Macf1 microtubule-actin crosslinking factor 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Macf1provided by MGI
Official Full Name: microtubule-actin crosslinking factor 1provided by MGI
Primary source: MGI:MGI:108559
See related: Ensembl:ENSMUSG00000028649 AllianceGenome:MGI:108559
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Acf7; MACF; Aclp7; ABP620; mKIAA0465; mKIAA0754; D830031N03Rik
Summary: Enables ATP hydrolysis activity; actin binding activity; and microtubule binding activity. Involved in several processes, including positive regulation of Wnt signaling pathway; regulation of focal adhesion assembly; and regulation of neuron projection arborization. Acts upstream of or within several processes, including Wnt signaling pathway; mesoderm formation; and post-translational protein targeting to endoplasmic reticulum membrane. Located in cytoplasm; cytoskeleton; and postsynaptic density. Is expressed in several structures, including central nervous system; genitourinary system; limb segment; lung; and skeletal musculature. Human ortholog(s) of this gene implicated in lissencephaly 9 with complex brainstem malformation. Orthologous to human MACF1 (microtubule actin crosslinking factor 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Ubiquitous expression in lung adult (RPKM 15.9), CNS E18 (RPKM 10.5) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 4 D2.2; 4 57.42 cM

Exon count:: 109

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	4	NC_000070.7 (123243386..123581594, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	4	NC_000070.6 (123349633..123687802, complement)

Chromosome 4 - NC_000070.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

MSI1 Stabilizes MACF1 to Inhibit Apoptosis of MC3T3-E1 Cells Induced by High Glucose and Promote Osteogenic Differentiation Through Wnt/beta-Catenin Signaling Pathway.
Title: MSI1 Stabilizes MACF1 to Inhibit Apoptosis of MC3T3-E1 Cells Induced by High Glucose and Promote Osteogenic Differentiation Through Wnt/β-Catenin Signaling Pathway.
MACF1, Involved in the 1p34.2p34.3 Microdeletion Syndrome, is Essential in Cortical Progenitor Polarity and Brain Integrity.
Title: MACF1, Involved in the 1p34.2p34.3 Microdeletion Syndrome, is Essential in Cortical Progenitor Polarity and Brain Integrity.
MiR-138-5p Targets MACF1 to Aggravate Aging-related Bone Loss.
Title: MiR-138-5p Targets MACF1 to Aggravate Aging-related Bone Loss.
MACF1 promotes osteoblastic cell migration by regulating MAP1B through the GSK3beta/TCF7 pathway.
Title: MACF1 promotes osteoblastic cell migration by regulating MAP1B through the GSK3beta/TCF7 pathway.
MACF1 promotes osteoblast differentiation by sequestering repressors in cytoplasm.
Title: MACF1 promotes osteoblast differentiation by sequestering repressors in cytoplasm.
CircMACF1 Attenuates Acute Myocardial Infarction Through miR-500b-5p-EMP1 Axis.
Title: CircMACF1 Attenuates Acute Myocardial Infarction Through miR-500b-5p-EMP1 Axis.
MACF1 controls skeletal muscle function through the microtubule-dependent localization of extra-synaptic myonuclei and mitochondria biogenesis.
Title: MACF1 controls skeletal muscle function through the microtubule-dependent localization of extra-synaptic myonuclei and mitochondria biogenesis.
MACF1 promotes preosteoblast migration by mediating focal adhesion turnover through EB1.
Title: MACF1 promotes preosteoblast migration by mediating focal adhesion turnover through EB1.
Deficiency of Macf1 in osterix expressing cells decreases bone formation by Bmp2/Smad/Runx2 pathway.
Title: Deficiency of Macf1 in osterix expressing cells decreases bone formation by Bmp2/Smad/Runx2 pathway.
Mesenchymal MACF1 Facilitates SMAD7 Nuclear Translocation to Drive Bone Formation.
Title: Mesenchymal MACF1 Facilitates SMAD7 Nuclear Translocation to Drive Bone Formation.

