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    Mprip myosin phosphatase Rho interacting protein [ Rattus norvegicus (Norway rat) ]

    Gene ID: 116504, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Mpripprovided by RGD
    Official Full Name
    myosin phosphatase Rho interacting proteinprovided by RGD
    Primary source
    RGD:619947
    See related
    EnsemblRapid:ENSRNOG00000003226 AllianceGenome:RGD:619947
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Mrip; M-rip; Rhoip3; p116Rip
    Summary
    Predicted to enable actin filament binding activity. Involved in maintenance of protein location in cell and protein dephosphorylation. Located in stress fiber. Orthologous to human MPRIP (myosin phosphatase Rho interacting protein). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Lung (RPKM 366.3), Brain (RPKM 254.0) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Mprip in Genome Data Viewer
    Location:
    10q22
    Exon count:
    26
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (44953472..45073388)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (44453949..44573843)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (46018397..46133580)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene olfactory receptor family 2 subfamily W member 25, pseudogene 1 Neighboring gene ribosomal protein L15, pseudogene 6 Neighboring gene uncharacterized LOC120095110 Neighboring gene phospholipase D family, member 6 Neighboring gene folliculin

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Differential neuronal expression of receptor interacting protein 3 in rat retina: involvement in ischemic stress response. Huang JF, et al. BMC Neurosci, 2013 Feb 2. PMID 23374330, Free PMC Article
    2. RIP3 Inhibition ameliorates chronic constriction injury-induced neuropathic pain by suppressing JNK signaling. He N, et al. Aging (Albany NY), 2021 Nov 12. PMID 34772825, Free PMC Article
    3. Impaired insulin-stimulated myosin phosphatase Rho-interacting protein signaling in diabetic Goto-Kakizaki vascular smooth muscle cells. Lee JH, et al. Am J Physiol Cell Physiol, 2012 May 1. PMID 22322972, Free PMC Article
    4. Targeting by myosin phosphatase-RhoA interacting protein mediates RhoA/ROCK regulation of myosin phosphatase. Riddick N, et al. J Cell Biochem, 2008 Mar 1. PMID 17661354
    5. p116Rip is a novel filamentous actin-binding protein. Mulder J, et al. J Biol Chem, 2003 Jul 18. PMID 12732640

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Role of the RIP3-PGAM5-Drp1 pathway in aluminum-induced PC12 cells necroptosis.
      Title: Role of the RIP3-PGAM5-Drp1 pathway in aluminum-induced PC12 cells necroptosis.
    2. RIP3 Inhibition ameliorates chronic constriction injury-induced neuropathic pain by suppressing JNK signaling.
      Title: RIP3 Inhibition ameliorates chronic constriction injury-induced neuropathic pain by suppressing JNK signaling.
    3. The results indicated that RIP3 is expressed differentially in retinal neurons in adult rats, including subsets of ganglion cells, amacrine and horizontal cells. RIP3 protein levels are elevated rapidly following aHIOP
      Title: Differential neuronal expression of receptor interacting protein 3 in rat retina: involvement in ischemic stress response.
    4. decreased insulin-stimulated MRIP/MYPT1 association may contribute to the impaired insulin-mediated vasodilation observed in the diabetic vasculature
      Title: Impaired insulin-stimulated myosin phosphatase Rho-interacting protein signaling in diabetic Goto-Kakizaki vascular smooth muscle cells.
    5. myosin phosphatase-rho interacting protein is a scaffold linking RhoA to regulate myosin phosphatase at the stress fiber.
      Title: Targeting by myosin phosphatase-RhoA interacting protein mediates RhoA/ROCK regulation of myosin phosphatase.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC114284

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables actin filament binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in maintenance of protein location in cell IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein dephosphorylation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in actin cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in actin cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in actin cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in stress fiber IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    myosin phosphatase Rho-interacting protein
    Names
    RIP3
    Rho interacting protein 3
    rho-interacting protein 3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001034022.2 → NP_001029194.1  myosin phosphatase Rho-interacting protein isoform 3

