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    PLCE1 phospholipase C epsilon 1 [ Hylobates moloch (silvery gibbon) ]

    Gene ID: 116457306, updated on 18-Mar-2024

    Summary

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    Gene symbol
    PLCE1
    Gene description
    phospholipase C epsilon 1
    See related
    EnsemblRapid:ENSHMOG00010025918
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Hylobates moloch
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hylobatidae; Hylobates
    Orthologs
    human mouse all
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    Genomic context

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    See PLCE1 in Genome Data Viewer
    Location:
    chromosome: Un
    Exon count:
    35
    Annotation release Status Assembly Chr Location
    RS_2023_07 current HMol_V3 (GCF_009828535.3) Unplaced Scaffold NW_026652278.1 (39315030..39665527, complement)
    100 previous assembly HMol (GCF_009828535.1) Unplaced Scaffold NW_022454844.1 (39315030..39665527, complement)

    NW_026652278.1Genomic Context describing neighboring genes Neighboring gene helicase, lymphoid specific Neighboring gene TBC1 domain family member 12 Neighboring gene NOC3 like DNA replication regulator Neighboring gene uncharacterized LOC116457342 Neighboring gene U6 spliceosomal RNA Neighboring gene histone deacetylase 1-like Neighboring gene putative PIP5K1A and PSMD4-like protein Neighboring gene solute carrier family 35 member G1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    2. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables guanyl-nucleotide exchange factor activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables phosphatidylinositol phospholipase C activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in lipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in phosphatidylinositol-mediated signaling IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in small GTPase-mediated signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_009828535.3-RS_2023_07

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference HMol_V3

    Genomic

    1. NW_026652278.1 Reference HMol_V3

      Range
      39315030..39665527 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_032136433.1 → XP_031992324.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 isoform X2

      Related
      ENSHMOP00010031080.1, ENSHMOT00010039383.1
      Conserved Domains (6) summary
      cd00275
      Location:1873 → 1985
      C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
      cd08596
      Location:1392 → 1834
      PI-PLCc_epsilon; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-epsilon
      cd16203
      Location:1199 → 1379
      EFh_PI-PLCepsilon; EF-hand motif found in phosphoinositide phospholipase C epsilon 1 (PI-PLC-epsilon1)
      cd01780
      Location:2135 → 2237
      RA2_PLC-epsilon; Ras-associating (RA) domain 2 found in Phosphatidylinositide-specific phospholipase C (PLC)-epsilon
      cd17229
      Location:2008 → 2115
      RA1_PLC-epsilon; Ras-associating (RA) domain 1 found in Phosphatidylinositide-specific phospholipase C (PLC)-epsilon
      cl02485
      Location:532 → 825
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...

    2. XM_032136449.1 → XP_031992340.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 isoform X3

      Related
      ENSHMOP00010031073.1, ENSHMOT00010039374.1
      Conserved Domains (6) summary
      cd00275
      Location:1565 → 1677
      C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
      cd08596
      Location:1084 → 1526
      PI-PLCc_epsilon; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-epsilon
      cd16203
      Location:891 → 1071
      EFh_PI-PLCepsilon; EF-hand motif found in phosphoinositide phospholipase C epsilon 1 (PI-PLC-epsilon1)
      cd01780
      Location:1827 → 1929
      RA2_PLC-epsilon; Ras-associating (RA) domain 2 found in Phosphatidylinositide-specific phospholipase C (PLC)-epsilon
      cd17229
      Location:1700 → 1807
      RA1_PLC-epsilon; Ras-associating (RA) domain 1 found in Phosphatidylinositide-specific phospholipase C (PLC)-epsilon
      cl02485
      Location:224 → 517
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...

    3. XM_058436200.1 → XP_058292183.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 isoform X1

    4. XM_058436201.1 → XP_058292184.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 isoform X4

    Nucleotide Protein
    Heading Accession and Version

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