Submit: New GeneRIF Correction See all GeneRIFs (31)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3) 1 citation
Targeted (4) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D4Dcr21 (e-PCR), detects polymorphism
- UniSTS:507695

D4Mit169 (e-PCR), detects polymorphism
- UniSTS:129948

RH125142 (e-PCR)
- UniSTS:161964

AA858740 (e-PCR)
- UniSTS:243421

SHGC-74638 (e-PCR)
- UniSTS:57569

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ATP hydrolysis activity	IDA Inferred from Direct Assay more info	PubMed
enables actin binding	IDA Inferred from Direct Assay more info	PubMed
enables actin binding	ISO Inferred from Sequence Orthology more info
enables actin filament binding	ISO Inferred from Sequence Orthology more info
enables actin filament binding	ISS Inferred from Sequence or Structural Similarity more info
enables calcium ion binding	IEA Inferred from Electronic Annotation more info
enables microtubule binding	IDA Inferred from Direct Assay more info	PubMed
enables microtubule minus-end binding	ISO Inferred from Sequence Orthology more info
enables microtubule minus-end binding	ISS Inferred from Sequence or Structural Similarity more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables structural molecule activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in Golgi to plasma membrane protein transport	ISO Inferred from Sequence Orthology more info
involved_in Golgi to plasma membrane protein transport	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within Wnt signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within Wnt signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within establishment or maintenance of cell polarity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in intermediate filament cytoskeleton organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in intermediate filament cytoskeleton organization	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within mesoderm formation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of Wnt signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of Wnt signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of axon extension	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within post-translational protein targeting to endoplasmic reticulum membrane	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within protein localization	ISO Inferred from Sequence Orthology more info
involved_in regulation of cell migration	ISO Inferred from Sequence Orthology more info
involved_in regulation of cell migration	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of epithelial cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of focal adhesion assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of focal adhesion assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of focal adhesion assembly	ISO Inferred from Sequence Orthology more info
involved_in regulation of focal adhesion assembly	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of microtubule-based process	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of microtubule-based process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of microtubule-based process	ISO Inferred from Sequence Orthology more info
involved_in regulation of microtubule-based process	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of neuron projection arborization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in wound healing	IBA Inferred from Biological aspect of Ancestor more info
involved_in wound healing	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in Golgi apparatus	ISO Inferred from Sequence Orthology more info
located_in Golgi apparatus	ISS Inferred from Sequence or Structural Similarity more info
is_active_in actin cytoskeleton	IBA Inferred from Biological aspect of Ancestor more info
located_in actin cytoskeleton	IDA Inferred from Direct Assay more info	PubMed
located_in cell cortex	ISO Inferred from Sequence Orthology more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
colocalizes_with intermediate filament	IBA Inferred from Biological aspect of Ancestor more info
is_active_in membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	ISO Inferred from Sequence Orthology more info
located_in membrane	ISS Inferred from Sequence or Structural Similarity more info
is_active_in microtubule	IBA Inferred from Biological aspect of Ancestor more info
located_in microtubule	IDA Inferred from Direct Assay more info	PubMed
located_in microtubule	ISO Inferred from Sequence Orthology more info
located_in microtubule cytoskeleton	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in postsynaptic density	IDA Inferred from Direct Assay more info	PubMed
located_in ruffle membrane	ISO Inferred from Sequence Orthology more info
located_in ruffle membrane	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: microtubule-actin cross-linking factor 1

Names: actin cross-linking family 7; actin-crosslinking protein 7; trabeculin alpha

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001199136.2 → NP_001186065.1 microtubule-actin cross-linking factor 1 isoform 1

Status: VALIDATED

Source sequence(s)

