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    KMT2D lysine methyltransferase 2D [ Monodon monoceros (narwhal) ]

    Gene ID: 114885088, updated on 15-Mar-2024

    Summary

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    Gene symbol
    KMT2D
    Gene description
    lysine methyltransferase 2D
    See related
    Ensembl:ENSMMNG00015021547
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Monodon monoceros
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Odontoceti; Monodontidae; Monodon
    Orthologs
    human mouse all
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    Genomic context

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    See KMT2D in Genome Data Viewer
    Location:
    chromosome: Un
    Exon count:
    55
    Annotation release Status Assembly Chr Location
    100 current NGI_Narwhal_1 (GCF_005190385.1) Unplaced Scaffold NW_021703783.1 (37375664..37412948, complement)

    NW_021703783.1Genomic Context describing neighboring genes Neighboring gene dendrin Neighboring gene protein kinase AMP-activated non-catalytic subunit gamma 1 Neighboring gene RHEB like 1 Neighboring gene desert hedgehog signaling molecule

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NW_021703783 Unplaced Scaffold Reference NGI_Narwhal_1

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    2. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables histone H3K4 methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables histone binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables transcription coactivator activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in positive regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of MLL3/4 complex IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    histone-lysine N-methyltransferase 2D

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Monodon monoceros Annotation Release 100 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference NGI_Narwhal_1

    Genomic

    1. NW_021703783.1 Reference NGI_Narwhal_1

      Range
      37375664..37412948 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_029204432.1 → XP_029060265.1  histone-lysine N-methyltransferase 2D isoform X6

      UniProtKB/TrEMBL
      A0A8C6CDU4
      Conserved Domains (14) summary
      smart00398
      Location:1929 → 1980
      HMG; high mobility group
      smart00542
      Location:5103 → 5190
      FYRC; FY-rich domain, C-terminal region
      smart00317
      Location:5260 → 5382
      SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain
      smart00508
      Location:5384 → 5400
      PostSET; Cysteine-rich motif following a subset of SET domains
      PHA03247
      Location:548 → 1089
      PHA03247; large tegument protein UL36; Provisional
      cd15509
      Location:166 → 211
      PHD1_KMT2C_like; PHD finger 1 found in Histone-lysine N-methyltransferase 2C (KMT2C) and 2D (KMT2D)
      cd15513
      Location:1322 → 1368
      PHD5_KMT2C_like; PHD finger 5 found in Histone-lysine N-methyltransferase 2C (KMT2C) and PHD finger 4 found in KMT2D
      cd15595
      Location:213 → 258
      PHD2_KMT2D; PHD finger 2 found in Histone-lysine N-methyltransferase 2D (KMT2D)
      cd15597
      Location:1271 → 1321
      PHD3_KMT2D; PHD finger 3 found in Histone-lysine N-methyltransferase 2D (KMT2D)
      cd15601
      Location:1399 → 1449
      PHD5_KMT2D; PHD finger 5 found in Histone-lysine N-methyltransferase 2D (KMT2D)
      cd15695
      Location:72 → 155
      ePHD1_KMT2D; Extended PHD finger 1 found in histone-lysine N-methyltransferase 2D (KMT2D)
      cd15698
      Location:4895 → 5001
      ePHD2_KMT2D; Extended PHD finger 2 found in histone-lysine N-methyltransferase 2D (KMT2D)
      pfam09606
      Location:3858 → 4212
      Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
      pfam05964
      Location:5044 → 5095
      FYRN; F/Y-rich N-terminus

