Brms1 breast cancer metastasis-suppressor 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Brms1provided by MGI
Official Full Name: breast cancer metastasis-suppressor 1provided by MGI
Primary source: MGI:MGI:2388804
See related: Ensembl:ENSMUSG00000080268 AllianceGenome:MGI:2388804
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary: Predicted to enable NF-kappaB binding activity and histone deacetylase binding activity. Predicted to be involved in positive regulation of anoikis; positive regulation of protein deacetylation; and regulation of DNA-templated transcription. Predicted to be located in cytoplasm and nucleus. Predicted to be part of Sin3-type complex. Is expressed in alimentary system; central nervous system; genitourinary system; heart; and respiratory system. Orthologous to human BRMS1 (BRMS1 transcriptional repressor and anoikis regulator). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in testis adult (RPKM 61.2), stomach adult (RPKM 31.2) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 19 A; 19 4.23 cM

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	19	NC_000085.7 (5091391..5099940)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	19	NC_000085.6 (5041363..5049912)

Chromosome 19 - NC_000085.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The Brms1 suppressed pulmonary metastasis and promoted apoptosis of tumor cells located in the lungs but not in the mammary glands.
Title: Ubiquitous Brms1 expression is critical for mammary carcinoma metastasis suppression via promotion of apoptosis.
results show for the first time that BRMS1 contains both nuclear import and export signals enabling its nucleo-cytoplasmic shuttling
Title: Identification of essential sequences for cellular localization in BRMS1 metastasis suppressor.
Comparative sequence analysis in eight inbred strains
Title: Comparative sequence analysis in eight inbred strains of the metastasis modifier QTL candidate gene Brms1.
BRMS1 may participate in transcriptional regulation via interaction with the mSin3.HDAC complex
Title: Breast cancer metastasis suppressor 1 (BRMS1) forms complexes with retinoblastoma-binding protein 1 (RBP1) and the mSin3 histone deacetylase complex and represses transcription.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Targeted (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables NF-kappaB binding	IEA Inferred from Electronic Annotation more info
enables NF-kappaB binding	ISO Inferred from Sequence Orthology more info
enables histone deacetylase binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of DNA-templated transcription	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of NF-kappaB transcription factor activity	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of NF-kappaB transcription factor activity	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of cell migration	NAS Non-traceable Author Statement more info	PubMed
involved_in negative regulation of stem cell population maintenance	NAS Non-traceable Author Statement more info	PubMed
involved_in negative regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of transcription by RNA polymerase II	NAS Non-traceable Author Statement more info	PubMed
involved_in negative regulation of transforming growth factor beta receptor signaling pathway	NAS Non-traceable Author Statement more info	PubMed
involved_in positive regulation of anoikis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of anoikis	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of protein deacetylation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein deacetylation	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of stem cell population maintenance	NAS Non-traceable Author Statement more info	PubMed
involved_in regulation of apoptotic process	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of Sin3-type complex	IBA Inferred from Biological aspect of Ancestor more info
part_of Sin3-type complex	NAS Non-traceable Author Statement more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info
located_in nucleus	NAS Non-traceable Author Statement more info	PubMed

General protein information

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Preferred Names: breast cancer metastasis-suppressor 1 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001374047.1 → NP_001360976.1 breast cancer metastasis-suppressor 1 homolog isoform 1

Status: VALIDATED

Source sequence(s)

AC124502

UniProtKB/Swiss-Prot

Q99N20

UniProtKB/TrEMBL

Q547N0, Q8R5H5

Conserved Domains (1) summary

pfam08598
Location:60 → 178

Sds3; Sds3-like
NM_001374048.1 → NP_001360977.1 breast cancer metastasis-suppressor 1 homolog isoform 2

Status: VALIDATED

Source sequence(s)

AC124502

UniProtKB/TrEMBL

Q8R5H5

Conserved Domains (1) summary

pfam08598
Location:60 → 178

Sds3; Sds3-like
NM_134155.3 → NP_598916.1 breast cancer metastasis-suppressor 1 homolog isoform 1

See identical proteins and their annotated locations for NP_598916.1

Status: VALIDATED

Source sequence(s)

AC124502

Consensus CDS

CCDS50355.1

UniProtKB/Swiss-Prot

Q99N20

UniProtKB/TrEMBL

Q547N0, Q8R5H5

Related

ENSMUSP00000112266.3, ENSMUST00000116567.4

Conserved Domains (1) summary

pfam08598
Location:60 → 178

Sds3; Sds3-like