AL606918, AL606932

Consensus CDS

CCDS57295.1

UniProtKB/Swiss-Prot

B1ARU3, P97394, P97395, P97396, Q4PLL5, Q9QXZ0

UniProtKB/TrEMBL

B1ARU4, E9PVY8

Related

ENSMUSP00000101831.3, ENSMUST00000106224.9

Conserved Domains (8) summary

smart00243
Location:7081 → 7159

GAS2; Growth-Arrest-Specific Protein 2 Domain

smart00150
Location:6844 → 6968

SPEC; Spectrin repeats

cd00014
Location:79 → 181

CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...

cd00051
Location:7006 → 7068

EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

cd00176
Location:6182 → 6398

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

pfam00681
Location:1769 → 1809

Plectin; Plectin repeat

pfam13499
Location:7007 → 7067

EF-hand_7; EF-hand domain pair

cl02488
Location:5088 → 5303

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
NM_001199137.2 → NP_001186066.1 microtubule-actin cross-linking factor 1 isoform 2

Status: VALIDATED

Source sequence(s)

AL606918, AL606932

Consensus CDS

CCDS57294.1

UniProtKB/TrEMBL

A0A0A0MQA6, A0A571BGC6

Related

ENSMUSP00000080755.6, ENSMUST00000082108.12

Conserved Domains (7) summary

smart00243
Location:5054 → 5132

GAS2; Growth-Arrest-Specific Protein 2 Domain

smart00150
Location:4817 → 4941

SPEC; Spectrin repeats

cd00014
Location:79 → 181

CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...

cd00051
Location:4979 → 5041

EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

cd00176
Location:4155 → 4371

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

pfam13499
Location:4980 → 5040

EF-hand_7; EF-hand domain pair

cl02488
Location:3061 → 3276

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
NM_001401293.2 → NP_001388222.1 microtubule-actin cross-linking factor 1 isoform 3

Status: VALIDATED

Source sequence(s)

AL606918

UniProtKB/Swiss-Prot

Q69ZZ9
NM_001401294.2 → NP_001388223.1 microtubule-actin cross-linking factor 1 isoform 4

Status: VALIDATED

Source sequence(s)

AL606918

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000070.7 Reference GRCm39 C57BL/6J

Range

123243386..123581594 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_011240417.3 → XP_011238719.2 microtubule-actin cross-linking factor 1 isoform X9

UniProtKB/TrEMBL

F7ACR9

Conserved Domains (12) summary

smart00243
Location:5177 → 5249

GAS2; Growth-Arrest-Specific Protein 2 Domain

smart00150
Location:4944 → 5068

SPEC; Spectrin repeats

PHA03307
Location:5270 → 5443

PHA03307; transcriptional regulator ICP4; Provisional

COG0419
Location:1255 → 1726

SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]

COG1196
Location:2161 → 2978

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

COG4372
Location:1664 → 1862

COG4372; Uncharacterized conserved protein, contains DUF3084 domain [Function unknown]

COG5069
Location:109 → 333

SAC6; Ca2+-binding actin-bundling protein fimbrin/plastin (EF-Hand superfamily) [Cytoskeleton]

cd00051
Location:5102 → 5164

EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

cd00176
Location:4282 → 4498

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

TIGR02168
Location:2830 → 3760

SMC_prok_B; chromosome segregation protein SMC, common bacterial type

pfam17902
Location:893 → 959

SH3_10; SH3 domain

pfam18373
Location:994 → 1071

Spectrin_like; Spectrin like domain
XM_030253097.2 → XP_030108957.1 microtubule-actin cross-linking factor 1 isoform X10

