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    PHLDB1 pleckstrin homology like domain family B member 1 [ Rhinatrema bivittatum (two-lined caecilian) ]

    Gene ID: 115074637, updated on 17-Mar-2024

    Summary

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    Gene symbol
    PHLDB1
    Gene description
    pleckstrin homology like domain family B member 1
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Rhinatrema bivittatum
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Gymnophiona; Rhinatrematidae; Rhinatrema
    Orthologs
    human mouse all
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    Genomic context

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    See PHLDB1 in Genome Data Viewer
    Location:
    chromosome: 12
    Exon count:
    28
    Annotation release Status Assembly Chr Location
    100 current aRhiBiv1.1 (GCF_901001135.1) 12 NC_042626.1 (22063154..22167046, complement)

    Chromosome 12 - NC_042626.1Genomic Context describing neighboring genes Neighboring gene DEAD-box helicase 6 Neighboring gene trehalase Neighboring gene archain 1 Neighboring gene intraflagellar transport 46 Neighboring gene transmembrane protein 25

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_042626.1 Chromosome 12 Reference aRhiBiv1.1 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Multi-tissue transcriptomes of caecilian amphibians highlight incomplete knowledge of vertebrate gene families. Torres-Sánchez M, et al. DNA Res, 2019 Feb 1. PMID 30351380, Free PMC Article
    2. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables protein binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in regulation of microtubule cytoskeleton organization IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in basal cortex IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    pleckstrin homology-like domain family B member 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Rhinatrema bivittatum Annotation Release 100 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference aRhiBiv1.1 Primary Assembly

    Genomic

    1. NC_042626.1 Reference aRhiBiv1.1 Primary Assembly

      Range
      22063154..22167046 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_029574276.1 → XP_029430136.1  pleckstrin homology-like domain family B member 1 isoform X13

    2. XM_029574265.1 → XP_029430125.1  pleckstrin homology-like domain family B member 1 isoform X3

      Conserved Domains (6) summary
      PTZ00449
      Location:361 → 616
      PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
      COG1196
      Location:783 → 1012
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd00060
      Location:39 → 134
      FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
      cd14673
      Location:1427 → 1553
      PH_PHLDB1_2; Pleckstrin homology-like domain-containing family B member 2 pleckstrin homology (PH) domain
      pfam00769
      Location:1316 → 1391
      ERM; Ezrin/radixin/moesin family
      pfam17823
      Location:210 → 489
      DUF5585; Family of unknown function (DUF5585)

    3. XM_029574269.1 → XP_029430129.1  pleckstrin homology-like domain family B member 1 isoform X6

    4. XM_029574268.1 → XP_029430128.1  pleckstrin homology-like domain family B member 1 isoform X5

      Conserved Domains (6) summary
      PTZ00449
      Location:361 → 616
      PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
      COG1196
      Location:783 → 1012
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd00060
      Location:39 → 134
      FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
      cd14673
      Location:1427 → 1541
      PH_PHLDB1_2; Pleckstrin homology-like domain-containing family B member 2 pleckstrin homology (PH) domain
      pfam00769
      Location:1316 → 1391
      ERM; Ezrin/radixin/moesin family
      pfam17823
      Location:210 → 489
      DUF5585; Family of unknown function (DUF5585)

    5. XM_029574263.1 → XP_029430123.1  pleckstrin homology-like domain family B member 1 isoform X1

      Conserved Domains (6) summary
      PTZ00449
      Location:361 → 616
      PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
      COG1196
      Location:783 → 1012
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd00060
      Location:39 → 134
      FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
      cd14673
      Location:1427 → 1554
      PH_PHLDB1_2; Pleckstrin homology-like domain-containing family B member 2 pleckstrin homology (PH) domain
      pfam00769
      Location:1316 → 1391
      ERM; Ezrin/radixin/moesin family
      pfam17823
      Location:210 → 489
      DUF5585; Family of unknown function (DUF5585)

    6. XM_029574270.1 → XP_029430130.1  pleckstrin homology-like domain family B member 1 isoform X7

    7. XM_029574266.1 → XP_029430126.1  pleckstrin homology-like domain family B member 1 isoform X4

      Conserved Domains (6) summary
      PTZ00449
      Location:361 → 616
      PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
      COG1196
      Location:783 → 1012
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd00060
      Location:39 → 134
      FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
      cd14673
      Location:1416 → 1543
      PH_PHLDB1_2; Pleckstrin homology-like domain-containing family B member 2 pleckstrin homology (PH) domain
      pfam02463
      Location:744 → 1375
      SMC_N; RecF/RecN/SMC N terminal domain
      pfam17823
      Location:210 → 489
      DUF5585; Family of unknown function (DUF5585)

