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    Fyn FYN proto-oncogene, Src family tyrosine kinase [ Fukomys damarensis (Damara mole-rat) ]

    Gene ID: 104866654, updated on 11-Apr-2024

    Summary

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    Gene symbol
    Fyn
    Gene description
    FYN proto-oncogene, Src family tyrosine kinase
    Locus tag
    H920_08095
    See related
    Ensembl:ENSFDAG00000018973
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Fukomys damarensis
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Bathyergidae; Fukomys
    Orthologs
    human mouse all
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    Genomic context

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    See Fyn in Genome Data Viewer
    Location:
    chromosome: Un
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    102 current DMR_v1.0_HiC (GCF_012274545.1) Unplaced Scaffold NW_022900926.1 (69840950..70023583, complement)
    101 previous assembly DMR_v1.0 (GCF_000743615.1) Unplaced Scaffold NW_011045015.1 (1021270..1203889, complement)

    NW_022900926.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC104866653 Neighboring gene TRAF3 interacting protein 2 Neighboring gene uncharacterized LOC117285993 Neighboring gene U2 spliceosomal RNA Neighboring gene uncharacterized LOC117285994 Neighboring gene lys-63-specific deubiquitinase BRCC36-like

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    2. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables non-membrane spanning protein tyrosine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables signaling receptor binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in T cell receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in cell differentiation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in cell surface receptor protein tyrosine kinase signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in innate immune response IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in extrinsic component of cytoplasmic side of plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    tyrosine-protein kinase Fyn
    Names
    Tyrosine-protein kinase Fyn

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Fukomys damarensis Annotation Release 102 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference DMR_v1.0_HiC Primary Assembly

    Genomic

    1. NW_022900926.1 Reference DMR_v1.0_HiC Primary Assembly

      Range
      69840950..70023583 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_010630841.2 → XP_010629143.1  tyrosine-protein kinase Fyn isoform X2

      See identical proteins and their annotated locations for XP_010629143.1

      UniProtKB/TrEMBL
      A0A091DJ27
      Related
      ENSFDAP00000011394.1
      Conserved Domains (3) summary
      cd10368
      Location:145 → 245
      SH2_Src_Fyn; Src homology 2 (SH2) domain found in Fyn
      cd12006
      Location:85 → 140
      SH3_Fyn_Yrk; Src homology 3 domain of Fyn and Yrk Protein Tyrosine Kinases
      cd05070
      Location:258 → 531
      PTKc_Fyn; Catalytic domain of the Protein Tyrosine Kinase, Fyn

    2. XM_010630839.2 → XP_010629141.1  tyrosine-protein kinase Fyn isoform X1

      See identical proteins and their annotated locations for XP_010629141.1

      Related
      ENSFDAP00000011404.1
      Conserved Domains (3) summary
      cd10418
      Location:145 → 245
      SH2_Src_Fyn_isoform_a_like; Src homology 2 (SH2) domain found in Fyn isoform a like proteins
      cd12006
      Location:85 → 140
      SH3_Fyn_Yrk; Src homology 3 domain of Fyn and Yrk Protein Tyrosine Kinases
      cd05070
      Location:261 → 534
      PTKc_Fyn; Catalytic domain of the Protein Tyrosine Kinase, Fyn

    3. XM_010630840.3 → XP_010629142.1  tyrosine-protein kinase Fyn isoform X1

      See identical proteins and their annotated locations for XP_010629142.1

      Related
      ENSFDAP00000011387.1
      Conserved Domains (3) summary
      cd10418
      Location:145 → 245
      SH2_Src_Fyn_isoform_a_like; Src homology 2 (SH2) domain found in Fyn isoform a like proteins
      cd12006
      Location:85 → 140
      SH3_Fyn_Yrk; Src homology 3 domain of Fyn and Yrk Protein Tyrosine Kinases
      cd05070
      Location:261 → 534
      PTKc_Fyn; Catalytic domain of the Protein Tyrosine Kinase, Fyn
    Nucleotide Protein
    Heading Accession and Version

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