Lyve1 lymphatic vessel endothelial hyaluronan receptor 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Lyve1provided by MGI
Official Full Name: lymphatic vessel endothelial hyaluronan receptor 1provided by MGI
Primary source: MGI:MGI:2136348
See related: Ensembl:ENSMUSG00000030787 AllianceGenome:MGI:2136348
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Xlkd1; Lyve-1; Crsbp-1; 1200012G08Rik
Summary: Enables cargo receptor activity; hyaluronic acid binding activity; and transmembrane signaling receptor activity. Involved in hyaluronan catabolic process and receptor-mediated endocytosis. Acts upstream of or within glycosaminoglycan catabolic process. Located in plasma membrane. Is expressed in several structures, including alimentary system; cardiovascular system; hemolymphoid system; meninges; and metanephros. Orthologous to human LYVE1 (lymphatic vessel endothelial hyaluronan receptor 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Broad expression in lung adult (RPKM 22.3), liver E18 (RPKM 15.1) and 15 other tissues See more
Orthologs: human all
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Genomic context

Location:: 7 E3; 7 57.89 cM

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	7	NC_000073.7 (110449814..110462160, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	7	NC_000073.6 (110850607..110862953, complement)

Chromosome 7 - NC_000073.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

hsa_circ_0129047 Upregulates LYVE1 to Inhibit Hepatocellular Carcinoma Progression by Sponging miR-492.
Title: hsa_circ_0129047 Upregulates LYVE1 to Inhibit Hepatocellular Carcinoma Progression by Sponging miR-492.
Three tissue resident macrophage subsets coexist across organs with conserved origins and life cycles.
Title: Three tissue resident macrophage subsets coexist across organs with conserved origins and life cycles.
Retinal VEGF-A Overexpression Is Not Sufficient to Induce Lymphangiogenesis Regardless of VEGF-C Upregulation and Lyve1+ Macrophage Infiltration.
Title: Retinal VEGF-A Overexpression Is Not Sufficient to Induce Lymphangiogenesis Regardless of VEGF-C Upregulation and Lyve1+ Macrophage Infiltration.
Adventitial recruitment of Lyve-1- macrophages drives aortic aneurysm in an angiotensin-2-based murine model.
Title: Adventitial recruitment of Lyve-1- macrophages drives aortic aneurysm in an angiotensin-2-based murine model.
novel role of HIF-1alpha/PROX-1/LYVE-1 axis on tissue regeneration after renal ischaemia/reperfusion
Title: A novel role of HIF-1α/PROX-1/LYVE-1 axis on tissue regeneration after renal ischaemia/reperfusion in mice.
PROX1 and LYVE1 may participate in this process and serve as biomarkers for identification of newly formed liver sinusoidal endothelial cells.
Title: LYVE1 and PROX1 in the reconstruction of hepatic sinusoids after partial hepatectomy in mice.
This study has unveiled a hitherto unknown homeostatic contribution of arterial LYVE-1(+) macrophages through the control of collagen production by smooth muscle cells and has identified a function of LYVE-1 in leukocytes.
Title: Hyaluronan Receptor LYVE-1-Expressing Macrophages Maintain Arterial Tone through Hyaluronan-Mediated Regulation of Smooth Muscle Cell Collagen.
Study in metastatic MDA-MB-231 xenograft models shows that LYVE-1 is involved in primary tumor formation and metastasis, and it may be a promising molecular target for cancer therapy.
Title: Inhibition of tumor formation and metastasis by a monoclonal antibody against lymphatic vessel endothelial hyaluronan receptor 1.
lymphatic vessel endothelial hyaluronan receptor-1 (LYVE1) is identified as a marker of yolk sac (YS) endothelium and definitive hematopoietic stem and progenitor cells.
Title: LYVE1 Marks the Divergence of Yolk Sac Definitive Hemogenic Endothelium from the Primitive Erythroid Lineage.
Dendritic cells (DCs) docked to the basolateral surface of lymphatic vessels and transited to the lumen through hyaluronan-mediated interactions with the lymph-specific endothelial receptor LYVE-1. Targeted deletion of the gene Lyve1, antibody blockade or depletion of the DC hyaluronan coat not only delayed lymphatic trafficking of dermal DCs but also blunted their capacity to prime CD8(+) T cell responses in LNs.
Title: Dendritic cells enter lymph vessels by hyaluronan-mediated docking to the endothelial receptor LYVE-1.

Submit: New GeneRIF Correction See all GeneRIFs (39)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (7) 1 citation
Targeted (3) 1 citation

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables cargo receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables cargo receptor activity	ISO Inferred from Sequence Orthology more info	PubMed
enables hyaluronic acid binding	IBA Inferred from Biological aspect of Ancestor more info
enables hyaluronic acid binding	IDA Inferred from Direct Assay more info	PubMed
enables hyaluronic acid binding	ISO Inferred from Sequence Orthology more info
enables transmembrane signaling receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables transmembrane signaling receptor activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in cell adhesion	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within glycosaminoglycan catabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in hyaluronan catabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of cellular extravasation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of cellular extravasation	ISO Inferred from Sequence Orthology more info
involved_in receptor-mediated endocytosis	IDA Inferred from Direct Assay more info	PubMed
involved_in receptor-mediated endocytosis	ISO Inferred from Sequence Orthology more info	PubMed

Component	Evidence Code	Pubs
located_in cell periphery	IDA Inferred from Direct Assay more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: lymphatic vessel endothelial hyaluronic acid receptor 1

Names: cell surface retention sequence binding protein-1; extra cellular link domain-containing 1; extracellular link domain-containing protein 1; lymphatic vessel endothelial HA receptor-1; lymphatic vessel endothelial HA recptor-1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_053247.4 → NP_444477.2 lymphatic vessel endothelial hyaluronic acid receptor 1 precursor

See identical proteins and their annotated locations for NP_444477.2

Status: PROVISIONAL

Source sequence(s)

AC184052

Consensus CDS

CCDS21748.1

UniProtKB/Swiss-Prot

Q3TUC1, Q8BHC0, Q99NE4

Related

ENSMUSP00000033050.4, ENSMUST00000033050.5

Conserved Domains (1) summary

cd03516
Location:33 → 176

Link_domain_CD44_like; This domain is a hyaluronan (HA)-binding domain. It is found in CD44 receptor and mediates adhesive interactions during inflammatory leukocyte homing and tumor metastasis. It also plays an important role in arteriogenesis. The functional HA-binding ...