Aatk apoptosis-associated tyrosine kinase [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Aatkprovided by MGI
Official Full Name: apoptosis-associated tyrosine kinaseprovided by MGI
Primary source: MGI:MGI:1197518
See related: Ensembl:ENSMUSG00000025375 AllianceGenome:MGI:1197518
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: AATYK; aatyk1; mKIAA0641
Summary: Enables protein tyrosine kinase activity. Acts upstream of or within brain development; neuron apoptotic process; and peptidyl-tyrosine autophosphorylation. Predicted to be located in several cellular components, including dendrite; growth cone; and perinuclear region of cytoplasm. Is expressed in brain; corpus callosum; spinal cord; spinal cord gray matter; and spinal cord white matter. Orthologous to human AATK (apoptosis associated tyrosine kinase). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Broad expression in cerebellum adult (RPKM 51.8), cortex adult (RPKM 38.4) and 15 other tissues See more
Orthologs: human all
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Genomic context

Location:: 11 E2; 11 83.96 cM

Exon count:: 16

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	11	NC_000077.7 (119898137..119938009, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	11	NC_000077.6 (120007311..120047183, complement)

Chromosome 11 - NC_000077.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Epigenetic silencing of AATK in acinar to ductal metaplasia in murine model of pancreatic cancer.
Title: Epigenetic silencing of AATK in acinar to ductal metaplasia in murine model of pancreatic cancer.
Isoform-dependent subcellular localization of LMTK1A and LMTK1B and their roles in axon outgrowth and spine formation.
Title: Isoform-dependent subcellular localization of LMTK1A and LMTK1B and their roles in axon outgrowth and spine formation.
The results showed that AATYK knockdown inhibited Oligodendrocytes differentiation and the expression of myelin genes in vitro.
Title: AATYK is a Novel Regulator of Oligodendrocyte Differentiation and Myelination.
LMTK1 negatively controls dendritic formation by regulating Rab11A-positive endosomal trafficking.
Title: LMTK1 regulates dendritic formation by regulating movement of Rab11A-positive endosomes.
Overexpression of the unphosphorylated mutant LMTK1-S34A dramatically promotes axonal outgrowth in cultured neurons.
Title: LMTK1/AATYK1 is a novel regulator of axonal outgrowth that acts via Rab11 in a Cdk5-dependent manner.
results suggest a possibility that AATYK1A plays a role in early to recycling endosomes and its function is regulated by phosphorylation with Cdk5 or Src-family kinases
Title: Phosphorylation of AATYK1 by Cdk5 suppresses its tyrosine phosphorylation.
Expression of AATYK mRNA and protein increased during postnatal brain development. In immature granule cells, overexpression of AATYK promoted neurite outgrowth; a tyrosine kinase-defective mutant significantly inhibited it.
Title: Differential expression and function of apoptosis-associated tyrosine kinase (AATYK) in the developing mouse brain.
AATYK1 indirectly inhibits the SPAK/WNK4 activation of the Na-K-2Cl cotransporter by scaffolding an inhibitory phosphatase in proximity to a stimulatory kinase.
Title: Apoptosis-associated tyrosine kinase scaffolding of protein phosphatase 1 and SPAK reveals a novel pathway for Na-K-2C1 cotransporter regulation.
phosphorylation states of AATYK are closely related to the high potassium-induced survival and low potassium-induced apoptosis of cerebellar granule cells
Title: Apoptosis-associated tyrosine kinase (AATYK) has differential Ca2+-dependent phosphorylation states in response to survival and apoptotic conditions in cerebellar granule cells.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Targeted (2) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables 3-phosphoinositide-dependent protein kinase activity	IEA Inferred from Electronic Annotation more info
enables AMP-activated protein kinase activity	IEA Inferred from Electronic Annotation more info
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables DNA-dependent protein kinase activity	IEA Inferred from Electronic Annotation more info
enables Rho-dependent protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info
enables eukaryotic translation initiation factor 2alpha kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AS1 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AS121 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AT120 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AXS139 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2BS14 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2BS36 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3S10 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3S28 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3S57 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T11 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T3 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T45 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T6 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H4S1 kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine kinase activity	IEA Inferred from Electronic Annotation more info
enables protein tyrosine kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein tyrosine kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables ribosomal protein S6 kinase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within apoptotic process	IDA Inferred from Direct Assay more info	PubMed
involved_in brain development	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within brain development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in chromatin remodeling	IEA Inferred from Electronic Annotation more info
involved_in neuron apoptotic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within neuron apoptotic process	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within peptidyl-tyrosine autophosphorylation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within peptidyl-tyrosine autophosphorylation	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in dendrite	IEA Inferred from Electronic Annotation more info
located_in growth cone	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in perinuclear region of cytoplasm	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: serine/threonine-protein kinase LMTK1