UniProtKB/TrEMBL

A0A571BGC6

Conserved Domains (11) summary

smart00243
Location:5090 → 5168

GAS2; Growth-Arrest-Specific Protein 2 Domain

smart00150
Location:4853 → 4977

SPEC; Spectrin repeats

PHA03307
Location:5189 → 5362

PHA03307; transcriptional regulator ICP4; Provisional

COG1196
Location:2161 → 2999

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

COG5069
Location:109 → 333

SAC6; Ca2+-binding actin-bundling protein fimbrin/plastin (EF-Hand superfamily) [Cytoskeleton]

cd00051
Location:5015 → 5077

EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

cd00176
Location:4191 → 4407

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

TIGR02168
Location:2851 → 3672

SMC_prok_B; chromosome segregation protein SMC, common bacterial type

pfam15921
Location:1156 → 1908

CCDC158; Coiled-coil domain-containing protein 158

pfam17902
Location:893 → 959

SH3_10; SH3 domain

pfam18373
Location:994 → 1071

Spectrin_like; Spectrin like domain
XM_011240416.3 → XP_011238718.2 microtubule-actin cross-linking factor 1 isoform X7

UniProtKB/TrEMBL

F7ACR9

Related

ENSMUSP00000114568.2, ENSMUST00000151346.8

Conserved Domains (11) summary

smart00243
Location:5198 → 5270

GAS2; Growth-Arrest-Specific Protein 2 Domain

smart00150
Location:4965 → 5089

SPEC; Spectrin repeats

PHA03307
Location:5291 → 5464

PHA03307; transcriptional regulator ICP4; Provisional

COG1196
Location:2161 → 2999

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

COG5069
Location:109 → 333

SAC6; Ca2+-binding actin-bundling protein fimbrin/plastin (EF-Hand superfamily) [Cytoskeleton]

cd00051
Location:5123 → 5185

EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

cd00176
Location:4303 → 4519

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

TIGR02168
Location:2851 → 3781

SMC_prok_B; chromosome segregation protein SMC, common bacterial type

pfam15921
Location:1156 → 1908

CCDC158; Coiled-coil domain-containing protein 158

pfam17902
Location:893 → 959

SH3_10; SH3 domain

pfam18373
Location:994 → 1071

Spectrin_like; Spectrin like domain
XM_036163593.1 → XP_036019486.1 microtubule-actin cross-linking factor 1 isoform X6

UniProtKB/TrEMBL

F7ACR9

Conserved Domains (12) summary

smart00243
Location:5203 → 5278

GAS2; Growth-Arrest-Specific Protein 2 Domain

smart00150
Location:4965 → 5089

SPEC; Spectrin repeats

PHA03307
Location:5419 → 5534

PHA03307; transcriptional regulator ICP4; Provisional

COG1196
Location:2161 → 2999

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

cd00051
Location:5128 → 5190

EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

cd00176
Location:4303 → 4519

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

TIGR02168
Location:2851 → 3781

SMC_prok_B; chromosome segregation protein SMC, common bacterial type

pfam15921
Location:1156 → 1908

CCDC158; Coiled-coil domain-containing protein 158

pfam17902
Location:893 → 959

SH3_10; SH3 domain

pfam18373
Location:994 → 1071

Spectrin_like; Spectrin like domain

cd21188
Location:113 → 217

CH_PLEC-like_rpt1; first calponin homology (CH) domain found in the plectin/dystonin/MACF1 family

cl00030
Location:228 → 334

CH_SF; calponin homology (CH) domain superfamily
XM_036163597.1 → XP_036019490.1 microtubule-actin cross-linking factor 1 isoform X13

UniProtKB/Swiss-Prot

B1ARU3, P97394, P97395, P97396, Q4PLL5, Q9QXZ0

Conserved Domains (13) summary

smart00243
Location:7113 → 7188

GAS2; Growth-Arrest-Specific Protein 2 Domain

smart00150
Location:6880 → 7004

SPEC; Spectrin repeats

PHA03307
Location:7329 → 7444

PHA03307; transcriptional regulator ICP4; Provisional

COG1196
Location:4188 → 5026

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

cd00051
Location:7038 → 7100

EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

cd00176
Location:6218 → 6434

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

TIGR02168
Location:4878 → 5699

SMC_prok_B; chromosome segregation protein SMC, common bacterial type

pfam00681
Location:1805 → 1841

Plectin; Plectin repeat

pfam17902
Location:893 → 959

SH3_10; SH3 domain

pfam18373
Location:994 → 1071

Spectrin_like; Spectrin like domain

cd21188
Location:113 → 217

CH_PLEC-like_rpt1; first calponin homology (CH) domain found in the plectin/dystonin/MACF1 family

