Gpsm3 G-protein signalling modulator 3 (AGS3-like, C. elegans) [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Gpsm3provided by MGI
Official Full Name: G-protein signalling modulator 3 (AGS3-like, C. elegans)provided by MGI
Primary source: MGI:MGI:2146785
See related: Ensembl:ENSMUSG00000034786 AllianceGenome:MGI:2146785
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: AGS4
Summary: Predicted to enable GTPase regulator activity. Acts upstream of or within positive regulation of cytokine production involved in inflammatory response; positive regulation of inflammatory response; and positive regulation of leukocyte chemotaxis. Located in plasma membrane. Is expressed in genitourinary system; gut; skin; and thymus. Orthologous to human GPSM3 (G protein signaling modulator 3). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in thymus adult (RPKM 69.3), spleen adult (RPKM 37.7) and 10 other tissues See more
Orthologs: human all
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Genomic context

Location:: 17 B1; 17 18.17 cM

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	17	NC_000083.7 (34808780..34810728)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	17	NC_000083.6 (34589806..34591754)

Chromosome 17 - NC_000083.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

findings suggest that GPSM3 acts as a direct negative regulator of NLRP3 function.
Title: G Protein signaling modulator-3 inhibits the inflammasome activity of NLRP3.
GPSM3 is an important regulator of monocyte function involving mechanisms of differentiation, survival, and chemotaxis, and deficiency in GPSM3 expression is protective in acute inflammatory arthritis.
Title: G-protein signaling modulator-3, a gene linked to autoimmune diseases, regulates monocyte function and its deficiency protects from inflammatory arthritis.
the N-terminal region of G18 is a novel G protein-interacting domain that may have distinct regulatory effects within the G(i/o) subfamily
Title: The proline-rich N-terminal domain of G18 exhibits a novel G protein regulatory function.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Gene trapped (1)
Targeted (2)

General gene information

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Markers

Notch4 (e-PCR), detects polymorphism
- UniSTS:265732

M80456 (e-PCR)
- UniSTS:124982

AA960287 (e-PCR)
- UniSTS:160648

Notch4 (e-PCR), detects polymorphism
- UniSTS:144048

Notch4 (e-PCR), detects polymorphism
- UniSTS:496833

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables GTPase regulator activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within positive regulation of cytokine production involved in inflammatory response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of inflammatory response	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within positive regulation of inflammatory response	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of leukocyte chemotaxis	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: G-protein-signaling modulator 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.