Names: apoptosis-associated tyrosine kinase 1B; brain apoptosis-associated tyrosine kinase; lemur tyrosine kinase 1

NP_001185714.1

EC 2.7.11.1

NP_001185716.1

EC 2.7.11.1

NP_001364432.1

EC 2.7.11.1

NP_001389718.1

EC 2.7.11.1

NP_031403.2

EC 2.7.11.1

XP_006532054.1

EC 2.7.11.1

XP_006532055.1

EC 2.7.11.1

XP_006532056.1

EC 2.7.11.1

XP_006532057.1

EC 2.7.11.1

XP_036012124.1

EC 2.7.11.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001198785.1 → NP_001185714.1 serine/threonine-protein kinase LMTK1 isoform 2

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR and contains an in-frame upstream start codon compared to variant 1. This variant encodes a protein (isoform 2) with a longer N-terminus than isoform 1.

Source sequence(s)

AB288871, BC042837, BC080846

Consensus CDS

CCDS56826.1

UniProtKB/Swiss-Prot

A6BLY8, O35211, Q3U2U5, Q3UHR8, Q66JN3, Q80YE3, Q80YE4, Q8CB63, Q8CHE2

UniProtKB/TrEMBL

B1AZF3

Related

ENSMUSP00000067181.4, ENSMUST00000064307.10

Conserved Domains (3) summary

smart00221
Location:138 → 405

STYKc; Protein kinase; unclassified specificity

cd05087
Location:137 → 407

PTKc_Aatyk1; Catalytic domain of the Protein Tyrosine Kinases, Apoptosis-associated tyrosine kinase 1

pfam12429
Location:828 → 880

DUF3676; Protein of unknown function (DUF3676)
NM_001198787.1 → NP_001185716.1 serine/threonine-protein kinase LMTK1 isoform 1

See identical proteins and their annotated locations for NP_001185716.1

Status: VALIDATED

Description

Transcript Variant: This variant (3) differs in the 5' UTR, compared to variant, and encodes isoform 1. Variants 1 and 3 encode the same protein (isoform 1).

Source sequence(s)

AK036705, BC080846

Consensus CDS

CCDS25725.1

UniProtKB/Swiss-Prot

A6BLY8, O35211, Q3U2U5, Q3UHR8, Q66JN3, Q80YE3, Q80YE4, Q8CB63, Q8CHE2

UniProtKB/TrEMBL

B1AZF9

Related

ENSMUSP00000099308.2, ENSMUST00000103019.2

Conserved Domains (3) summary

smart00221
Location:81 → 348

STYKc; Protein kinase; unclassified specificity

cd05087
Location:80 → 350

PTKc_Aatyk1; Catalytic domain of the Protein Tyrosine Kinases, Apoptosis-associated tyrosine kinase 1

pfam12429
Location:771 → 823

DUF3676; Protein of unknown function (DUF3676)
NM_001377503.1 → NP_001364432.1 serine/threonine-protein kinase LMTK1 isoform 3

Status: VALIDATED

Source sequence(s)

AL953913

UniProtKB/Swiss-Prot

A6BLY8, O35211, Q3U2U5, Q3UHR8, Q66JN3, Q80YE3, Q80YE4, Q8CB63, Q8CHE2

Conserved Domains (2) summary

PHA03307
Location:473 → 904

PHA03307; transcriptional regulator ICP4; Provisional

cl21453
Location:1 → 230

PKc_like; Protein Kinases, catalytic domain
NM_001402789.1 → NP_001389718.1 serine/threonine-protein kinase LMTK1 isoform 4

Status: VALIDATED

Source sequence(s)

AL953913
NM_007377.4 → NP_031403.2 serine/threonine-protein kinase LMTK1 isoform 1

See identical proteins and their annotated locations for NP_031403.2

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes isoform 1. Variants 1 and 3 encode the same protein (isoform 1).