cd21240
Location:228 → 334

CH_MACF1_rpt2; second calponin homology (CH) domain found in microtubule-actin cross-linking factor 1, isoforms 1/2/3/5 (MACF1) and similar proteins

cl02488
Location:1200 → 1379

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
XM_030253096.2 → XP_030108956.1 microtubule-actin cross-linking factor 1 isoform X2

UniProtKB/Swiss-Prot

B1ARU3, P97394, P97395, P97396, Q4PLL5, Q9QXZ0

Conserved Domains (12) summary

smart00243
Location:7117 → 7195

GAS2; Growth-Arrest-Specific Protein 2 Domain

smart00150
Location:6880 → 7004

SPEC; Spectrin repeats

PHA03307
Location:7216 → 7389

PHA03307; transcriptional regulator ICP4; Provisional

COG1196
Location:4188 → 5026

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

COG5069
Location:109 → 333

SAC6; Ca2+-binding actin-bundling protein fimbrin/plastin (EF-Hand superfamily) [Cytoskeleton]

cd00051
Location:7042 → 7104

EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

cd00176
Location:6218 → 6434

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

TIGR02168
Location:4878 → 5699

SMC_prok_B; chromosome segregation protein SMC, common bacterial type

cl02488
Location:1200 → 1379

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

pfam00681
Location:1805 → 1845

Plectin; Plectin repeat

pfam17902
Location:893 → 959

SH3_10; SH3 domain

pfam18373
Location:994 → 1071

Spectrin_like; Spectrin like domain
XM_011240411.3 → XP_011238713.2 microtubule-actin cross-linking factor 1 isoform X3

UniProtKB/Swiss-Prot

B1ARU3, P97394, P97395, P97396, Q4PLL5, Q9QXZ0

Conserved Domains (12) summary

smart00243
Location:7116 → 7188

GAS2; Growth-Arrest-Specific Protein 2 Domain

smart00150
Location:6883 → 7007

SPEC; Spectrin repeats

PHA03307
Location:7209 → 7382

PHA03307; transcriptional regulator ICP4; Provisional

COG1196
Location:4188 → 5026

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

COG5069
Location:109 → 333

SAC6; Ca2+-binding actin-bundling protein fimbrin/plastin (EF-Hand superfamily) [Cytoskeleton]

cd00051
Location:7041 → 7103

EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

cd00176
Location:6221 → 6437

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

TIGR02168
Location:4878 → 5699

SMC_prok_B; chromosome segregation protein SMC, common bacterial type

cl02488
Location:1200 → 1379

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

pfam00681
Location:1805 → 1845

Plectin; Plectin repeat

pfam17902
Location:893 → 959

SH3_10; SH3 domain

pfam18373
Location:994 → 1071

Spectrin_like; Spectrin like domain
XM_036163600.1 → XP_036019493.1 microtubule-actin cross-linking factor 1 isoform X16