    2. XM_029204428.1 → XP_029060261.1  histone-lysine N-methyltransferase 2D isoform X2

      UniProtKB/TrEMBL
      A0A8C6CDU4
      Conserved Domains (14) summary
      smart00398
      Location:1990 → 2041
      HMG; high mobility group
      smart00542
      Location:5164 → 5251
      FYRC; FY-rich domain, C-terminal region
      smart00317
      Location:5321 → 5443
      SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain
      smart00508
      Location:5445 → 5461
      PostSET; Cysteine-rich motif following a subset of SET domains
      PHA03247
      Location:610 → 1151
      PHA03247; large tegument protein UL36; Provisional
      cd15509
      Location:228 → 273
      PHD1_KMT2C_like; PHD finger 1 found in Histone-lysine N-methyltransferase 2C (KMT2C) and 2D (KMT2D)
      cd15513
      Location:1383 → 1429
      PHD5_KMT2C_like; PHD finger 5 found in Histone-lysine N-methyltransferase 2C (KMT2C) and PHD finger 4 found in KMT2D
      cd15597
      Location:1332 → 1382
      PHD3_KMT2D; PHD finger 3 found in Histone-lysine N-methyltransferase 2D (KMT2D)
      cd15601
      Location:1460 → 1510
      PHD5_KMT2D; PHD finger 5 found in Histone-lysine N-methyltransferase 2D (KMT2D)
      cd15695
      Location:134 → 217
      ePHD1_KMT2D; Extended PHD finger 1 found in histone-lysine N-methyltransferase 2D (KMT2D)
      cd15698
      Location:4956 → 5062
      ePHD2_KMT2D; Extended PHD finger 2 found in histone-lysine N-methyltransferase 2D (KMT2D)
      pfam09606
      Location:3919 → 4273
      Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
      pfam05964
      Location:5105 → 5156
      FYRN; F/Y-rich N-terminus
      cl22851
      Location:275 → 320
      PHD_SF; PHD finger superfamily

    3. XM_029204429.1 → XP_029060262.1  histone-lysine N-methyltransferase 2D isoform X3

      UniProtKB/TrEMBL
      A0A8C6CDU4
      Conserved Domains (14) summary
      smart00398
      Location:1988 → 2039
      HMG; high mobility group
      smart00542
      Location:5162 → 5249
      FYRC; FY-rich domain, C-terminal region
      smart00317
      Location:5319 → 5441
      SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain
      smart00508
      Location:5443 → 5459
      PostSET; Cysteine-rich motif following a subset of SET domains
      PHA03247
      Location:610 → 1151
      PHA03247; large tegument protein UL36; Provisional
      cd15509
      Location:228 → 273
      PHD1_KMT2C_like; PHD finger 1 found in Histone-lysine N-methyltransferase 2C (KMT2C) and 2D (KMT2D)
      cd15513
      Location:1384 → 1430
      PHD5_KMT2C_like; PHD finger 5 found in Histone-lysine N-methyltransferase 2C (KMT2C) and PHD finger 4 found in KMT2D
      cd15597
      Location:1333 → 1383
      PHD3_KMT2D; PHD finger 3 found in Histone-lysine N-methyltransferase 2D (KMT2D)
      cd15601
      Location:1461 → 1511
      PHD5_KMT2D; PHD finger 5 found in Histone-lysine N-methyltransferase 2D (KMT2D)
      cd15695
      Location:134 → 217
      ePHD1_KMT2D; Extended PHD finger 1 found in histone-lysine N-methyltransferase 2D (KMT2D)
      cd15698
      Location:4954 → 5060
      ePHD2_KMT2D; Extended PHD finger 2 found in histone-lysine N-methyltransferase 2D (KMT2D)
      pfam09606
      Location:3917 → 4271
      Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
      pfam05964
      Location:5103 → 5154
      FYRN; F/Y-rich N-terminus
      cl22851
      Location:275 → 320
      PHD_SF; PHD finger superfamily

    4. XM_029204427.1 → XP_029060260.1  histone-lysine N-methyltransferase 2D isoform X1

      UniProtKB/TrEMBL
      A0A8C6CDU4
      Conserved Domains (14) summary
      smart00398
      Location:1991 → 2042
      HMG; high mobility group
      smart00542
      Location:5165 → 5252
      FYRC; FY-rich domain, C-terminal region
      smart00317
      Location:5322 → 5444
      SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain
      smart00508
      Location:5446 → 5462
      PostSET; Cysteine-rich motif following a subset of SET domains
      PHA03247
      Location:610 → 1151
      PHA03247; large tegument protein UL36; Provisional
      cd15509
      Location:228 → 273
      PHD1_KMT2C_like; PHD finger 1 found in Histone-lysine N-methyltransferase 2C (KMT2C) and 2D (KMT2D)
      cd15513
      Location:1384 → 1430
      PHD5_KMT2C_like; PHD finger 5 found in Histone-lysine N-methyltransferase 2C (KMT2C) and PHD finger 4 found in KMT2D
      cd15595
      Location:275 → 320
      PHD2_KMT2D; PHD finger 2 found in Histone-lysine N-methyltransferase 2D (KMT2D)
      cd15597
      Location:1333 → 1383
      PHD3_KMT2D; PHD finger 3 found in Histone-lysine N-methyltransferase 2D (KMT2D)
      cd15601
      Location:1461 → 1511
      PHD5_KMT2D; PHD finger 5 found in Histone-lysine N-methyltransferase 2D (KMT2D)
      cd15695
      Location:134 → 217
      ePHD1_KMT2D; Extended PHD finger 1 found in histone-lysine N-methyltransferase 2D (KMT2D)
      cd15698
      Location:4957 → 5063
      ePHD2_KMT2D; Extended PHD finger 2 found in histone-lysine N-methyltransferase 2D (KMT2D)
      pfam09606
      Location:3920 → 4274
      Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
      pfam05964
      Location:5106 → 5157
      FYRN; F/Y-rich N-terminus