    8. XM_029574273.1 → XP_029430133.1  pleckstrin homology-like domain family B member 1 isoform X10

    9. XM_029574283.1 → XP_029430143.1  pleckstrin homology-like domain family B member 1 isoform X19

    10. XM_029574264.1 → XP_029430124.1  pleckstrin homology-like domain family B member 1 isoform X2

    11. XM_029574271.1 → XP_029430131.1  pleckstrin homology-like domain family B member 1 isoform X8

    12. XM_029574272.1 → XP_029430132.1  pleckstrin homology-like domain family B member 1 isoform X9

      Conserved Domains (7) summary
      PTZ00449
      Location:361 → 616
      PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
      COG1196
      Location:782 → 965
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd00060
      Location:39 → 134
      FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
      cd14673
      Location:1384 → 1511
      PH_PHLDB1_2; Pleckstrin homology-like domain-containing family B member 2 pleckstrin homology (PH) domain
      TIGR02168
      Location:619 → 894
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam00769
      Location:1273 → 1348
      ERM; Ezrin/radixin/moesin family
      pfam17823
      Location:210 → 489
      DUF5585; Family of unknown function (DUF5585)

    13. XM_029574274.1 → XP_029430134.1  pleckstrin homology-like domain family B member 1 isoform X11

    14. XM_029574275.1 → XP_029430135.1  pleckstrin homology-like domain family B member 1 isoform X12

    15. XM_029574277.1 → XP_029430137.1  pleckstrin homology-like domain family B member 1 isoform X14

      Conserved Domains (7) summary
      PTZ00449
      Location:361 → 616
      PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
      COG0419
      Location:787 → 1316
      SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
      COG1196
      Location:781 → 964
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd00060
      Location:39 → 134
      FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
      cd14673
      Location:1330 → 1434
      PH_PHLDB1_2; Pleckstrin homology-like domain-containing family B member 2 pleckstrin homology (PH) domain
      TIGR02169
      Location:631 → 927
      SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type
      pfam17823
      Location:210 → 489
      DUF5585; Family of unknown function (DUF5585)

    16. XM_029574280.1 → XP_029430140.1  pleckstrin homology-like domain family B member 1 isoform X16

      Conserved Domains (7) summary
      PTZ00449
      Location:361 → 616
      PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
      COG0419
      Location:787 → 1233
      SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
      COG1196
      Location:781 → 964
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd00060
      Location:39 → 134
      FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
      cd14673
      Location:1280 → 1384
      PH_PHLDB1_2; Pleckstrin homology-like domain-containing family B member 2 pleckstrin homology (PH) domain
      TIGR02168
      Location:620 → 893
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam17823
      Location:210 → 489
      DUF5585; Family of unknown function (DUF5585)

    17. XM_029574279.1 → XP_029430139.1  pleckstrin homology-like domain family B member 1 isoform X15

      Conserved Domains (5) summary
      PTZ00449
      Location:241 → 496
      PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
      COG1196
      Location:663 → 892
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd14673
      Location:1307 → 1434
      PH_PHLDB1_2; Pleckstrin homology-like domain-containing family B member 2 pleckstrin homology (PH) domain
      pfam00769
      Location:1196 → 1271
      ERM; Ezrin/radixin/moesin family
      pfam17823
      Location:90 → 369
      DUF5585; Family of unknown function (DUF5585)

    18. XM_029574281.1 → XP_029430141.1  pleckstrin homology-like domain family B member 1 isoform X17

    19. XM_029574282.1 → XP_029430142.1  pleckstrin homology-like domain family B member 1 isoform X18

      Conserved Domains (5) summary
      PTZ00449
      Location:361 → 616
      PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
      COG1196
      Location:783 → 1012
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd00060
      Location:39 → 134
      FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
      pfam00769
      Location:1316 → 1390
      ERM; Ezrin/radixin/moesin family
      pfam17823
      Location:210 → 489
      DUF5585; Family of unknown function (DUF5585)
    Nucleotide Protein
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