UniProtKB/Swiss-Prot

B1ARU3, P97394, P97395, P97396, Q4PLL5, Q9QXZ0

Conserved Domains (13) summary

smart00243
Location:7222 → 7294

GAS2; Growth-Arrest-Specific Protein 2 Domain

smart00150
Location:6989 → 7113

SPEC; Spectrin repeats

PHA03307
Location:7409 → 7524

PHA03307; transcriptional regulator ICP4; Provisional

COG1196
Location:4188 → 5026

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

cd00051
Location:7147 → 7209

EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

cd00176
Location:6327 → 6543

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

TIGR02168
Location:4878 → 5808

SMC_prok_B; chromosome segregation protein SMC, common bacterial type

pfam00681
Location:1805 → 1841

Plectin; Plectin repeat

pfam17902
Location:893 → 959

SH3_10; SH3 domain

pfam18373
Location:994 → 1071

Spectrin_like; Spectrin like domain

cd21188
Location:113 → 217

CH_PLEC-like_rpt1; first calponin homology (CH) domain found in the plectin/dystonin/MACF1 family

cd21240
Location:228 → 334

CH_MACF1_rpt2; second calponin homology (CH) domain found in microtubule-actin cross-linking factor 1, isoforms 1/2/3/5 (MACF1) and similar proteins

cl02488
Location:1200 → 1379

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
XM_036163599.1 → XP_036019492.1 microtubule-actin cross-linking factor 1 isoform X15

UniProtKB/Swiss-Prot

B1ARU3, P97394, P97395, P97396, Q4PLL5, Q9QXZ0

Conserved Domains (13) summary

smart00243
Location:7222 → 7300

GAS2; Growth-Arrest-Specific Protein 2 Domain

smart00150
Location:6989 → 7113

SPEC; Spectrin repeats

PHA03307
Location:7415 → 7530

PHA03307; transcriptional regulator ICP4; Provisional

COG1196
Location:4188 → 5026

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

cd00051
Location:7147 → 7209

EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

cd00176
Location:6327 → 6543

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

TIGR02168
Location:4878 → 5808

SMC_prok_B; chromosome segregation protein SMC, common bacterial type

pfam00681
Location:1805 → 1841

Plectin; Plectin repeat

pfam17902
Location:893 → 959

SH3_10; SH3 domain

pfam18373
Location:994 → 1071

Spectrin_like; Spectrin like domain

cd21188
Location:113 → 217

CH_PLEC-like_rpt1; first calponin homology (CH) domain found in the plectin/dystonin/MACF1 family

cd21240
Location:228 → 334

CH_MACF1_rpt2; second calponin homology (CH) domain found in microtubule-actin cross-linking factor 1, isoforms 1/2/3/5 (MACF1) and similar proteins

cl02488
Location:1200 → 1379

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
XM_036163598.1 → XP_036019491.1 microtubule-actin cross-linking factor 1 isoform X14

UniProtKB/Swiss-Prot

B1ARU3, P97394, P97395, P97396, Q4PLL5, Q9QXZ0

Conserved Domains (13) summary

smart00243
Location:7222 → 7297

GAS2; Growth-Arrest-Specific Protein 2 Domain

smart00150
Location:6989 → 7113

SPEC; Spectrin repeats

PHA03307
Location:7438 → 7553

PHA03307; transcriptional regulator ICP4; Provisional

COG1196
Location:4188 → 5026

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

cd00051
Location:7147 → 7209

EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

cd00176
Location:6327 → 6543

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

TIGR02168
Location:4878 → 5808

SMC_prok_B; chromosome segregation protein SMC, common bacterial type

pfam00681
Location:1805 → 1841

Plectin; Plectin repeat

pfam17902
Location:893 → 959

SH3_10; SH3 domain

pfam18373
Location:994 → 1071

Spectrin_like; Spectrin like domain

cd21188
Location:113 → 217

CH_PLEC-like_rpt1; first calponin homology (CH) domain found in the plectin/dystonin/MACF1 family

cd21240
Location:228 → 334

CH_MACF1_rpt2; second calponin homology (CH) domain found in microtubule-actin cross-linking factor 1, isoforms 1/2/3/5 (MACF1) and similar proteins

cl02488
Location:1200 → 1379

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
XM_036163596.1 → XP_036019489.1 microtubule-actin cross-linking factor 1 isoform X12

