Adam19 ADAM metallopeptidase domain 19 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Adam19provided by MGI
Official Full Name: ADAM metallopeptidase domain 19provided by MGI
Primary source: MGI:MGI:105377
See related: Ensembl:ENSMUSG00000011256 AllianceGenome:MGI:105377
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: MTLNB; Mltnb; MADDAM
Summary: This gene encodes a cell surface glycoprotein and member of the ADAM (a disintegrin and metalloproteinase) family of endopeptidases. The encoded protein may play a role in the ectodomain shedding of neuregulin proteins. Homozygous knockout mice for this gene exhibit heart development defects and perinatal lethality. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that undergoes proteolytic processing to generate a mature protein product. [provided by RefSeq, Aug 2015]
Expression: Ubiquitous expression in lung adult (RPKM 11.0), limb E14.5 (RPKM 10.3) and 26 other tissues See more
Orthologs: human all
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Genomic context

Location:: 11 B1.1; 11 27.54 cM

Exon count:: 26

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	11	NC_000077.7 (45945329..46038174)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	11	NC_000077.6 (46054502..46147347)

Chromosome 11 - NC_000077.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Adam19 Deficiency Impacts Pulmonary Function: Human GWAS Follow-up in a Mouse Knockout Model.
Title: Adam19 Deficiency Impacts Pulmonary Function: Human GWAS Follow-up in a Mouse Knockout Model.
TGF-beta stimulation of renal cells results in a significant up-regulation of Adams 10, 17, 12, and 19
Title: Canonical transforming growth factor-β signaling regulates disintegrin metalloprotease expression in experimental renal fibrosis via miR-29.
Thus, we found that electrical stimulation accelerated NMJ formation, possibly through activation of ADAM19/neuregulin/ErbB signaling in NG108-15 cells.
Title: Electrical stimulation accelerates neuromuscular junction formation through ADAM19/neuregulin/ErbB signaling in vitro.
It plays multiple roles in the regulation of signal transduction between neuronal cells. (review)
Title: [Multiple roles of Meltrinbeta/ADAM19 on the regulation of signal transduction between neuronal cells].
meltrin-beta functions as a modulator of juxtacrine signaling from axons that activate the Akt pathway and the Krox-20 expression, which is the prerequisite for Schwann cell differentiation
Title: Roles of meltrin-beta/ADAM19 in progression of Schwann cell differentiation and myelination during sciatic nerve regeneration.
This study identifies a novel sheddase, ADAM17, for Kitl1 and Kitl2, and demonstrates that ADAM19 can reduce ADAM17-dependent phorbol-ester-stimulated Kitl1 ectodomain shedding.
Title: Different ADAMs have distinct influences on Kit ligand processing: phorbol-ester-stimulated ectodomain shedding of Kitl1 by ADAM17 is reduced by ADAM19.
Meltrin beta expressed in cardiac neural crest cells is required for ventricular septum formation of the heart.
Title: Meltrin beta expressed in cardiac neural crest cells is required for ventricular septum formation of the heart.
Meltrin beta-mini is a new isoform that induces neuron outgrowth in neuronal cells
Title: Meltrin beta mini, a new ADAM19 isoform lacking metalloprotease and disintegrin domains, induces morphological changes in neuronal cells.
evaluation of its catalytic activity; potential role in shedding TRANCE in cells where both molecules are highly expressed, such as in osteoblasts
Title: Catalytic properties of ADAM19.
participates in the development of the endocardial cushion
Title: Essential roles of Meltrin beta (ADAM19) in heart development.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Gene trapped (2) 1 citation
Targeted (4) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH125519 (e-PCR)
- UniSTS:162336

AI431060 (e-PCR)
- UniSTS:160087

Adam19 (e-PCR), detects polymorphism
- UniSTS:547503

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables SH3 domain binding	IMP Inferred from Mutant Phenotype more info	PubMed
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables metalloendopeptidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables metalloendopeptidase activity	ISO Inferred from Sequence Orthology more info
enables metalloendopeptidase activity	ISS Inferred from Sequence or Structural Similarity more info
enables metalloendopeptidase activity involved in amyloid precursor protein catabolic process	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in amyloid precursor protein catabolic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within heart development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in membrane protein ectodomain proteolysis	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within membrane protein ectodomain proteolysis	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within membrane protein ectodomain proteolysis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in placenta development	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of cell-cell adhesion mediated by cadherin	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell-cell adhesion mediated by cadherin	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of gene expression	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein processing	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in Golgi apparatus	IDA Inferred from Direct Assay more info	PubMed
located_in collagen-containing extracellular matrix	HDA more info	PubMed
NOT located_in external side of plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: disintegrin and metalloproteinase domain-containing protein 19

Names: MDC beta; Mel beta; a disintegrin and metallopeptidase domain 19 (meltrin beta); a disintegrin and metalloproteinase domain 19 (meltrin beta); adamalysin 19

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001291890.1 → NP_001278819.1 disintegrin and metalloproteinase domain-containing protein 19 isoform 2

See identical proteins and their annotated locations for NP_001278819.1

Status: REVIEWED

Description

Transcript Variant: This variant (2) differs in the 5' UTR and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (2) has a distinct N-terminus and is shorter than isoform 1.

