, ALDH families 1A, 1B, and 2-like