UniProtKB/Swiss-Prot

B1ARU3, P97394, P97395, P97396, Q4PLL5, Q9QXZ0

Conserved Domains (13) summary

smart00243
Location:7254 → 7332

GAS2; Growth-Arrest-Specific Protein 2 Domain

smart00150
Location:7021 → 7145

SPEC; Spectrin repeats

PHA03307
Location:7447 → 7562

PHA03307; transcriptional regulator ICP4; Provisional

COG1196
Location:4220 → 5058

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

cd00051
Location:7179 → 7241

EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

cd00176
Location:6359 → 6575

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

TIGR02168
Location:4910 → 5840

SMC_prok_B; chromosome segregation protein SMC, common bacterial type

pfam00681
Location:1837 → 1873

Plectin; Plectin repeat

pfam17902
Location:925 → 991

SH3_10; SH3 domain

pfam18373
Location:1026 → 1103

Spectrin_like; Spectrin like domain

cd21188
Location:113 → 249

CH_PLEC-like_rpt1; first calponin homology (CH) domain found in the plectin/dystonin/MACF1 family

cd21240
Location:260 → 366

CH_MACF1_rpt2; second calponin homology (CH) domain found in microtubule-actin cross-linking factor 1, isoforms 1/2/3/5 (MACF1) and similar proteins

cl02488
Location:1232 → 1411

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
XM_036163595.1 → XP_036019488.1 microtubule-actin cross-linking factor 1 isoform X11

UniProtKB/Swiss-Prot

B1ARU3, P97394, P97395, P97396, Q4PLL5, Q9QXZ0

Conserved Domains (13) summary

smart00243
Location:7254 → 7329

GAS2; Growth-Arrest-Specific Protein 2 Domain

smart00150
Location:7021 → 7145

SPEC; Spectrin repeats

PHA03307
Location:7470 → 7585

PHA03307; transcriptional regulator ICP4; Provisional

COG1196
Location:4220 → 5058

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

cd00051
Location:7179 → 7241

EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

cd00176
Location:6359 → 6575

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

TIGR02168
Location:4910 → 5840

SMC_prok_B; chromosome segregation protein SMC, common bacterial type

pfam00681
Location:1837 → 1873

Plectin; Plectin repeat

pfam17902
Location:925 → 991

SH3_10; SH3 domain

pfam18373
Location:1026 → 1103

Spectrin_like; Spectrin like domain

cd21188
Location:113 → 249

CH_PLEC-like_rpt1; first calponin homology (CH) domain found in the plectin/dystonin/MACF1 family

cd21240
Location:260 → 366

CH_MACF1_rpt2; second calponin homology (CH) domain found in microtubule-actin cross-linking factor 1, isoforms 1/2/3/5 (MACF1) and similar proteins

cl02488
Location:1232 → 1411

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
XM_036163594.1 → XP_036019487.1 microtubule-actin cross-linking factor 1 isoform X8

UniProtKB/TrEMBL

F7ACR9

Conserved Domains (12) summary

smart00243
Location:5125 → 5200

GAS2; Growth-Arrest-Specific Protein 2 Domain

smart00150
Location:4887 → 5011

SPEC; Spectrin repeats

PHA03307
Location:5341 → 5456

PHA03307; transcriptional regulator ICP4; Provisional

COG1196
Location:2083 → 2921

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

cd00051
Location:5050 → 5112

EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

cd00176
Location:4225 → 4441

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

TIGR02168
Location:2773 → 3703

SMC_prok_B; chromosome segregation protein SMC, common bacterial type

pfam15921
Location:1078 → 1830

CCDC158; Coiled-coil domain-containing protein 158

pfam17902
Location:815 → 881

SH3_10; SH3 domain

pfam18373
Location:916 → 993

Spectrin_like; Spectrin like domain

cd21236
Location:21 → 148

CH_DYST_rpt1; first calponin homology (CH) domain found in dystonin and similar proteins

cl00030
Location:150 → 256

CH_SF; calponin homology (CH) domain superfamily
XM_036163591.1 → XP_036019484.1 microtubule-actin cross-linking factor 1 isoform X4

