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    Adamts6 ADAM metallopeptidase with thrombospondin type 1 motif 6 [ Mus musculus (house mouse) ]

    Gene ID: 108154, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Adamts6provided by MGI
    Official Full Name
    ADAM metallopeptidase with thrombospondin type 1 motif 6provided by MGI
    Primary source
    MGI:MGI:1347348
    See related
    Ensembl:ENSMUSG00000046169 AllianceGenome:MGI:1347348
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    ADAM-TS6; b2b2029Clo; b2b2182Clo; b2b2228Clo; b2b1879.1Clo; b2b2187.1Clo; A930019D11Rik
    Summary
    Predicted to enable metalloendopeptidase activity. Acts upstream of or within circulatory system development and kidney development. Predicted to be active in extracellular matrix. Is expressed in embryo. Orthologous to human ADAMTS6 (ADAM metallopeptidase with thrombospondin type 1 motif 6). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in limb E14.5 (RPKM 4.5), bladder adult (RPKM 3.5) and 21 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Adamts6 in Genome Data Viewer
    Location:
    13 D1; 13 56.42 cM
    Exon count:
    28
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (104423026..104633203)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (104286518..104496695)

    Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E4090 Neighboring gene peptidylprolyl isomerase domain and WD repeat containing 1 Neighboring gene STARR-positive B cell enhancer ABC_E9887 Neighboring gene CapStarr-seq enhancer MGSCv37_chr13:105076891-105077195 Neighboring gene centromere protein K Neighboring gene STARR-seq mESC enhancer starr_35536 Neighboring gene STARR-seq mESC enhancer starr_35537 Neighboring gene predicted gene 8680 Neighboring gene STARR-seq mESC enhancer starr_35538 Neighboring gene STARR-seq mESC enhancer starr_35540 Neighboring gene predicted gene, 53810 Neighboring gene CWC27 spliceosome-associated protein Neighboring gene STARR-positive B cell enhancer mm9_chr13:105580054-105580355 Neighboring gene CapStarr-seq enhancer MGSCv37_chr13:105607138-105607403 Neighboring gene STARR-seq mESC enhancer starr_35542 Neighboring gene splicing regulatory glutamine/lysine-rich protein 1interacting protein 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Metalloproteinase Adamts16 Is Required for Proper Closure of the Optic Fissure. Cao M, et al. Invest Ophthalmol Vis Sci, 2018 Mar 1. PMID 29625437
    2. TREX tetramer disruption alters RNA processing necessary for corticogenesis in THOC6 Intellectual Disability Syndrome. Werren EA, et al. Nat Commun, 2024 Feb 22. PMID 38388531, Free PMC Article
    3. Murine model indicates 22q11.2 signaling adaptor CRKL is a dosage-sensitive regulator of genitourinary development. Haller M, et al. Proc Natl Acad Sci U S A, 2017 May 9. PMID 28439006, Free PMC Article
    4. Proteolysis of fibrillin-2 microfibrils is essential for normal skeletal development. Mead TJ, et al. Elife, 2022 May 3. PMID 35503090, Free PMC Article
    5. ADAM-TS5, ADAM-TS6, and ADAM-TS7, novel members of a new family of zinc metalloproteases. General features and genomic distribution of the ADAM-TS family. Hurskainen TL, et al. J Biol Chem, 1999 Sep 3. PMID 10464288

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Chemically induced (ENU) (9) 
    • Endonuclease-mediated (1) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables metalloendopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within aorta development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within cardiac septum development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within coronary vasculature development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in extracellular matrix organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within heart development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within kidney development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in proteolysis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in extracellular matrix IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    A disintegrin and metalloproteinase with thrombospondin motifs 6
    Names
    a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 6
    a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 6

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001081020.2 → NP_001074489.1  A disintegrin and metalloproteinase with thrombospondin motifs 6 precursor

