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    Akr1c14 aldo-keto reductase family 1, member C14 [ Mus musculus (house mouse) ]

    Gene ID: 105387, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Akr1c14provided by MGI
    Official Full Name
    aldo-keto reductase family 1, member C14provided by MGI
    Primary source
    MGI:MGI:2145458
    See related
    Ensembl:ENSMUSG00000033715 AllianceGenome:MGI:2145458
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    9030611N15Rik
    Summary
    Enables androsterone dehydrogenase activity. Predicted to be involved in several processes, including androgen biosynthetic process; doxorubicin metabolic process; and prostaglandin metabolic process. Predicted to be located in cytoplasm and nucleus. Predicted to be active in cytosol. Is expressed in gut; liver; metanephros; reproductive system; and respiratory system. Human ortholog(s) of this gene implicated in 46,XY sex reversal 8; B-lymphoblastic leukemia/lymphoma; T-cell acute lymphoblastic leukemia; and leukemia. Orthologous to several human genes including AKR1C1 (aldo-keto reductase family 1 member C1); AKR1C2 (aldo-keto reductase family 1 member C2); and AKR1C3 (aldo-keto reductase family 1 member C3). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in liver adult (RPKM 28.6), liver E18 (RPKM 11.5) and 8 other tissues See more
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    Genomic context

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    See Akr1c14 in Genome Data Viewer
    Location:
    13 A1; 13 2.26 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (4099015..4140569)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (4048991..4090560)

    Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene urocortin 3 Neighboring gene aldo-keto reductase family 1, member C13 pseudogene Neighboring gene STARR-seq mESC enhancer starr_33495 Neighboring gene STARR-seq mESC enhancer starr_33496 Neighboring gene STARR-seq mESC enhancer starr_33497 Neighboring gene STARR-seq mESC enhancer starr_33498 Neighboring gene aldo-keto reductase family 1, member C18 Neighboring gene STARR-seq mESC enhancer starr_33499 Neighboring gene STARR-seq mESC enhancer starr_33500 Neighboring gene solute carrier family 23 (nucleobase transporters), member 2 pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Identification of the oxidative 3alpha-hydroxysteroid dehydrogenase activity of rat Leydig cells as type II retinol dehydrogenase. Hardy DO, et al. Endocrinology, 2000 May. PMID 10803568
    2. Isolation and characterization of a cDNA encoding mouse 3alpha-hydroxysteroid dehydrogenase: an androgen-inactivating enzyme selectively expressed in female tissues. Bellemare V, et al. J Steroid Biochem Mol Biol, 2006 Jan. PMID 16191478
    3. Mouse 3alpha-hydroxysteroid dehydrogenase mRNA: a marker of lung maturity. Provost PR, et al. J Steroid Biochem Mol Biol, 2007 Jan. PMID 17064890
    4. Down-regulation of neurosteroid biosynthesis in corticolimbic circuits mediates social isolation-induced behavior in mice. Agís-Balboa RC, et al. Proc Natl Acad Sci U S A, 2007 Nov 20. PMID 18003893, Free PMC Article
    5. MEF2 and NR2F2 cooperate to regulate Akr1c14 gene expression in mouse MA-10 Leydig cells. Di-Luoffo M, et al. Andrology, 2016 Mar. PMID 26748576

    See all (23) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. results identify a novel cooperation between MEF2 factors and NR2F2 in the expression of the Akr1c14 gene
      Title: MEF2 and NR2F2 cooperate to regulate Akr1c14 gene expression in mouse MA-10 Leydig cells.
    2. In conclusion, our data show that m3alpha-HSD mRNA is a reliable marker of lung maturity in normal pregnancy.
      Title: Mouse 3alpha-hydroxysteroid dehydrogenase mRNA: a marker of lung maturity.
    3. This study evaluates 5alpha-reductase type I and 3alpha-hydroxysteroid dehydrogenase mRNA expression level in mouse brain by using in situ hybridization.
      Title: Characterization of brain neurons that express enzymes mediating neurosteroid biosynthesis.
    4. Using RT-PCR and in situ hybridization, this study compares 5alpha-RI and 3alpha-HSD mRNA brain expression levels in group housed and in socially isolated male mice for 4 weeks.
      Title: Down-regulation of neurosteroid biosynthesis in corticolimbic circuits mediates social isolation-induced behavior in mice.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables 15-hydroxyprostaglandin-D dehydrogenase (NADP+) activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables Delta4-3-oxosteroid 5beta-reductase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables aldo-keto reductase (NADPH) activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables aldose reductase (NADPH) activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables aldose reductase (NADPH) activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables all-trans-retinol dehydrogenase (NAD+) activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables androsterone dehydrogenase (B-specific) activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables androsterone dehydrogenase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables androsterone dehydrogenase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables androsterone dehydrogenase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables bile acid binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables bile acid binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables carboxylic acid binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables chlordecone reductase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables geranylgeranyl reductase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ketoreductase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ketosteroid monooxygenase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ketosteroid monooxygenase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables retinal dehydrogenase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables steroid dehydrogenase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    enables testosterone dehydrogenase [NAD(P)+] activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables trans-1,2-dihydrobenzene-1,2-diol dehydrogenase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in androgen biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    involved_in daunorubicin metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in doxorubicin metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in progesterone metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in prostaglandin metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    3-alpha-hydroxysteroid dehydrogenase
    Names
    3-alpha-hydroxysteroid dehydrogenase type 1
    NP_598833.1
    XP_030102973.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_134072.2 → NP_598833.1  3-alpha-hydroxysteroid dehydrogenase

      See identical proteins and their annotated locations for NP_598833.1

      Status: VALIDATED

      Source sequence(s)
      AC122840
      Consensus CDS
      CCDS26218.1
      UniProtKB/TrEMBL
      Q91WT7
      Related
      ENSMUSP00000045394.7, ENSMUST00000041768.7
      Conserved Domains (1) summary
      cd19108
      Location:6 → 308
      AKR_AKR1C1-35; AKR1C family of aldo-keto reductase (AKR)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000079.7 Reference GRCm39 C57BL/6J

      Range
      4099015..4140569
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030247113.2 → XP_030102973.1  3-alpha-hydroxysteroid dehydrogenase isoform X1

      UniProtKB/TrEMBL
      Q91WT7
      Related
      ENSMUSP00000112664.3, ENSMUST00000118717.10
      Conserved Domains (1) summary
      cd19108
      Location:6 → 308
      AKR_AKR1C1-35; AKR1C family of aldo-keto reductase (AKR)
    Nucleotide Protein Strain
    Heading Accession and Version

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