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    RANGAP2 Ran GTPase-activating protein 2 [ Solanum tuberosum (potato) ]

    Gene ID: 102577808, updated on 2-Nov-2023

    Summary

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    Gene symbol
    RANGAP2
    Gene description
    Ran GTPase-activating protein 2
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Solanum tuberosum
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; asterids; lamiids; Solanales; Solanaceae; Solanoideae; Solaneae; Solanum
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    Genomic context

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    See RANGAP2 in Genome Data Viewer
    Location:
    chromosome: Un
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    101 current SolTub_3.0 (GCF_000226075.1) Unplaced Scaffold NW_006239030.1 (1213915..1216916)

    NW_006239030.1Genomic Context describing neighboring genes Neighboring gene CTP synthase-like Neighboring gene uncharacterized LOC102579218 Neighboring gene uncharacterized LOC107060921 Neighboring gene probable ATP-dependent DNA helicase CHR12 Neighboring gene peroxisome biogenesis protein 7-like

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NW_006239030.1 Unplaced Scaffold Reference SolTub_3.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Structural basis for the interaction between the potato virus X resistance protein (Rx) and its cofactor Ran GTPase-activating protein 2 (RanGAP2). Hao W, et al. J Biol Chem, 2013 Dec 13. PMID 24194517, Free PMC Article
    2. Evolution and variability of Solanum RanGAP2, a cofactor in the incompatible interaction between the resistance protein GPA2 and the Globodera pallida effector Gp-RBP-1. Carpentier J, et al. BMC Evol Biol, 2013 Apr 19. PMID 23601377, Free PMC Article
    3. Divergent evolution of potato immune receptor CC domain interactions with the Ran GTPase-activating protein 2. Sobhanian S, et al. Plant Signal Behav, 2014. PMID 25763710, Free PMC Article
    4. A RanGAP protein physically interacts with the NB-LRR protein Rx, and is required for Rx-mediated viral resistance. Sacco MA, et al. Plant J, 2007 Oct. PMID 17655649
    5. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. findings substantiate the importance of RanGAP2 as a common CC-interacting protein of multiple immune receptors requiring further study to define their roles in pathogen perception
      Title: Divergent evolution of potato immune receptor CC domain interactions with the Ran GTPase-activating protein 2.
    2. RanGap2 genetic variability does not influence the specificity of GPA2 recognition but is able to modulate this activity by enhancing the defence response.
      Title: Evolution and variability of Solanum RanGAP2, a cofactor in the incompatible interaction between the resistance protein GPA2 and the Globodera pallida effector Gp-RBP-1.
    3. molecular mechanism underlying the interaction of Rx with RanGAP2
      Title: Structural basis for the interaction between the potato virus X resistance protein (Rx) and its cofactor Ran GTPase-activating protein 2 (RanGAP2).
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables GTPase activator activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables protein binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Ran GTPase-activating protein 2; ran GTPase-activating protein 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001288250.1 → NP_001275179.1  Ran GTPase-activating protein 2

      See identical proteins and their annotated locations for NP_001275179.1

      Status: PROVISIONAL

      Source sequence(s)
      AM411448
      UniProtKB/TrEMBL
      A7M8K2, I7ILS8
      Conserved Domains (3) summary
      cd00116
      Location:183 → 449
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      sd00033
      Location:216 → 243
      LRR_RI; leucine-rich repeat [structural motif]
      pfam13943
      Location:15 → 109
      WPP; WPP domain

    RefSeqs of Annotated Genomes: Solanum tuberosum Annotation Release 101 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference SolTub_3.0 Primary Assembly

    Genomic

    1. NW_006239030.1 Reference SolTub_3.0 Primary Assembly

      Range
      1213915..1216916
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006349150.2 → XP_006349212.1  ran GTPase-activating protein 2 isoform X1

      See identical proteins and their annotated locations for XP_006349212.1

      UniProtKB/TrEMBL
      I7ICB4, I7ILN7, I7JNX9, M1AI54
      Conserved Domains (4) summary
      COG5238
      Location:125 → 532
      RNA1; Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Signal transduction mechanisms, RNA processing and modification]
      cd00116
      Location:131 → 443
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      sd00033
      Location:183 → 215
      LRR_RI; leucine-rich repeat [structural motif]
      pfam13943
      Location:15 → 109
      WPP; WPP domain

    2. XM_006349151.2 → XP_006349213.1  ran GTPase-activating protein 2 isoform X1

      See identical proteins and their annotated locations for XP_006349213.1

      UniProtKB/TrEMBL
      I7ICB4, I7ILN7, I7JNX9, M1AI54
      Conserved Domains (4) summary
      COG5238
      Location:125 → 532
      RNA1; Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Signal transduction mechanisms, RNA processing and modification]
      cd00116
      Location:131 → 443
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      sd00033
      Location:183 → 215
      LRR_RI; leucine-rich repeat [structural motif]
      pfam13943
      Location:15 → 109
      WPP; WPP domain
    Nucleotide Protein
    Heading Accession and Version

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