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    IBTK inhibitor of Bruton tyrosine kinase [ Mandrillus leucophaeus (drill) ]

    Gene ID: 105528153, updated on 13-Mar-2024

    Summary

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    Gene symbol
    IBTK
    Gene description
    inhibitor of Bruton tyrosine kinase
    See related
    Ensembl:ENSMLEG00000041858
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Mandrillus leucophaeus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Mandrillus
    Orthologs
    human mouse all
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    Genomic context

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    See IBTK in Genome Data Viewer
    Location:
    chromosome: Un
    Exon count:
    29
    Annotation release Status Assembly Chr Location
    100 current Mleu.le_1.0 (GCF_000951045.1) Unplaced Scaffold NW_012107631.1 (988648..1080673, complement)

    NW_012107631.1Genomic Context describing neighboring genes Neighboring gene terminal nucleotidyltransferase 5A Neighboring gene uncharacterized LOC105528152 Neighboring gene single-stranded DNA-binding protein 2 pseudogene Neighboring gene trophoblast glycoprotein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NW_012107631.1 Unplaced Scaffold Reference Mleu.le_1.0

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables protein kinase binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables protein tyrosine kinase inhibitor activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in negative regulation of protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    inhibitor of Bruton tyrosine kinase

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Mandrillus leucophaeus Annotation Release 100 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Mleu.le_1.0

    Genomic

    1. NW_012107631.1 Reference Mleu.le_1.0

      Range
      988648..1080673 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011964764.1 → XP_011820154.1  inhibitor of Bruton tyrosine kinase isoform X1

      UniProtKB/TrEMBL
      A0A2K6A7D3, A0A2K6A7E7
      Related
      ENSMLEP00000035970.1, ENSMLET00000059570.1
      Conserved Domains (8) summary
      smart00225
      Location:768 → 866
      BTB; Broad-Complex, Tramtrack and Bric a brac
      COG5184
      Location:240 → 457
      ATS1; Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]
      cd00204
      Location:25 → 135
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      cd14821
      Location:870 → 930
      SPOP_C_like; BACK-like Domain C-terminal to BTB in speckle-type POZ protein (SPOP) and similar proteins
      pfam00415
      Location:195 → 244
      RCC1; Regulator of chromosome condensation (RCC1) repeat
      pfam00651
      Location:760 → 866
      BTB; BTB/POZ domain
      pfam12796
      Location:25 → 116
      Ank_2; Ankyrin repeats (3 copies)
      sd00045
      Location:51 → 82
      ANK; ANK repeat [structural motif]

    2. XM_011964766.1 → XP_011820156.1  inhibitor of Bruton tyrosine kinase isoform X2

      Conserved Domains (3) summary
      smart00225
      Location:462 → 560
      BTB; Broad-Complex, Tramtrack and Bric a brac
      cd14821
      Location:564 → 624
      SPOP_C_like; BACK-like Domain C-terminal to BTB in speckle-type POZ protein (SPOP) and similar proteins
      pfam00651
      Location:454 → 560
      BTB; BTB/POZ domain
    Nucleotide Protein
    Heading Accession and Version

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