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    Clps colipase, pancreatic [ Mus musculus (house mouse) ]

    Gene ID: 109791, updated on 9-Dec-2024

    Summary

    Official Symbol
    Clpsprovided by MGI
    Official Full Name
    colipase, pancreaticprovided by MGI
    Primary source
    MGI:MGI:88421
    See related
    Ensembl:ENSMUSG00000024225 AllianceGenome:MGI:88421
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    2200003J09Rik
    Summary
    This gene encodes a member of the colipase family of coenzymes that is required for the optimal activity of pancreatic lipase. The encoded protein undergoes proteolytic processing to generate a mature polypeptide that binds to the lipase and prevents inhibition by bile acids. Over half of the mice lacking the encoded protein die within two weeks of birth while the remaining ones exhibit fat malabsorption and altered body weight regulation. Alternative splicing results in multiple transcript variants encoding different isoforms that may undergo similar proteolytic processing. [provided by RefSeq, Nov 2015]
    Expression
    Restricted expression toward stomach adult (RPKM 112946.0) See more
    Orthologs
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    Genomic context

    See Clps in Genome Data Viewer
    Location:
    17 A3.3; 17 14.76 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (28777184..28779740, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (28558210..28560766, complement)

    Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 41506 Neighboring gene armadillo repeat containing 12 Neighboring gene STARR-seq mESC enhancer starr_42217 Neighboring gene colipase-like 2 Neighboring gene microRNA 6969 Neighboring gene STARR-seq mESC enhancer starr_42221 Neighboring gene lipoma HMGIC fusion partner-like 5 Neighboring gene STARR-seq mESC enhancer starr_42224 Neighboring gene serine/arginine-rich protein specific kinase 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (5)  1 citation

    Pathways from PubChem

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables enzyme activator activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables enzyme activator activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables enzyme activator activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables lipase binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in digestion IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in lipid catabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within response to bacterium IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in response to food IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in retinoid metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
     

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001317065.1NP_001303994.1  colipase isoform 2 precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon, compared to variant 1. It encodes isoform 2, which is shorter than isoform 1. This isoform (2) may undergo proteolytic processing similar to isoform 1.
      Source sequence(s)
      AK008815, BM570078, BQ126290
      Consensus CDS
      CCDS84287.1
      UniProtKB/TrEMBL
      B2KF29
      Related
      ENSMUSP00000110433.2, ENSMUST00000114785.3
      Conserved Domains (2) summary
      smart00023
      Location:1972
      COLIPASE; Colipase
      cl24053
      Location:3067
      COLIPASE; Colipase; a stoichiometric cofactor for pancreatic lipase, allowing the enzyme to anchor itself to the water-lipid interface and stabilizing the active enzyme conformation
    2. NM_025469.3NP_079745.1  colipase isoform 1 preproprotein

      See identical proteins and their annotated locations for NP_079745.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AK008815, BM570078, BQ126290
      Consensus CDS
      CCDS28581.1
      UniProtKB/Swiss-Prot
      Q8VHR2, Q8VHR3, Q9CQC2
      UniProtKB/TrEMBL
      Q9D2R7
      Related
      ENSMUSP00000025062.4, ENSMUST00000025062.5
      Conserved Domains (2) summary
      cd00039
      Location:19108
      COLIPASE; Colipase; a stoichiometric cofactor for pancreatic lipase, allowing the enzyme to anchor itself to the water-lipid interface and stabilizing the active enzyme conformation
      smart00023
      Location:19113
      COLIPASE; Colipase

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000083.7 Reference GRCm39 C57BL/6J

      Range
      28777184..28779740 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)