UniProtKB/TrEMBL

F7ACR9

Conserved Domains (11) summary

smart00243
Location:5318 → 5393

GAS2; Growth-Arrest-Specific Protein 2 Domain

smart00150
Location:5080 → 5204

SPEC; Spectrin repeats

PHA03307
Location:5534 → 5649

PHA03307; transcriptional regulator ICP4; Provisional

COG1196
Location:2276 → 3114

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

cd00051
Location:5243 → 5305

EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

cd00176
Location:4418 → 4634

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

TIGR02168
Location:2966 → 3896

SMC_prok_B; chromosome segregation protein SMC, common bacterial type

pfam15921
Location:1072 → 2023

CCDC158; Coiled-coil domain-containing protein 158

pfam17902
Location:1008 → 1074

SH3_10; SH3 domain

pfam18373
Location:1109 → 1186

Spectrin_like; Spectrin like domain

cl00030
Location:343 → 449

CH_SF; calponin homology (CH) domain superfamily
XM_036163592.1 → XP_036019485.1 microtubule-actin cross-linking factor 1 isoform X5

UniProtKB/TrEMBL

F7ACR9

Conserved Domains (12) summary

smart00243
Location:5299 → 5374

GAS2; Growth-Arrest-Specific Protein 2 Domain

smart00150
Location:5061 → 5185

SPEC; Spectrin repeats

PHA03307
Location:5515 → 5630

PHA03307; transcriptional regulator ICP4; Provisional

COG0419
Location:1372 → 1843

SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]

COG1196
Location:2278 → 3095

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

COG4372
Location:1781 → 1979

COG4372; Uncharacterized conserved protein, contains DUF3084 domain [Function unknown]

cd00051
Location:5224 → 5286

EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

cd00176
Location:4399 → 4615

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

TIGR02168
Location:2947 → 3877

SMC_prok_B; chromosome segregation protein SMC, common bacterial type

pfam17902
Location:1010 → 1076

SH3_10; SH3 domain

pfam18373
Location:1111 → 1188

Spectrin_like; Spectrin like domain

cl00030
Location:343 → 449

CH_SF; calponin homology (CH) domain superfamily
XM_036163590.1 → XP_036019483.1 microtubule-actin cross-linking factor 1 isoform X1

UniProtKB/Swiss-Prot

B1ARU3, P97394, P97395, P97396, Q4PLL5, Q9QXZ0

Conserved Domains (12) summary

smart00243
Location:7342 → 7420

GAS2; Growth-Arrest-Specific Protein 2 Domain

smart00150
Location:7109 → 7233

SPEC; Spectrin repeats

PHA03307
Location:7441 → 7614

PHA03307; transcriptional regulator ICP4; Provisional

COG1196
Location:4305 → 5143

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

cd00051
Location:7267 → 7329

EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

cd00176
Location:6447 → 6663

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

TIGR02168
Location:4995 → 5925

SMC_prok_B; chromosome segregation protein SMC, common bacterial type

pfam00681
Location:1922 → 1958

Plectin; Plectin repeat

pfam17902
Location:1010 → 1076

SH3_10; SH3 domain

pfam18373
Location:1111 → 1188

Spectrin_like; Spectrin like domain

cd21240
Location:343 → 449

CH_MACF1_rpt2; second calponin homology (CH) domain found in microtubule-actin cross-linking factor 1, isoforms 1/2/3/5 (MACF1) and similar proteins

cl02488
Location:1317 → 1496

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_001167918.1: Suppressed sequence

Description

NM_001167918.1: This RefSeq was removed because currently there is insufficient support for the transcript.
NM_009600.3: Suppressed sequence

Description

NM_009600.3: This RefSeq was removed because currently there is insufficient support for the transcript.