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    Kif22 kinesin family member 22 [ Mus musculus (house mouse) ]

    Gene ID: 110033, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Kif22provided by MGI
    Official Full Name
    kinesin family member 22provided by MGI
    Primary source
    MGI:MGI:109233
    See related
    Ensembl:ENSMUSG00000030677 AllianceGenome:MGI:109233
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Kid; Kif22a
    Summary
    Predicted to enable ATP hydrolysis activity; microtubule binding activity; and microtubule motor activity. Predicted to be involved in microtubule-based movement; mitotic metaphase chromosome alignment; and sister chromatid cohesion. Located in chromatin and spindle. Is expressed in cerebral cortex ventricular layer; cortical plate; and inner cell mass. Human ortholog(s) of this gene implicated in spondyloepimetaphyseal dysplasia with joint laxity type 2. Orthologous to human KIF22 (kinesin family member 22). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in CNS E11.5 (RPKM 35.8), liver E14 (RPKM 33.5) and 13 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Kif22 in Genome Data Viewer
    Location:
    7 F3; 7 69.29 cM
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (126626901..126641639, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (127027729..127042467, complement)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E2850 Neighboring gene proline-rich transmembrane protein 2 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:134167876-134168063 Neighboring gene predicted gene, 53372 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:134170996-134171192 Neighboring gene STARR-seq mESC enhancer starr_20164 Neighboring gene MYC-associated zinc finger protein (purine-binding transcription factor) Neighboring gene STARR-positive B cell enhancer ABC_E9708 Neighboring gene zymogen granule protein 16 Neighboring gene STARR-positive B cell enhancer ABC_E8210 Neighboring gene predicted gene, 22747

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. KIF22 regulates mitosis and proliferation of chondrocyte cells. Kawaue H, et al. iScience, 2024 Jul 19. PMID 38989461, Free PMC Article
    2. The microtubule-binding and coiled-coil domains of Kid are required to turn off the polar ejection force at anaphase. Soeda S, et al. J Cell Sci, 2016 Oct 1. PMID 27550518
    3. Kid-mediated chromosome compaction ensures proper nuclear envelope formation. Ohsugi M, et al. Cell, 2008 Mar 7. PMID 18329364
    4. The second microtubule-binding site of monomeric kid enhances the microtubule affinity. Shiroguchi K, et al. J Biol Chem, 2003 Jun 20. PMID 12692123
    5. The ubiquitin ligase component Siah1a is required for completion of meiosis I in male mice. Dickins RA, et al. Mol Cell Biol, 2002 Apr. PMID 11884614, Free PMC Article

    See all (36) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Gene trapped (1) 
    • Targeted (2)  1 citation

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables microtubule binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables microtubule binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables microtubule motor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables microtubule motor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA repair IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in metaphase chromosome alignment ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in metaphase chromosome alignment ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in microtubule-based movement IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in microtubule-based movement IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mitotic metaphase chromosome alignment ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in mitotic metaphase chromosome alignment ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in sister chromatid cohesion ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in sister chromatid cohesion ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in chromatin IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of kinesin complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in microtubule IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in microtubule IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitotic spindle IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitotic spindle ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nuclear speck IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nuclear speck ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in spindle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    kinesin-like protein KIF22
    Names
    kinesin family member 22A

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001403623.1 → NP_001390552.1  kinesin-like protein KIF22 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC122863

    2. NM_145588.2 → NP_663563.1  kinesin-like protein KIF22 isoform 1

      See identical proteins and their annotated locations for NP_663563.1

      Status: VALIDATED

      Source sequence(s)
      AC122863
      Consensus CDS
      CCDS21855.1
      UniProtKB/Swiss-Prot
      O35232, Q3V300, Q99LC7
      Related
      ENSMUSP00000032915.7, ENSMUST00000032915.8
      Conserved Domains (3) summary
      smart00129
      Location:38 → 370
      KISc; Kinesin motor, catalytic domain. ATPase
      cd01376
      Location:38 → 361
      KISc_KID_like; Kinesin motor domain, KIF22/Kid-like subgroup
      pfam12836
      Location:591 → 641
      HHH_3; Helix-hairpin-helix motif

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      126626901..126641639 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006507201.2 → XP_006507264.1  kinesin-like protein KIF22 isoform X1

      Conserved Domains (2) summary
      cd01376
      Location:38 → 361
      KISc_KID_like; Kinesin motor domain, KIF22/Kid-like subgroup
      cl39090
      Location:591 → 641
      ComEA; DNA uptake protein ComE and related DNA-binding proteins [Replication, recombination and repair]
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q3V300.2 GenPept UniProtKB/Swiss-Prot:Q3V300

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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