      See identical proteins and their annotated locations for NP_001074489.1

      Status: VALIDATED

      Source sequence(s)
      AC154830, AK030315, AK034499, AK044528
      Consensus CDS
      CCDS36773.1
      UniProtKB/TrEMBL
      D3Z1A5
      Related
      ENSMUSP00000064570.7, ENSMUST00000065766.7
      Conserved Domains (6) summary
      smart00209
      Location:561 → 613
      TSP1; Thrombospondin type 1 repeats
      cd04273
      Location:250 → 465
      ZnMc_ADAMTS_like; Zinc-dependent metalloprotease, ADAMTS_like subgroup. ADAMs (A Disintegrin And Metalloprotease) are glycoproteins, which play roles in cell signaling, cell fusion, and cell-cell interactions. This particular subfamily represents domain architectures that ...
      pfam01562
      Location:43 → 191
      Pep_M12B_propep; Reprolysin family propeptide
      pfam05986
      Location:719 → 829
      ADAM_spacer1; ADAM-TS Spacer 1
      pfam08686
      Location:1083 → 1115
      PLAC; PLAC (protease and lacunin) domain
      pfam17771
      Location:480 → 548
      ADAM_CR_2; ADAM cysteine-rich domain

    RNA

    1. NR_136938.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC154830, AC165950, AK030315, AK034499, AK044528
      Related
      ENSMUST00000224784.2

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000079.7 Reference GRCm39 C57BL/6J

      Range
      104423026..104633203
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006517516.2 → XP_006517579.1  A disintegrin and metalloproteinase with thrombospondin motifs 6 isoform X1

      Conserved Domains (6) summary
      smart00209
      Location:182 → 234
      TSP1; Thrombospondin type 1 repeats
      pfam05986
      Location:340 → 450
      ADAM_spacer1; ADAM-TS Spacer 1
      pfam08686
      Location:704 → 736
      PLAC; PLAC (protease and lacunin) domain
      pfam17771
      Location:101 → 169
      ADAM_CR_2; ADAM cysteine-rich domain
      pfam19030
      Location:465 → 520
      TSP1_ADAMTS; Thrombospondin type 1 domain
      cl00064
      Location:1 → 86
      ZnMc; Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which ...

    2. XM_036157826.1 → XP_036013719.1  A disintegrin and metalloproteinase with thrombospondin motifs 6 isoform X3

      Conserved Domains (6) summary
      smart00209
      Location:182 → 234
      TSP1; Thrombospondin type 1 repeats
      pfam05986
      Location:258 → 364
      ADAM_spacer1; ADAM-TS Spacer 1
      pfam08686
      Location:618 → 650
      PLAC; PLAC (protease and lacunin) domain
      pfam17771
      Location:101 → 169
      ADAM_CR_2; ADAM cysteine-rich domain
      pfam19030
      Location:379 → 434
      TSP1_ADAMTS; Thrombospondin type 1 domain
      cl00064
      Location:1 → 86
      ZnMc; Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which ...

    3. XM_030247122.1 → XP_030102982.1  A disintegrin and metalloproteinase with thrombospondin motifs 6 isoform X4

      Conserved Domains (4) summary
      smart00209
      Location:71 → 123
      TSP1; Thrombospondin type 1 repeats
      pfam05986
      Location:229 → 339
      ADAM_spacer1; ADAM-TS Spacer 1
      pfam08686
      Location:593 → 625
      PLAC; PLAC (protease and lacunin) domain
      pfam17771
      Location:10 → 58
      ADAM_CR_2; ADAM cysteine-rich domain

    4. XM_036157825.1 → XP_036013718.1  A disintegrin and metalloproteinase with thrombospondin motifs 6 isoform X2

      Conserved Domains (6) summary
      smart00209
      Location:151 → 203
      TSP1; Thrombospondin type 1 repeats
      pfam05986
      Location:309 → 419
      ADAM_spacer1; ADAM-TS Spacer 1
      pfam08686
      Location:673 → 705
      PLAC; PLAC (protease and lacunin) domain
      pfam17771
      Location:70 → 138
      ADAM_CR_2; ADAM cysteine-rich domain
      pfam19030
      Location:434 → 489
      TSP1_ADAMTS; Thrombospondin type 1 domain
      cl00064
      Location:1 → 55
      ZnMc; Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which ...

