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    neurod2 neuronal differentiation 2 [ Danio rerio (zebrafish) ]

    Gene ID: 114435, updated on 9-Dec-2024

    Summary

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    Official Symbol
    neurod2provided by ZNC
    Official Full Name
    neuronal differentiation 2provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-010608-3
    See related
    Ensembl:ENSDARG00000016854 AllianceGenome:ZFIN:ZDB-GENE-010608-3
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    ndr2; zNdr2; fj49a11; wu:fj49a11
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and E-box binding activity. Predicted to be involved in axon development; positive regulation of transcription by RNA polymerase II; and sensory organ development. Predicted to act upstream of or within cell differentiation; nervous system development; and regulation of DNA-templated transcription. Predicted to be active in nucleus. Is expressed in granule cell. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 72. Orthologous to human NEUROD2 (neuronal differentiation 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See neurod2 in Genome Data Viewer
    Location:
    chromosome: 12
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 12 NC_007123.7 (14916307..14924786, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 12 NC_007123.6 (14881787..14884600, complement)

    Chromosome 12 - NC_007123.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC103911903 Neighboring gene uncharacterized LOC137496801 Neighboring gene uncharacterized LOC137496802 Neighboring gene protein kinase, membrane associated tyrosine/threonine 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. An embryonic 100μg/L lead exposure results in sex-specific expression changes in genes associated with the neurological system in female or cancer in male adult zebrafish brains. Lee J, et al. Neurotoxicol Teratol, 2018 Jan-Feb. PMID 29074346
    2. Neurogenetic asymmetries in the catshark developing habenulae: mechanistic and evolutionary implications. Lagadec R, et al. Sci Rep, 2018 Mar 15. PMID 29545638, Free PMC Article
    3. Multiplicity of Buc copies in Atlantic salmon contrasts with loss of the germ cell determinant in primates, rodents and axolotl. Škugor A, et al. BMC Evol Biol, 2016 Oct 26. PMID 27784263, Free PMC Article
    4. No evidence for AID/MBD4-coupled DNA demethylation in zebrafish embryos. Shimoda N, et al. PLoS One, 2014. PMID 25536520, Free PMC Article
    5. Identification of an evolutionarily conserved domain in Neurod1 favouring enteroendocrine versus goblet cell fate. Reuter AS, et al. PLoS Genet, 2022 Mar. PMID 35286299, Free PMC Article

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables E-box binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein dimerization activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in axon development IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within cell differentiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within nervous system development IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in sensory organ development IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    neurogenic differentiation factor 2
    Names
    NDF2
    neurogenic differentiation 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_131082.1 → NP_571157.1  neurogenic differentiation factor 2

      See identical proteins and their annotated locations for NP_571157.1

      Status: PROVISIONAL

      Source sequence(s)
      AF115774
      UniProtKB/Swiss-Prot
      Q9W6C8
      Related
      ENSDARP00000023642.6, ENSDART00000002078.9
      Conserved Domains (2) summary
      cd00083
      Location:105 → 164
      HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...
      pfam12533
      Location:166 → 285
      Neuro_bHLH; Neuronal helix-loop-helix transcription factor

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007123.7 Reference GRCz11 Primary Assembly

      Range
      14916307..14924786 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_068224486.1 → XP_068080587.1  neurogenic differentiation factor 2 isoform X2

    2. XM_068224485.1 → XP_068080586.1  neurogenic differentiation factor 2 isoform X1

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9W6C8.1 GenPept UniProtKB/Swiss-Prot:Q9W6C8

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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