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    syt8 synaptotagmin VIII [ Danio rerio (zebrafish) ]

    Gene ID: 103909874, updated on 9-Dec-2024

    Summary

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    Official Symbol
    syt8provided by ZNC
    Official Full Name
    synaptotagmin VIIIprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-060303-4
    See related
    AllianceGenome:ZFIN:ZDB-GENE-060303-4
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Summary
    Predicted to be located in membrane. Orthologous to human SYT8 (synaptotagmin 8). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See syt8 in Genome Data Viewer
    Location:
    chromosome: 25
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 25 NC_007136.7 (31175696..31195580)
    105 previous assembly GRCz10 (GCF_000002035.5) 25 NC_007136.6 (31109186..31124211)

    Chromosome 25 - NC_007136.7Genomic Context describing neighboring genes Neighboring gene ras association domain-containing protein 8 Neighboring gene cytosolic 5'-nucleotidase 1A Neighboring gene uncharacterized LOC101884923 Neighboring gene troponin I type 2a (skeletal, fast), tandem duplicate 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Cytoplasmic pool of U1 spliceosome protein SNRNP70 shapes the axonal transcriptome and regulates motor connectivity. Nikolaou N, et al. Curr Biol, 2022 Dec 5. PMID 36384140
    2. Expression and distribution of synaptotagmin family members in the zebrafish retina. Henry D, et al. J Comp Neurol, 2022 Mar. PMID 34468021, Free PMC Article
    3. Evolutionary genomics of plant genes encoding N-terminal-TM-C2 domain proteins and the similar FAM62 genes and synaptotagmin genes of metazoans. Craxton M. BMC Genomics, 2007 Jul 31. PMID 17672888, Free PMC Article
    4. Functional analysis reveals no transcriptional role for the glucocorticoid receptor β-isoform in zebrafish. Chatzopoulou A, et al. Mol Cell Endocrinol, 2017 May 15. PMID 28242321
    5. A manual collection of Syt, Esyt, Rph3a, Rph3al, Doc2, and Dblc2 genes from 46 metazoan genomes--an open access resource for neuroscience and evolutionary biology. Craxton M. BMC Genomics, 2010 Jan 15. PMID 20078875, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by ZFIN

    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    synaptotagmin VIII
    Names
    synaptotagmin-1-like

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001365289.1 → NP_001352218.1  synaptotagmin VIII isoform 1

      Status: VALIDATED

      Source sequence(s)
      FQ976913
      UniProtKB/TrEMBL
      A0A8M9PND4
      Conserved Domains (2) summary
      cd08385
      Location:106 → 229
      C2A_Synaptotagmin-1-5-6-9-10; C2A domain first repeat present in Synaptotagmins 1, 5, 6, 9, and 10
      cd08402
      Location:238 → 372
      C2B_Synaptotagmin-1; C2 domain second repeat present in Synaptotagmin 1

    2. NM_001365290.1 → NP_001352219.1  synaptotagmin VIII isoform 2

      Status: VALIDATED

      Source sequence(s)
      FQ976913
      UniProtKB/TrEMBL
      A0A8M9PVL9
      Conserved Domains (2) summary
      cd08402
      Location:206 → 340
      C2B_Synaptotagmin-1; C2 domain second repeat present in Synaptotagmin 1
      cl14603
      Location:87 → 197
      C2; C2 domain

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007136.7 Reference GRCz11 Primary Assembly

      Range
      31175696..31195580
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_068217304.1 → XP_068073405.1  synaptotagmin VIII isoform X1

      UniProtKB/TrEMBL
      A0A8M9PND4

    2. XM_021470717.2 → XP_021326392.1  synaptotagmin VIII isoform X2

      UniProtKB/TrEMBL
      A0A8M9P6W9
      Conserved Domains (2) summary
      cd08385
      Location:73 → 196
      C2A_Synaptotagmin-1-5-6-9-10; C2A domain first repeat present in Synaptotagmins 1, 5, 6, 9, and 10
      cd08402
      Location:205 → 339
      C2B_Synaptotagmin-1; C2 domain second repeat present in Synaptotagmin 1
    Nucleotide Protein Strain
    Heading Accession and Version

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