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    MRGPRF MAS related GPR family member F [ Homo sapiens (human) ]

    Gene ID: 116535, updated on 10-Dec-2024

    Summary

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    Official Symbol
    MRGPRFprovided by HGNC
    Official Full Name
    MAS related GPR family member Fprovided by HGNC
    Primary source
    HGNC:HGNC:24828
    See related
    Ensembl:ENSG00000172935 MIM:607233; AllianceGenome:HGNC:24828
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    RTA; MRGF; GPR140; GPR168
    Summary
    Predicted to enable G protein-coupled receptor activity. Predicted to be involved in G protein-coupled receptor signaling pathway. Located in nuclear membrane and plasma membrane. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in endometrium (RPKM 20.4), prostate (RPKM 13.8) and 18 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See MRGPRF in Genome Data Viewer
    Location:
    11q13.3
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (69004398..69013633, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (69014626..69023860, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (68771866..68780714, complement)

    Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:68671173-68671900 Neighboring gene immunoglobulin mu DNA binding protein 2 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5147 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5148 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr11:68701479-68702678 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:68714105-68714968 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3686 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5149 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:68747435-68747944 Neighboring gene ReSE screen-validated silencer GRCh37_chr11:68762134-68762300 Neighboring gene MAS related GPR family member D Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:68769878-68770378 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:68771339-68771840 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:68775087-68775794 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr11:68775901-68777100 Neighboring gene MRGPRF antisense RNA 1 Neighboring gene uncharacterized LOC124902701 Neighboring gene uncharacterized LOC124902702 Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:68807523-68808024 Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:68808025-68808524 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:68811813-68812480 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3687 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3688 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3689 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:68818804-68819378 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:68820529-68821102 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5150 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5151 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5152 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:68833413-68834165 Neighboring gene two pore segment channel 2 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr11:68847233-68848432 Neighboring gene microRNA 3164

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. The orphan MRGPRF receptor is expressed in entero-endocrine cells of the human gut mucosa. Van Remoortel S, et al. Cell Tissue Res, 2023 Aug. PMID 37314493
    2. RTA, a candidate G protein-coupled receptor: cloning, sequencing, and tissue distribution. Ross PC, et al. Proc Natl Acad Sci U S A, 1990 Apr. PMID 2109324, Free PMC Article
    3. A diverse family of GPCRs expressed in specific subsets of nociceptive sensory neurons. Dong X, et al. Cell, 2001 Sep 7. PMID 11551509
    4. Comparative genomic analysis of eutherian Mas-related G protein-coupled receptor genes. Premzl M. Gene, 2014 Apr 25. PMID 24583173
    5. Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries. Otsuki T, et al. DNA Res, 2005. PMID 16303743

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ16111, FLJ29034, FLJ40998, FLJ53714, MGC21621, DKFZp586B2122

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables G protein-coupled receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in nuclear membrane IDA
    Inferred from Direct Assay
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		  

    General protein information

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    Preferred Names
    mas-related G-protein coupled receptor member F
    Names
    G protein-coupled receptor MrgF
    G-protein coupled receptor 140
    G-protein coupled receptor 168
    MAS-related GPR, member F
    Mas-related G protein-coupled receptor F
    mas-related G protein-coupled MRGF
    mas-related gene F protein
    seven transmembrane helix receptor

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001098515.2 → NP_001091985.1  mas-related G-protein coupled receptor member F

      See identical proteins and their annotated locations for NP_001091985.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AK122669, BC016964
      Consensus CDS
      CCDS8188.1
      UniProtKB/Swiss-Prot
      B3KV43, Q8NBK8, Q96AM1
      UniProtKB/TrEMBL
      A0A2I4R878
      Conserved Domains (1) summary
      cd15109
      Location:45 → 318
      7tmA_MrgprF; mas-related G protein-coupled receptor subtype F, member of the class A family of seven-transmembrane G protein-coupled receptors

    2. NM_145015.5 → NP_659452.3  mas-related G-protein coupled receptor member F

      See identical proteins and their annotated locations for NP_659452.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses a different splice site in the 5' UTR, compared to variant 1. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      BC016964, BP376260
      Consensus CDS
      CCDS8188.1
      UniProtKB/Swiss-Prot
      B3KV43, Q8NBK8, Q96AM1
      UniProtKB/TrEMBL
      A0A2I4R878
      Related
      ENSP00000309782.6, ENST00000309099.7
      Conserved Domains (1) summary
      cd15109
      Location:45 → 318
      7tmA_MrgprF; mas-related G protein-coupled receptor subtype F, member of the class A family of seven-transmembrane G protein-coupled receptors

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

      Range
      69004398..69013633 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_024448339.2 → XP_024304107.1  mas-related G-protein coupled receptor member F isoform X1

      UniProtKB/Swiss-Prot
      B3KV43, Q8NBK8, Q96AM1
      UniProtKB/TrEMBL
      A0A2I4R878
      Conserved Domains (1) summary
      cd15109
      Location:45 → 318
      7tmA_MrgprF; mas-related G protein-coupled receptor subtype F, member of the class A family of seven-transmembrane G protein-coupled receptors

    2. XM_017017170.2 → XP_016872659.1  mas-related G-protein coupled receptor member F isoform X1

      UniProtKB/Swiss-Prot
      B3KV43, Q8NBK8, Q96AM1
      UniProtKB/TrEMBL
      A0A2I4R878
      Conserved Domains (1) summary
      cd15109
      Location:45 → 318
      7tmA_MrgprF; mas-related G protein-coupled receptor subtype F, member of the class A family of seven-transmembrane G protein-coupled receptors

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060935.1 Alternate T2T-CHM13v2.0

      Range
      69014626..69023860 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054367607.1 → XP_054223582.1  mas-related G-protein coupled receptor member F isoform X1

      UniProtKB/Swiss-Prot
      B3KV43, Q8NBK8, Q96AM1
      UniProtKB/TrEMBL
      A0A2I4R878

    2. XM_054367606.1 → XP_054223581.1  mas-related G-protein coupled receptor member F isoform X1

      UniProtKB/Swiss-Prot
      B3KV43, Q8NBK8, Q96AM1
      UniProtKB/TrEMBL
      A0A2I4R878
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q96AM1.1 GenPept UniProtKB/Swiss-Prot:Q96AM1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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