U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination
    • Showing Current items.

    map4k4 mitogen-activated protein kinase kinase kinase kinase 4 [ Danio rerio (zebrafish) ]

    Gene ID: 103908625, updated on 4-Jan-2025

    Summary

    Go to the top of the page Help
    Official Symbol
    map4k4provided by ZNC
    Official Full Name
    mitogen-activated protein kinase kinase kinase kinase 4provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-6722
    See related
    Ensembl:ENSDARG00000098670 AllianceGenome:ZFIN:ZDB-GENE-030131-6722
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    fa03e11; wu:fa03e11; si:zfos-433a6.1
    Summary
    Predicted to enable ATP binding activity and protein serine/threonine kinase activity. Predicted to act upstream of or within protein phosphorylation. Human ortholog(s) of this gene implicated in hepatocellular carcinoma and lung adenocarcinoma. Orthologous to human MAP4K4 (mitogen-activated protein kinase kinase kinase kinase 4). [provided by Alliance of Genome Resources, Jan 2025]
    Orthologs
    human mouse all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See map4k4 in Genome Data Viewer
    Location:
    chromosome: 9
    Exon count:
    23
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 9 NC_007120.7 (22095..38385, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 9 NC_007120.6 (18407..33995, complement)

    Chromosome 9 - NC_007120.7Genomic Context describing neighboring genes Neighboring gene ribosomal RNA processing protein 1 homolog A Neighboring gene interleukin-1 receptor type 2 Neighboring gene hyccin PI4KA lipid kinase complex subunit 2 Neighboring gene interleukin 10 receptor, beta

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Expression

    Go to the top of the page Help
    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Abrogation of MAP4K4 protein function causes congenital anomalies in humans and zebrafish. Patterson V, et al. Sci Adv, 2023 Apr 28. PMID 37126546, Free PMC Article
    2. Coordinated cell-shape changes control epithelial movement in zebrafish and Drosophila. Köppen M, et al. Development, 2006 Jul. PMID 16794032
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article
    5. Gene evolution and gene expression after whole genome duplication in fish: the PhyloFish database. Pasquier J, et al. BMC Genomics, 2016 May 18. PMID 27189481, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Abrogation of MAP4K4 protein function causes congenital anomalies in humans and zebrafish.
      Title: Abrogation of MAP4K4 protein function causes congenital anomalies in humans and zebrafish.
    Submit: New GeneRIF Correction

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    mitogen-activated protein kinase kinase kinase kinase 4
    Names
    msn2
    XP_021334466.1
    XP_021334469.1
    XP_068079619.1

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007120.7 Reference GRCz11 Primary Assembly

      Range
      22095..38385 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_021478794.2 → XP_021334469.1  mitogen-activated protein kinase kinase kinase kinase 4 isoform X2

      UniProtKB/TrEMBL
      A0A8M9QB07
      Conserved Domains (2) summary
      smart00036
      Location:612 → 910
      CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
      cl21453
      Location:1 → 209
      PKc_like; Protein Kinases, catalytic domain

    2. XM_068223518.1 → XP_068079619.1  mitogen-activated protein kinase kinase kinase kinase 4 isoform X1

      UniProtKB/TrEMBL
      A0A8M9QFN8

    3. XM_021478791.2 → XP_021334466.1  mitogen-activated protein kinase kinase kinase kinase 4 isoform X1

      UniProtKB/TrEMBL
      A0A8M9QFN8
      Related
      ENSDARP00000130351.1, ENSDART00000171335.2
      Conserved Domains (2) summary
      smart00036
      Location:688 → 986
      CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
      cl21453
      Location:1 → 209
      PKc_like; Protein Kinases, catalytic domain
    Nucleotide Protein
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials