Dusp22 dual specificity phosphatase 22 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Dusp22provided by MGI
Official Full Name: dual specificity phosphatase 22provided by MGI
Primary source: MGI:MGI:1915926
See related: Ensembl:ENSMUSG00000069255 AllianceGenome:MGI:1915926
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: JKAP; JSP1; MKPX; LMW-DSP2
Summary: Enables protein tyrosine kinase binding activity and protein tyrosine phosphatase activity. Acts upstream of or within several processes, including negative regulation of T cell mediated immunity; regulation of signal transduction; and transforming growth factor beta receptor signaling pathway. Predicted to be located in cytoplasm and leading edge of lamellipodium. Predicted to be part of filamentous actin. Predicted to be active in cytosol and plasma membrane. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; nose; and somite. Orthologous to human DUSP22 (dual specificity phosphatase 22). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in bladder adult (RPKM 7.7), mammary gland adult (RPKM 7.2) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 13 A3.2; 13 13.26 cM

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	13	NC_000079.7 (30844042..30895215)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	13	NC_000079.6 (30660059..30711232)

Chromosome 13 - NC_000079.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

JNK Pathway-Associated Phosphatase Deficiency Facilitates Atherosclerotic Progression by Inducing T-Helper 1 and 17 Polarization and Inflammation in an ERK- and NF-kappaB Pathway-Dependent Manner.
Title: JNK Pathway-Associated Phosphatase Deficiency Facilitates Atherosclerotic Progression by Inducing T-Helper 1 and 17 Polarization and Inflammation in an ERK- and NF-κB Pathway-Dependent Manner.
Dual-specificity phosphatases 22-deficient T cells contribute to the pathogenesis of ankylosing spondylitis.
Title: Dual-specificity phosphatases 22-deficient T cells contribute to the pathogenesis of ankylosing spondylitis.
Hepatocyte phosphatase DUSP22 mitigates NASH-HCC progression by targeting FAK.
Title: Hepatocyte phosphatase DUSP22 mitigates NASH-HCC progression by targeting FAK.
Dusp22 expression in the adult mouse tissues and organs
Title: Expression analyses of Dusp22 (Dual-specificity phosphatase 22) in mouse tissues.
DSP2 acts as a negative regulator of the IL-6/LIF/STAT3-mediated signaling pathway.
Title: Regulation of STAT3-mediated signaling by LMW-DSP2.
cloning and characterization of JKAP, a positive regulator of the JNK pathway
Title: The dual specificity JKAP specifically activates the c-Jun N-terminal kinase pathway.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Targeted (1) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AW212235 (e-PCR)
- UniSTS:180511

MKPX (e-PCR)
- UniSTS:266142

Dusp22 (e-PCR), detects polymorphism
- UniSTS:506867

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables MAP kinase serine/threonine phosphatase activity	IEA Inferred from Electronic Annotation more info
enables RNA polymerase II CTD heptapeptide repeat S2 phosphatase activity	IEA Inferred from Electronic Annotation more info
enables RNA polymerase II CTD heptapeptide repeat S5 phosphatase activity	IEA Inferred from Electronic Annotation more info
enables RNA polymerase II CTD heptapeptide repeat S7 phosphatase activity	IEA Inferred from Electronic Annotation more info
enables RNA polymerase II CTD heptapeptide repeat T4 phosphatase activity	IEA Inferred from Electronic Annotation more info
enables RNA polymerase II CTD heptapeptide repeat Y1 phosphatase activity	IEA Inferred from Electronic Annotation more info
enables calmodulin-dependent protein phosphatase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AXS140 phosphatase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AXY142 phosphatase activity	IEA Inferred from Electronic Annotation more info
enables myosin phosphatase activity	IEA Inferred from Electronic Annotation more info
enables non-membrane spanning protein tyrosine phosphatase activity	IEA Inferred from Electronic Annotation more info
enables non-membrane spanning protein tyrosine phosphatase activity	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein tyrosine kinase binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein tyrosine kinase binding	ISO Inferred from Sequence Orthology more info
enables protein tyrosine kinase inhibitor activity	IEA Inferred from Electronic Annotation more info
enables protein tyrosine phosphatase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein tyrosine phosphatase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein tyrosine phosphatase activity	ISO Inferred from Sequence Orthology more info
enables protein tyrosine phosphatase activity, metal-dependent	IEA Inferred from Electronic Annotation more info
enables protein tyrosine/serine/threonine phosphatase activity	ISO Inferred from Sequence Orthology more info	PubMed

Process	Evidence Code	Pubs
involved_in cellular response to epidermal growth factor stimulus	IEA Inferred from Electronic Annotation more info
involved_in cellular response to epidermal growth factor stimulus	ISO Inferred from Sequence Orthology more info
involved_in chromatin remodeling	IEA Inferred from Electronic Annotation more info
involved_in immune system process	IEA Inferred from Electronic Annotation more info
involved_in intracellular signal transduction	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of T cell activation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of T cell mediated immunity	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of T cell receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of T cell receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cell migration	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of cell migration	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of focal adhesion assembly	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of focal adhesion assembly	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of non-membrane spanning protein tyrosine kinase activity	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in peptidyl-tyrosine dephosphorylation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of JNK cascade	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within positive regulation of JNK cascade	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within regulation of cell population proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in transforming growth factor beta receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within transforming growth factor beta receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
part_of filamentous actin	IEA Inferred from Electronic Annotation more info
part_of filamentous actin	ISO Inferred from Sequence Orthology more info
located_in leading edge of lamellipodium	IEA Inferred from Electronic Annotation more info
located_in leading edge of lamellipodium	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: dual specificity protein phosphatase 22

Names: JNK pathway associated phosphatase; low molecular weight dual specificity phosphatase 2

NP_001033044.1

EC 3.1.3.16

EC 3.1.3.48

NP_598829.1

EC 3.1.3.16

EC 3.1.3.48

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001037955.4 → NP_001033044.1 dual specificity protein phosphatase 22 isoform a

See identical proteins and their annotated locations for NP_001033044.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a).

Source sequence(s)

AA137950, AK003947, AK148708, AK149363, BY477408, CX236611

Consensus CDS

CCDS26418.1

UniProtKB/Swiss-Prot

Q99N11

Related

ENSMUSP00000093603.6, ENSMUST00000095914.7

Conserved Domains (1) summary

cd00127
Location:4 → 139

DSPc; Dual specificity phosphatases (DSP); Ser/Thr and Tyr protein phosphatases. Structurally similar to tyrosine-specific phosphatases but with a shallower active site cleft and a distinctive active site signature motif, HCxxGxxR. Characterized as VHR- or ...
NM_134068.4 → NP_598829.1 dual specificity protein phosphatase 22 isoform b

See identical proteins and their annotated locations for NP_598829.1

Status: VALIDATED

Source sequence(s)

AA137950, AK003947, AK148708, BY477408, CX236611

Consensus CDS

CCDS26417.1

UniProtKB/Swiss-Prot

Q5SQN9, Q5SQP0, Q99N11

Related

ENSMUSP00000089260.7, ENSMUST00000091672.13

Conserved Domains (1) summary

cd00127
Location:4 → 139

DSPc; Dual specificity phosphatases (DSP); Ser/Thr and Tyr protein phosphatases. Structurally similar to tyrosine-specific phosphatases but with a shallower active site cleft and a distinctive active site signature motif, HCxxGxxR. Characterized as VHR- or ...