      See identical proteins and their annotated locations for NP_001029194.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000010
      UniProtKB/Swiss-Prot
      Q4KM03, Q9ERE6
      Conserved Domains (3) summary
      cd01236
      Location:16 → 151
      PH_RIP; Rho-Interacting Protein Pleckstrin homology (PH) domain
      cd13275
      Location:358 → 459
      PH_M-RIP; Myosin phosphatase-RhoA Interacting Protein Pleckstrin homology (PH) domain
      TIGR02168
      Location:631 → 941
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type

    2. NM_001371051.2 → NP_001357980.1  myosin phosphatase Rho-interacting protein isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000010
      UniProtKB/TrEMBL
      A0A8I5ZXY0, A0A8I6A006
      Related
      ENSRNOP00000084454.1, ENSRNOT00000100281.2
      Conserved Domains (4) summary
      COG1196
      Location:932 → 1219
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd01236
      Location:16 → 151
      PH_RIP; Rho-Interacting Protein Pleckstrin homology (PH) domain
      cd13275
      Location:512 → 613
      PH_M-RIP; Myosin phosphatase-RhoA Interacting Protein Pleckstrin homology (PH) domain
      TIGR02168
      Location:771 → 1065
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type

    3. NM_001414223.1 → NP_001401152.1  myosin phosphatase Rho-interacting protein isoform 4

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000010
      Related
      ENSRNOP00000069198.3, ENSRNOT00000080666.3

    4. NM_053814.3 → NP_446266.2  myosin phosphatase Rho-interacting protein isoform 2

      See identical proteins and their annotated locations for NP_446266.2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000010
      UniProtKB/Swiss-Prot
      Q4KM03, Q9ERE6
      UniProtKB/TrEMBL
      A6HF15
      Conserved Domains (3) summary
      cd01236
      Location:16 → 151
      PH_RIP; Rho-Interacting Protein Pleckstrin homology (PH) domain
      cd13275
      Location:394 → 495
      PH_M-RIP; Myosin phosphatase-RhoA Interacting Protein Pleckstrin homology (PH) domain
      TIGR02168
      Location:667 → 977
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      44953472..45073388
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006246424.5 → XP_006246486.1  myosin phosphatase Rho-interacting protein isoform X2

      See identical proteins and their annotated locations for XP_006246486.1

      UniProtKB/TrEMBL
      A0A8I5ZXY0, A0A8I6A006
      Conserved Domains (4) summary
      COG1196
      Location:932 → 1219
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd01236
      Location:16 → 151
      PH_RIP; Rho-Interacting Protein Pleckstrin homology (PH) domain
      cd13275
      Location:512 → 613
      PH_M-RIP; Myosin phosphatase-RhoA Interacting Protein Pleckstrin homology (PH) domain
      TIGR02168
      Location:771 → 1065
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type

    2. XM_063268288.1 → XP_063124358.1  myosin phosphatase Rho-interacting protein isoform X1

    3. XM_063268291.1 → XP_063124361.1  myosin phosphatase Rho-interacting protein isoform X6

    4. XM_063268292.1 → XP_063124362.1  myosin phosphatase Rho-interacting protein isoform X8

    5. XM_006246431.5 → XP_006246493.1  myosin phosphatase Rho-interacting protein isoform X11

      UniProtKB/Swiss-Prot
      Q4KM03, Q9ERE6
      UniProtKB/TrEMBL
      G3V9F3
      Related
      ENSRNOP00000045501.4, ENSRNOT00000040865.8
      Conserved Domains (6) summary
      cd01236
      Location:16 → 151
      PH_RIP; Rho-Interacting Protein Pleckstrin homology (PH) domain
      cd13275
      Location:512 → 613
      PH_M-RIP; Myosin phosphatase-RhoA Interacting Protein Pleckstrin homology (PH) domain
      pfam00169
      Location:512 → 600
      PH; PH domain
      pfam15619
      Location:801 → 1002
      Lebercilin; Ciliary protein causing Leber congenital amaurosis disease
      cl02488
      Location:860 → 1098
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      cl03951
      Location:761 → 879
      CDC37_N; Cdc37 N terminal kinase binding