    5. XM_029204430.1 → XP_029060263.1  histone-lysine N-methyltransferase 2D isoform X4

      UniProtKB/TrEMBL
      A0A8C6CDU4
      Conserved Domains (14) summary
      smart00398
      Location:1979 → 2030
      HMG; high mobility group
      smart00542
      Location:5153 → 5240
      FYRC; FY-rich domain, C-terminal region
      smart00317
      Location:5310 → 5432
      SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain
      smart00508
      Location:5434 → 5450
      PostSET; Cysteine-rich motif following a subset of SET domains
      PHA03247
      Location:610 → 1151
      PHA03247; large tegument protein UL36; Provisional
      cd15509
      Location:228 → 273
      PHD1_KMT2C_like; PHD finger 1 found in Histone-lysine N-methyltransferase 2C (KMT2C) and 2D (KMT2D)
      cd15513
      Location:1384 → 1430
      PHD5_KMT2C_like; PHD finger 5 found in Histone-lysine N-methyltransferase 2C (KMT2C) and PHD finger 4 found in KMT2D
      cd15597
      Location:1333 → 1383
      PHD3_KMT2D; PHD finger 3 found in Histone-lysine N-methyltransferase 2D (KMT2D)
      cd15601
      Location:1461 → 1511
      PHD5_KMT2D; PHD finger 5 found in Histone-lysine N-methyltransferase 2D (KMT2D)
      cd15695
      Location:134 → 217
      ePHD1_KMT2D; Extended PHD finger 1 found in histone-lysine N-methyltransferase 2D (KMT2D)
      cd15698
      Location:4945 → 5051
      ePHD2_KMT2D; Extended PHD finger 2 found in histone-lysine N-methyltransferase 2D (KMT2D)
      pfam09606
      Location:3908 → 4262
      Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
      pfam05964
      Location:5094 → 5145
      FYRN; F/Y-rich N-terminus
      cl22851
      Location:275 → 320
      PHD_SF; PHD finger superfamily

    6. XM_029204431.1 → XP_029060264.1  histone-lysine N-methyltransferase 2D isoform X5

      UniProtKB/TrEMBL
      A0A8C6CDU4
      Related
      ENSMMNP00015029582.1, ENSMMNT00015032495.1
      Conserved Domains (14) summary
      smart00398
      Location:1976 → 2027
      HMG; high mobility group
      smart00542
      Location:5150 → 5237
      FYRC; FY-rich domain, C-terminal region
      smart00317
      Location:5307 → 5429
      SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain
      smart00508
      Location:5431 → 5447
      PostSET; Cysteine-rich motif following a subset of SET domains
      PHA03247
      Location:610 → 1151
      PHA03247; large tegument protein UL36; Provisional
      cd15509
      Location:228 → 273
      PHD1_KMT2C_like; PHD finger 1 found in Histone-lysine N-methyltransferase 2C (KMT2C) and 2D (KMT2D)
      cd15513
      Location:1384 → 1430
      PHD5_KMT2C_like; PHD finger 5 found in Histone-lysine N-methyltransferase 2C (KMT2C) and PHD finger 4 found in KMT2D
      cd15597
      Location:1333 → 1383
      PHD3_KMT2D; PHD finger 3 found in Histone-lysine N-methyltransferase 2D (KMT2D)
      cd15601
      Location:1461 → 1511
      PHD5_KMT2D; PHD finger 5 found in Histone-lysine N-methyltransferase 2D (KMT2D)
      cd15695
      Location:134 → 217
      ePHD1_KMT2D; Extended PHD finger 1 found in histone-lysine N-methyltransferase 2D (KMT2D)
      cd15698
      Location:4942 → 5048
      ePHD2_KMT2D; Extended PHD finger 2 found in histone-lysine N-methyltransferase 2D (KMT2D)
      pfam09606
      Location:3905 → 4259
      Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
      pfam05964
      Location:5091 → 5142
      FYRN; F/Y-rich N-terminus
      cl22851
      Location:275 → 320
      PHD_SF; PHD finger superfamily
    Nucleotide Protein
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