    5. XM_011244611.3 → XP_011242913.1  A disintegrin and metalloproteinase with thrombospondin motifs 6 isoform X5

      See identical proteins and their annotated locations for XP_011242913.1

      UniProtKB/TrEMBL
      D3Z1A5
      Conserved Domains (6) summary
      smart00209
      Location:561 → 613
      TSP1; Thrombospondin type 1 repeats
      cd04273
      Location:250 → 465
      ZnMc_ADAMTS_like; Zinc-dependent metalloprotease, ADAMTS_like subgroup. ADAMs (A Disintegrin And Metalloprotease) are glycoproteins, which play roles in cell signaling, cell fusion, and cell-cell interactions. This particular subfamily represents domain architectures that ...
      pfam01562
      Location:43 → 191
      Pep_M12B_propep; Reprolysin family propeptide
      pfam05986
      Location:719 → 829
      ADAM_spacer1; ADAM-TS Spacer 1
      pfam08686
      Location:1083 → 1115
      PLAC; PLAC (protease and lacunin) domain
      pfam17771
      Location:480 → 548
      ADAM_CR_2; ADAM cysteine-rich domain

    6. XM_030247120.1 → XP_030102980.1  A disintegrin and metalloproteinase with thrombospondin motifs 6 isoform X1

      Conserved Domains (6) summary
      smart00209
      Location:182 → 234
      TSP1; Thrombospondin type 1 repeats
      pfam05986
      Location:340 → 450
      ADAM_spacer1; ADAM-TS Spacer 1
      pfam08686
      Location:704 → 736
      PLAC; PLAC (protease and lacunin) domain
      pfam17771
      Location:101 → 169
      ADAM_CR_2; ADAM cysteine-rich domain
      pfam19030
      Location:465 → 520
      TSP1_ADAMTS; Thrombospondin type 1 domain
      cl00064
      Location:1 → 86
      ZnMc; Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which ...

    7. XM_036157824.1 → XP_036013717.1  A disintegrin and metalloproteinase with thrombospondin motifs 6 isoform X1

      Conserved Domains (6) summary
      smart00209
      Location:182 → 234
      TSP1; Thrombospondin type 1 repeats
      pfam05986
      Location:340 → 450
      ADAM_spacer1; ADAM-TS Spacer 1
      pfam08686
      Location:704 → 736
      PLAC; PLAC (protease and lacunin) domain
      pfam17771
      Location:101 → 169
      ADAM_CR_2; ADAM cysteine-rich domain
      pfam19030
      Location:465 → 520
      TSP1_ADAMTS; Thrombospondin type 1 domain
      cl00064
      Location:1 → 86
      ZnMc; Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which ...

    8. XM_030247121.2 → XP_030102981.1  A disintegrin and metalloproteinase with thrombospondin motifs 6 isoform X1

      Conserved Domains (6) summary
      smart00209
      Location:182 → 234
      TSP1; Thrombospondin type 1 repeats
      pfam05986
      Location:340 → 450
      ADAM_spacer1; ADAM-TS Spacer 1
      pfam08686
      Location:704 → 736
      PLAC; PLAC (protease and lacunin) domain
      pfam17771
      Location:101 → 169
      ADAM_CR_2; ADAM cysteine-rich domain
      pfam19030
      Location:465 → 520
      TSP1_ADAMTS; Thrombospondin type 1 domain
      cl00064
      Location:1 → 86
      ZnMc; Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which ...

    9. XM_006517517.3 → XP_006517580.1  A disintegrin and metalloproteinase with thrombospondin motifs 6 isoform X4

      Conserved Domains (4) summary
      smart00209
      Location:71 → 123
      TSP1; Thrombospondin type 1 repeats
      pfam05986
      Location:229 → 339
      ADAM_spacer1; ADAM-TS Spacer 1
      pfam08686
      Location:593 → 625
      PLAC; PLAC (protease and lacunin) domain
      pfam17771
      Location:10 → 58
      ADAM_CR_2; ADAM cysteine-rich domain

    RNA

    1. XR_003950407.1 RNA Sequence

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_175496.2: Suppressed sequence

      Description
      NM_175496.2: This RefSeq was suppressed temporarily based on the calculation that the annotated protein was shorter than a protein or proteins from a putative ortholog.
    Nucleotide Protein Strain
    Heading Accession and Version

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