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    JAK2 Janus kinase 2 [ Physeter macrocephalus (sperm whale) ]

    Gene ID: 102978811, updated on 30-Nov-2024

    Summary

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    Gene symbol
    JAK2
    Gene description
    Janus kinase 2
    See related
    Ensembl:ENSPCTG00005005720
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Physeter macrocephalus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Odontoceti; Physeteridae; Physeter
    Orthologs
    human mouse all
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    Genomic context

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    See JAK2 in Genome Data Viewer
    Location:
    chromosome: 9
    Exon count:
    28
    Annotation release Status Assembly Chr Location
    RS_2023_04 current ASM283717v5 (GCF_002837175.3) 9 NC_041222.1 (47944767..48113040)
    102 previous assembly ASM283717v2 (GCF_002837175.2) 9 NC_041222.1 (47944992..48100077)

    Chromosome 9 - NC_041222.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC114486822 Neighboring gene adenylate kinase 3 Neighboring gene RNA terminal phosphate cyclase like 1 Neighboring gene transfer RNA valine (anticodon CAC) Neighboring gene insulin like 6 Neighboring gene relaxin 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    2. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables cytokine receptor binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables histone binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables non-membrane spanning protein tyrosine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cell differentiation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in cell surface receptor signaling pathway via JAK-STAT IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in cytokine-mediated signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in hemopoiesis IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in intracellular signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in peptidyl-tyrosine phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    tyrosine-protein kinase JAK2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_002837175.3-RS_2023_04

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ASM283717v5 Primary Assembly

    Genomic

    1. NC_041222.1 Reference ASM283717v5 Primary Assembly

      Range
      47944767..48113040
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_024126771.3 → XP_023982539.1  tyrosine-protein kinase JAK2 isoform X2

      UniProtKB/TrEMBL
      A0A2Y9SYZ0
      Conserved Domains (5) summary
      cd10379
      Location:386 → 482
      SH2_Jak2; Src homology 2 (SH2) domain in the Janus kinase 2 (Jak2) proteins
      smart00295
      Location:38 → 270
      B41; Band 4.1 homologues
      cd13333
      Location:266 → 386
      FERM_C_JAK2; FERM domain C-lobe of Janus kinase (JAK) 2
      cd05078
      Location:545 → 806
      PTK_Jak2_rpt1; Pseudokinase (repeat 1) domain of the Protein Tyrosine Kinase, Janus kinase 2
      cd14205
      Location:844 → 1127
      PTKc_Jak2_rpt2; Catalytic (repeat 2) domain of the Protein Tyrosine Kinase, Janus kinase 2

    2. XM_024126773.3 → XP_023982541.1  tyrosine-protein kinase JAK2 isoform X2

      UniProtKB/TrEMBL
      A0A2Y9SYZ0
      Conserved Domains (5) summary
      cd10379
      Location:386 → 482
      SH2_Jak2; Src homology 2 (SH2) domain in the Janus kinase 2 (Jak2) proteins
      smart00295
      Location:38 → 270
      B41; Band 4.1 homologues
      cd13333
      Location:266 → 386
      FERM_C_JAK2; FERM domain C-lobe of Janus kinase (JAK) 2
      cd05078
      Location:545 → 806
      PTK_Jak2_rpt1; Pseudokinase (repeat 1) domain of the Protein Tyrosine Kinase, Janus kinase 2
      cd14205
      Location:844 → 1127
      PTKc_Jak2_rpt2; Catalytic (repeat 2) domain of the Protein Tyrosine Kinase, Janus kinase 2

    3. XM_055087198.1 → XP_054943173.1  tyrosine-protein kinase JAK2 isoform X1

      UniProtKB/TrEMBL
      A0A9W2WVI8

    4. XM_055087199.1 → XP_054943174.1  tyrosine-protein kinase JAK2 isoform X2

      UniProtKB/TrEMBL
      A0A2Y9SYZ0

    5. XM_055087200.1 → XP_054943175.1  tyrosine-protein kinase JAK2 isoform X2

      UniProtKB/TrEMBL
      A0A2Y9SYZ0
      Related
      ENSPCTP00005008113.1, ENSPCTT00005008936.1

    6. XM_028493954.2 → XP_028349755.1  tyrosine-protein kinase JAK2 isoform X3

      UniProtKB/TrEMBL
      A0A455BLA3
      Conserved Domains (4) summary
      cd10379
      Location:142 → 238
      SH2_Jak2; Src homology 2 (SH2) domain in the Janus kinase 2 (Jak2) proteins
      cd13333
      Location:22 → 142
      FERM_C_JAK2; FERM domain C-lobe of Janus kinase (JAK) 2
      cd05078
      Location:301 → 562
      PTK_Jak2_rpt1; Pseudokinase (repeat 1) domain of the Protein Tyrosine Kinase, Janus kinase 2
      cd14205
      Location:600 → 883
      PTKc_Jak2_rpt2; Catalytic (repeat 2) domain of the Protein Tyrosine Kinase, Janus kinase 2
    Nucleotide Protein
    Heading Accession and Version

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