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    PCLO piccolo presynaptic cytomatrix protein [ Numida meleagris (helmeted guineafowl) ]

    Gene ID: 110392305, updated on 15-Mar-2024

    Summary

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    Gene symbol
    PCLO
    Gene description
    piccolo presynaptic cytomatrix protein
    See related
    Ensembl:ENSNMEG00000003537
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Numida meleagris
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Numididae; Numida
    Orthologs
    human mouse all
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    Genomic context

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    See PCLO in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    26
    Annotation release Status Assembly Chr Location
    100 current NumMel1.0 (GCF_002078875.1) 1 NC_034409.1 (9424085..9767124)

    Chromosome 1 - NC_034409.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC110392487 Neighboring gene semaphorin 3E Neighboring gene calcium voltage-gated channel auxiliary subunit alpha2delta 1 Neighboring gene uncharacterized LOC110392310 Neighboring gene uncharacterized LOC110392312

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_034409.1 Chromosome 1 Reference NumMel1.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    2. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables protein binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables structural constituent of presynaptic active zone IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in presynaptic active zone assembly IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in protein localization to synapse IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in GABA-ergic synapse IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in axon IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in cytoskeleton of presynaptic active zone IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in glutamatergic synapse IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    protein piccolo

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Numida meleagris Annotation Release 100 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference NumMel1.0 Primary Assembly

    Genomic

    1. NC_034409.1 Reference NumMel1.0 Primary Assembly

      Range
      9424085..9767124
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_021384447.1 → XP_021240122.1  protein piccolo isoform X1

      Related
      ENSNMEP00000002951.1, ENSNMET00000005649.1
      Conserved Domains (9) summary
      cd04031
      Location:4751 → 4876
      C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
      cd00992
      Location:4567 → 4645
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd15774
      Location:446 → 507
      FYVE1_PCLO; FYVE-related domain 1 found in protein piccolo
      cd15776
      Location:914 → 977
      FYVE2_PCLO; FYVE-related domain 2 found in protein piccolo
      pfam07946
      Location:3776 → 3839
      DUF1682; Protein of unknown function (DUF1682)
      cl14603
      Location:5118 → 5243
      C2; C2 domain
      cl26464
      Location:232 → 862
      Atrophin-1; Atrophin-1 family
      cl26511
      Location:1022 → 1643
      Neuromodulin_N; Gap junction protein N-terminal region
      cl28087
      Location:162 → 299
      FtsK; DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell cycle control, cell division, chromosome partitioning]

    2. XM_021384450.1 → XP_021240125.1  protein piccolo isoform X4

      Conserved Domains (9) summary
      cd04031
      Location:4751 → 4876
      C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
      cd00992
      Location:4567 → 4645
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd15774
      Location:446 → 507
      FYVE1_PCLO; FYVE-related domain 1 found in protein piccolo
      cd15776
      Location:914 → 977
      FYVE2_PCLO; FYVE-related domain 2 found in protein piccolo
      pfam07946
      Location:3776 → 3839
      DUF1682; Protein of unknown function (DUF1682)
      cl14603
      Location:5082 → 5207
      C2; C2 domain
      cl26464
      Location:232 → 862
      Atrophin-1; Atrophin-1 family
      cl26511
      Location:1022 → 1643
      Neuromodulin_N; Gap junction protein N-terminal region
      cl28087
      Location:162 → 299
      FtsK; DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell cycle control, cell division, chromosome partitioning]

    3. XM_021384451.1 → XP_021240126.1  protein piccolo isoform X5

      Related
      ENSNMEP00000002954.1, ENSNMET00000005652.1
      Conserved Domains (9) summary
      cd04031
      Location:4751 → 4876
      C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
      cd00992
      Location:4567 → 4645
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd15774
      Location:446 → 507
      FYVE1_PCLO; FYVE-related domain 1 found in protein piccolo
      cd15776
      Location:914 → 977
      FYVE2_PCLO; FYVE-related domain 2 found in protein piccolo
      pfam07946
      Location:3776 → 3839
      DUF1682; Protein of unknown function (DUF1682)
      cl14603
      Location:5057 → 5182
      C2; C2 domain
      cl26464
      Location:232 → 862
      Atrophin-1; Atrophin-1 family
      cl26511
      Location:1022 → 1643
      Neuromodulin_N; Gap junction protein N-terminal region
      cl28087
      Location:162 → 299
      FtsK; DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell cycle control, cell division, chromosome partitioning]

    4. XM_021384452.1 → XP_021240127.1  protein piccolo isoform X6

      Related
      ENSNMEP00000002956.1, ENSNMET00000005654.1
      Conserved Domains (9) summary
      cd04031
      Location:4751 → 4876
      C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
      cd00992
      Location:4567 → 4645
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd15774
      Location:446 → 507
      FYVE1_PCLO; FYVE-related domain 1 found in protein piccolo
      cd15776
      Location:914 → 977
      FYVE2_PCLO; FYVE-related domain 2 found in protein piccolo
      pfam07946
      Location:3776 → 3839
      DUF1682; Protein of unknown function (DUF1682)
      cl14603
      Location:4992 → 5117
      C2; C2 domain
      cl26464
      Location:232 → 862
      Atrophin-1; Atrophin-1 family
      cl26511
      Location:1022 → 1643
      Neuromodulin_N; Gap junction protein N-terminal region
      cl28087
      Location:162 → 299
      FtsK; DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell cycle control, cell division, chromosome partitioning]