    6. XM_063268295.1 → XP_063124365.1  myosin phosphatase Rho-interacting protein isoform X12

    7. XM_006246425.5 → XP_006246487.1  myosin phosphatase Rho-interacting protein isoform X4

      UniProtKB/TrEMBL
      A0A0G2JUR5, A0A8I6A006
      Conserved Domains (5) summary
      cd01236
      Location:16 → 151
      PH_RIP; Rho-Interacting Protein Pleckstrin homology (PH) domain
      cd13275
      Location:394 → 495
      PH_M-RIP; Myosin phosphatase-RhoA Interacting Protein Pleckstrin homology (PH) domain
      pfam00169
      Location:394 → 482
      PH; PH domain
      pfam01442
      Location:1948 → 2122
      Apolipoprotein; Apolipoprotein A1/A4/E domain
      pfam17045
      Location:820 → 1044
      CEP63; Centrosomal protein of 63 kDa

    8. XM_006246432.5 → XP_006246494.1  myosin phosphatase Rho-interacting protein isoform X14

      UniProtKB/Swiss-Prot
      Q4KM03, Q9ERE6
      Conserved Domains (5) summary
      cd01236
      Location:16 → 151
      PH_RIP; Rho-Interacting Protein Pleckstrin homology (PH) domain
      cd13275
      Location:394 → 495
      PH_M-RIP; Myosin phosphatase-RhoA Interacting Protein Pleckstrin homology (PH) domain
      pfam00169
      Location:394 → 482
      PH; PH domain
      cl02488
      Location:742 → 980
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      cl03951
      Location:643 → 761
      CDC37_N; Cdc37 N terminal kinase binding

    9. XM_063268298.1 → XP_063124368.1  myosin phosphatase Rho-interacting protein isoform X16

    10. XM_006246427.5 → XP_006246489.1  myosin phosphatase Rho-interacting protein isoform X7

      UniProtKB/TrEMBL
      A0A140TA95, A0A8I6A006
      Related
      ENSRNOP00000004357.7, ENSRNOT00000004357.9
      Conserved Domains (5) summary
      cd01236
      Location:16 → 151
      PH_RIP; Rho-Interacting Protein Pleckstrin homology (PH) domain
      cd13275
      Location:358 → 459
      PH_M-RIP; Myosin phosphatase-RhoA Interacting Protein Pleckstrin homology (PH) domain
      pfam00169
      Location:358 → 446
      PH; PH domain
      pfam01442
      Location:1912 → 2086
      Apolipoprotein; Apolipoprotein A1/A4/E domain
      pfam17045
      Location:784 → 1008
      CEP63; Centrosomal protein of 63 kDa

    11. XM_017596957.3 → XP_017452446.1  myosin phosphatase Rho-interacting protein isoform X18

      UniProtKB/Swiss-Prot
      Q4KM03, Q9ERE6

    12. XM_063268301.1 → XP_063124371.1  myosin phosphatase Rho-interacting protein isoform X20

    13. XM_063268297.1 → XP_063124367.1  myosin phosphatase Rho-interacting protein isoform X15

      UniProtKB/TrEMBL
      A6HF15
      Related
      ENSRNOP00000100472.1, ENSRNOT00000127867.1

    14. XM_063268300.1 → XP_063124370.1  myosin phosphatase Rho-interacting protein isoform X19

    15. XM_063268294.1 → XP_063124364.1  myosin phosphatase Rho-interacting protein isoform X10

    16. XM_063268289.1 → XP_063124359.1  myosin phosphatase Rho-interacting protein isoform X3

    17. XM_063268296.1 → XP_063124366.1  myosin phosphatase Rho-interacting protein isoform X13

    18. XM_063268290.1 → XP_063124360.1  myosin phosphatase Rho-interacting protein isoform X5

    19. XM_063268299.1 → XP_063124369.1  myosin phosphatase Rho-interacting protein isoform X17

    20. XM_063268293.1 → XP_063124363.1  myosin phosphatase Rho-interacting protein isoform X9

    21. XM_039085047.2 → XP_038940975.2  myosin phosphatase Rho-interacting protein isoform X9

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9ERE6.1 GenPept UniProtKB/Swiss-Prot:Q9ERE6

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