Mgat4b mannoside acetylglucosaminyltransferase 4, isoenzyme B [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Mgat4bprovided by MGI
Official Full Name: mannoside acetylglucosaminyltransferase 4, isoenzyme Bprovided by MGI
Primary source: MGI:MGI:2143974
See related: Ensembl:ENSMUSG00000036620 AllianceGenome:MGI:2143974
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: GnTIVb
Summary: Enables acetylglucosaminyltransferase activity. Acts upstream of or within protein N-linked glycosylation. Predicted to be located in Golgi membrane. Predicted to be active in Golgi stack; endoplasmic reticulum; and endoplasmic reticulum-Golgi intermediate compartment. Is expressed in several structures, including adrenal gland; nervous system; nose; respiratory system; and urinary system. Orthologous to human MGAT4B (alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase B). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in colon adult (RPKM 90.9), adrenal adult (RPKM 83.9) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 11 B1.3; 11 30.37 cM

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	11	NC_000077.7 (50116162..50125930)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	11	NC_000077.6 (50225335..50235103)

Chromosome 11 - NC_000077.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Targeted (2) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables acetylglucosaminyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables acetylglucosaminyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity	ISO Inferred from Sequence Orthology more info
enables alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity	ISS Inferred from Sequence or Structural Similarity more info
enables glycosyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables metal ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in protein N-linked glycosylation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within protein N-linked glycosylation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in protein glycosylation	ISO Inferred from Sequence Orthology more info
involved_in protein glycosylation	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in Golgi membrane	IEA Inferred from Electronic Annotation more info
is_active_in Golgi stack	IBA Inferred from Biological aspect of Ancestor more info
is_active_in endoplasmic reticulum	IBA Inferred from Biological aspect of Ancestor more info
is_active_in endoplasmic reticulum-Golgi intermediate compartment	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase B

Names: GlcNAc-T IVb; N-acetylglucosaminyltransferase IVb; N-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase IVb; UDP-N-acetylglucosamine: alpha-1,3-D-mannoside beta-1,4-N-acetylglucosaminyltransferase IVb; gnT-IVb; mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isoenzyme B

NP_666038.3

EC 2.4.1.145

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_145926.3 → NP_666038.3 alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase B

See identical proteins and their annotated locations for NP_666038.3

Status: VALIDATED

Source sequence(s)

AL627187, BY729920, CX205743, CX206051, W66623

Consensus CDS

CCDS24630.1

UniProtKB/Swiss-Prot

Q3U2D9, Q812F8, Q812F9, Q8R0L4

Related

ENSMUSP00000043346.8, ENSMUST00000041725.14

Conserved Domains (2) summary

pfam04666
Location:110 → 387

Glyco_transf_54; N-Acetylglucosaminyltransferase-IV (GnT-IV) conserved region

cd21105
Location:294 → 314

PGAP4-like; putative TM2 helix [structural motif]