Source sequence(s)

BC042837, BC080846

Consensus CDS

CCDS25725.1

UniProtKB/Swiss-Prot

A6BLY8, O35211, Q3U2U5, Q3UHR8, Q66JN3, Q80YE3, Q80YE4, Q8CB63, Q8CHE2

UniProtKB/TrEMBL

B1AZF9

Related

ENSMUSP00000099309.2, ENSMUST00000103020.8

Conserved Domains (3) summary

smart00221
Location:81 → 348

STYKc; Protein kinase; unclassified specificity

cd05087
Location:80 → 350

PTKc_Aatyk1; Catalytic domain of the Protein Tyrosine Kinases, Apoptosis-associated tyrosine kinase 1

pfam12429
Location:771 → 823

DUF3676; Protein of unknown function (DUF3676)

RNA

NR_165305.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

AL953913
NR_165306.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

AL953913
NR_175298.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

AL953913

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000077.7 Reference GRCm39 C57BL/6J

Range

119898137..119938009 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006531991.3 → XP_006532054.1 serine/threonine-protein kinase LMTK1 isoform X1

UniProtKB/Swiss-Prot

A6BLY8, O35211, Q3U2U5, Q3UHR8, Q66JN3, Q80YE3, Q80YE4, Q8CB63, Q8CHE2

Conserved Domains (2) summary

PHA03307
Location:650 → 1081

PHA03307; transcriptional regulator ICP4; Provisional

cd05087
Location:137 → 407

PTKc_Aatyk1; Catalytic domain of the Protein Tyrosine Kinases, Apoptosis-associated tyrosine kinase 1
XM_006531993.3 → XP_006532056.1 serine/threonine-protein kinase LMTK1 isoform X4

See identical proteins and their annotated locations for XP_006532056.1

UniProtKB/Swiss-Prot

A6BLY8, O35211, Q3U2U5, Q3UHR8, Q66JN3, Q80YE3, Q80YE4, Q8CB63, Q8CHE2

Related

ENSMUST00000150730.8

Conserved Domains (2) summary

PHA03307
Location:593 → 1024

PHA03307; transcriptional regulator ICP4; Provisional

cd05087
Location:80 → 350

PTKc_Aatyk1; Catalytic domain of the Protein Tyrosine Kinases, Apoptosis-associated tyrosine kinase 1
XM_006531994.4 → XP_006532057.1 serine/threonine-protein kinase LMTK1 isoform X4

See identical proteins and their annotated locations for XP_006532057.1

UniProtKB/Swiss-Prot

A6BLY8, O35211, Q3U2U5, Q3UHR8, Q66JN3, Q80YE3, Q80YE4, Q8CB63, Q8CHE2

Conserved Domains (2) summary

PHA03307
Location:593 → 1024

PHA03307; transcriptional regulator ICP4; Provisional

cd05087
Location:80 → 350

PTKc_Aatyk1; Catalytic domain of the Protein Tyrosine Kinases, Apoptosis-associated tyrosine kinase 1
XM_006531992.5 → XP_006532055.1 serine/threonine-protein kinase LMTK1 isoform X2

UniProtKB/Swiss-Prot

A6BLY8, O35211, Q3U2U5, Q3UHR8, Q66JN3, Q80YE3, Q80YE4, Q8CB63, Q8CHE2

Conserved Domains (2) summary

PHA03307
Location:601 → 1032

PHA03307; transcriptional regulator ICP4; Provisional

cd05087
Location:88 → 358

PTKc_Aatyk1; Catalytic domain of the Protein Tyrosine Kinases, Apoptosis-associated tyrosine kinase 1
XM_036156231.1 → XP_036012124.1 serine/threonine-protein kinase LMTK1 isoform X5

Related

ENSMUST00000142959.2

Conserved Domains (1) summary

PHA03307
Location:240 → 671

PHA03307; transcriptional regulator ICP4; Provisional