    5. XM_021384448.1 → XP_021240123.1  protein piccolo isoform X2

      Conserved Domains (9) summary
      cd04031
      Location:4750 → 4875
      C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
      cd00992
      Location:4567 → 4645
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd15774
      Location:446 → 507
      FYVE1_PCLO; FYVE-related domain 1 found in protein piccolo
      cd15776
      Location:914 → 977
      FYVE2_PCLO; FYVE-related domain 2 found in protein piccolo
      pfam07946
      Location:3776 → 3839
      DUF1682; Protein of unknown function (DUF1682)
      cl14603
      Location:5117 → 5242
      C2; C2 domain
      cl26464
      Location:232 → 862
      Atrophin-1; Atrophin-1 family
      cl26511
      Location:1022 → 1643
      Neuromodulin_N; Gap junction protein N-terminal region
      cl28087
      Location:162 → 299
      FtsK; DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell cycle control, cell division, chromosome partitioning]

    6. XM_021384449.1 → XP_021240124.1  protein piccolo isoform X3

      Related
      ENSNMEP00000002952.1, ENSNMET00000005650.1
      Conserved Domains (9) summary
      cd04031
      Location:4720 → 4845
      C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
      cd00992
      Location:4536 → 4614
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd15774
      Location:446 → 507
      FYVE1_PCLO; FYVE-related domain 1 found in protein piccolo
      cd15776
      Location:914 → 977
      FYVE2_PCLO; FYVE-related domain 2 found in protein piccolo
      pfam07946
      Location:3776 → 3839
      DUF1682; Protein of unknown function (DUF1682)
      cl14603
      Location:5087 → 5212
      C2; C2 domain
      cl26464
      Location:232 → 862
      Atrophin-1; Atrophin-1 family
      cl26511
      Location:1022 → 1643
      Neuromodulin_N; Gap junction protein N-terminal region
      cl28087
      Location:162 → 299
      FtsK; DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell cycle control, cell division, chromosome partitioning]

    7. XM_021384455.1 → XP_021240130.1  protein piccolo isoform X8

      Conserved Domains (9) summary
      cd04031
      Location:4720 → 4845
      C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
      cd00992
      Location:4536 → 4614
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd15774
      Location:446 → 507
      FYVE1_PCLO; FYVE-related domain 1 found in protein piccolo
      cd15776
      Location:914 → 977
      FYVE2_PCLO; FYVE-related domain 2 found in protein piccolo
      pfam07946
      Location:3776 → 3839
      DUF1682; Protein of unknown function (DUF1682)
      cl14603
      Location:5026 → 5151
      C2; C2 domain
      cl26464
      Location:232 → 862
      Atrophin-1; Atrophin-1 family
      cl26511
      Location:1022 → 1643
      Neuromodulin_N; Gap junction protein N-terminal region
      cl28087
      Location:162 → 299
      FtsK; DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell cycle control, cell division, chromosome partitioning]

    8. XM_021384454.1 → XP_021240129.1  protein piccolo isoform X7

      Conserved Domains (7) summary
      cd00992
      Location:4567 → 4639
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd15774
      Location:446 → 507
      FYVE1_PCLO; FYVE-related domain 1 found in protein piccolo
      cd15776
      Location:914 → 977
      FYVE2_PCLO; FYVE-related domain 2 found in protein piccolo
      pfam07946
      Location:3776 → 3839
      DUF1682; Protein of unknown function (DUF1682)
      cl26386
      Location:30 → 391
      DNA_pol3_gamma3; DNA polymerase III subunits gamma and tau domain III
      cl26464
      Location:232 → 862
      Atrophin-1; Atrophin-1 family
      cl26511
      Location:1022 → 1643
      Neuromodulin_N; Gap junction protein N-terminal region

    9. XM_021384453.1 → XP_021240128.1  protein piccolo isoform X7

      Conserved Domains (7) summary
      cd00992
      Location:4567 → 4639
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd15774
      Location:446 → 507
      FYVE1_PCLO; FYVE-related domain 1 found in protein piccolo
      cd15776
      Location:914 → 977
      FYVE2_PCLO; FYVE-related domain 2 found in protein piccolo
      pfam07946
      Location:3776 → 3839
      DUF1682; Protein of unknown function (DUF1682)
      cl26386
      Location:30 → 391
      DNA_pol3_gamma3; DNA polymerase III subunits gamma and tau domain III
      cl26464
      Location:232 → 862
      Atrophin-1; Atrophin-1 family
      cl26511
      Location:1022 → 1643
      Neuromodulin_N; Gap junction protein N-terminal region
    Nucleotide Protein
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