Source sequence(s)

AK147549, BC093480, CJ248266

UniProtKB/TrEMBL

Q3UH67

Conserved Domains (5) summary

smart00050
Location:420 → 480

DISIN; Homologues of snake disintegrins

smart00608
Location:482 → 630

ACR; ADAM Cysteine-Rich Domain

cd04269
Location:191 → 387

ZnMc_adamalysin_II_like; Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom zinc endopeptidase. This subfamily contains other snake venom metalloproteinases, as well as membrane-anchored metalloproteases belonging to the ADAM family. ...

pfam01421
Location:191 → 389

Reprolysin; Reprolysin (M12B) family zinc metalloprotease

pfam01562
Location:35 → 142

Pep_M12B_propep; Reprolysin family propeptide
NM_001291891.1 → NP_001278820.1 disintegrin and metalloproteinase domain-containing protein 19 isoform 3

Status: REVIEWED

Description

Transcript Variant: This variant (3) uses an alternate internal splice site, compared to variant 1. This variant represents translation initiation at a downstream AUG compared to variant 1; the 5'-most initiation codon, as used in variant 1, is associated with a truncated ORF that would render the transcript a candidate for nonsense-mediated decay (NMD). Leaky scanning may allow translation initiation at the downstream AUG to encode an isoform (3) that has a shorter N-terminus, compared to isoform 1.

Source sequence(s)

AL663031, BC093480, CJ248266

Conserved Domains (3) summary

smart00050
Location:123 → 183

DISIN; Homologues of snake disintegrins

smart00608
Location:185 → 333

ACR; ADAM Cysteine-Rich Domain

cl00064
Location:3 → 90

ZnMc; Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which ...
NM_001311209.1 → NP_001298138.1 disintegrin and metalloproteinase domain-containing protein 19 isoform 4

Status: REVIEWED

Description

Transcript Variant: This variant (4, also known as meltrin beta mini) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start site compared to variant 1. The encoded isoform (4) has a shorter N-terminus and lacks the prodomain, metalloprotease and disintegrin domains, compared to isoform 1.

Source sequence(s)

AK147217, AL663031, CJ248266

UniProtKB/TrEMBL

Q80UF6

Conserved Domains (1) summary

smart00608
Location:1 → 149

ACR; ADAM Cysteine-Rich Domain
NM_009616.4 → NP_033746.1 disintegrin and metalloproteinase domain-containing protein 19 isoform 1 preproprotein

See identical proteins and their annotated locations for NP_033746.1

Status: REVIEWED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).

Source sequence(s)

AK147217, AL663031, CJ111383, CJ248266

Consensus CDS

CCDS24571.1

UniProtKB/Swiss-Prot

O35674

UniProtKB/TrEMBL

Q3UHT3

Related

ENSMUSP00000011400.8, ENSMUST00000011400.8

Conserved Domains (5) summary

smart00050
Location:440 → 500

DISIN; Homologues of snake disintegrins

smart00608
Location:502 → 650

ACR; ADAM Cysteine-Rich Domain

cd04269
Location:211 → 407

ZnMc_adamalysin_II_like; Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom zinc endopeptidase. This subfamily contains other snake venom metalloproteinases, as well as membrane-anchored metalloproteases belonging to the ADAM family. ...

pfam01421
Location:211 → 409

Reprolysin; Reprolysin (M12B) family zinc metalloprotease

pfam01562
Location:55 → 162

Pep_M12B_propep; Reprolysin family propeptide

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000077.7 Reference GRCm39 C57BL/6J

Range

45945329..46038174

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_030245480.2 → XP_030101340.1 disintegrin and metalloproteinase domain-containing protein 19 isoform X2

Conserved Domains (3) summary

smart00050
Location:239 → 299

DISIN; Homologues of snake disintegrins

smart00608
Location:301 → 449

ACR; ADAM Cysteine-Rich Domain

pfam01421
Location:10 → 208

Reprolysin; Reprolysin (M12B) family zinc metalloprotease
XM_036156242.1 → XP_036012135.1 disintegrin and metalloproteinase domain-containing protein 19 isoform X1

Conserved Domains (4) summary

smart00050
Location:417 → 477

DISIN; Homologues of snake disintegrins

smart00608
Location:479 → 627

ACR; ADAM Cysteine-Rich Domain

pfam01421
Location:188 → 386

Reprolysin; Reprolysin (M12B) family zinc metalloprotease

pfam01562
Location:62 → 140

Pep_M12B_propep; Reprolysin family propeptide