U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination
    • Showing Current items.

    LOC110386951 CYP19A1 promoter II/1.3 [ Homo sapiens (human) ]

    Gene ID: 110386951, updated on 10-Dec-2024

    Summary

    Go to the top of the page Help
    Gene symbol
    LOC110386951
    Gene description
    CYP19A1 promoter II/1.3
    Gene type
    biological region
    Feature type(s)
    protein_bind
    regulatory: promoter, silencer, transcriptional_cis_regulatory_region
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    This region encompasses multiple alternate promoters of the CYP19A1 (cytochrome P450 family 19 subfamily A member 1) gene, also known as aromatase. It contains a promoter region that can drive expression of a transgene in gonadal tissues, as well as multiple silencer elements. This region is induced by cyclic AMP and regulated by estrogen, leptin, calcitriol, retinoids, and prostaglandin. A hexameric nuclear receptor half-site motif binds members of the nuclear hormone receptor family, which regulate expression of this region in conjunction with nearby sites that bind cAMP responsive element binding protein 1, CCAAT/enhancer binding proteins, and AP-1 family transcription factors. [provided by RefSeq, Jun 2017]
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See LOC110386951 in Genome Data Viewer
    Location:
    chromosome: 15
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 15 NC_000015.10 (51242868..51244050)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 15 NC_060939.1 (49050640..49051822)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (51535065..51536247)

    Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene MIR4713 host gene Neighboring gene TNF alpha induced protein 8 like 3 Neighboring gene uncharacterized LOC124903492 Neighboring gene Sharpr-MPRA regulatory region 3311 Neighboring gene cytochrome P450 family 19 subfamily A member 1 Neighboring gene Sharpr-MPRA regulatory regions 2939 and 12041 Neighboring gene microRNA 4713 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:51559063-51559696 Neighboring gene CYP19A1 promoter I.7 Neighboring gene uncharacterized LOC124903493 Neighboring gene microRNA 7973-2 Neighboring gene microRNA 7973-1

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Forskolin up-regulates aromatase (CYP19) activity and gene transcripts in the human adrenocortical carcinoma cell line H295R. Watanabe M, et al. J Endocrinol, 2004 Jan. PMID 14709151
    2. Malignant breast epithelial cells stimulate aromatase expression via promoter II in human adipose fibroblasts: an epithelial-stromal interaction in breast tumors mediated by CCAAT/enhancer binding protein beta. Zhou J, et al. Cancer Res, 2001 Mar 1. PMID 11280806
    3. Regulation of aromatase promoter activity in human breast tissue by nuclear receptors. Yang C, et al. Oncogene, 2002 Apr 25. PMID 11973645
    4. Evaluation of a bioluminescent mouse model expressing aromatase PII-promoter-controlled luciferase as a tool for the study of endocrine disrupting chemicals. Rivest P, et al. Toxicol Appl Pharmacol, 2010 Nov 15. PMID 20723554
    5. The role of cyclooxygenase-2-dependent signaling via cyclic AMP response element activation on aromatase up-regulation by o,p'-DDT in human breast cancer cells. Han EH, et al. Toxicol Lett, 2010 Oct 20. PMID 20678559

    See all (85) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Phenotypes

    Go to the top of the page Help

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

    Go to the top of the page Help

    See variants in ClinVar

    See Variation Viewer (GRCh37.p13)

    General gene information

    Go to the top of the page Help

    Other Names

    • CYP19A1 promoter I.3
    • CYP19A1 promoter I.6
    • CYP19A1 promoter II
    • aromatase P450 promoter II
    • aromatase promoter II/I.3

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_055001.1 

      Range
      101..1283
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000015.10 Reference GRCh38.p14 Primary Assembly

      Range
      51242868..51244050
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060939.1 Alternate T2T-CHM13v2.0

      Range
      49050640..49051822
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases