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    BRAF B-Raf proto-oncogene, serine/threonine kinase [ Otolemur garnettii (small-eared galago) ]

    Gene ID: 100955336, updated on 8-Mar-2024

    Summary

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    Gene symbol
    BRAF
    Gene description
    B-Raf proto-oncogene, serine/threonine kinase
    See related
    Ensembl:ENSOGAG00000009646
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Otolemur garnettii
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Strepsirrhini; Lorisiformes; Galagidae; Otolemur
    Orthologs
    human mouse all
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    Genomic context

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    See BRAF in Genome Data Viewer
    Location:
    chromosome: Un
    Exon count:
    23
    Annotation release Status Assembly Chr Location
    102 current OtoGar3 (GCF_000181295.1) Unplaced Scaffold NW_003852444.1 (3983128..4165221)

    NW_003852444.1Genomic Context describing neighboring genes Neighboring gene mitochondrial ribosomal protein S33 Neighboring gene transformer-2 protein homolog alpha pseudogene Neighboring gene small nucleolar RNA U3 Neighboring gene NADH:ubiquinone oxidoreductase subunit B2 Neighboring gene aarF domain containing kinase 2

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NW_003852444 Unplaced Scaffold Reference OtoGar3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    2. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    serine/threonine-protein kinase B-raf
    Names
    v-raf murine sarcoma viral oncogene homolog B1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Otolemur garnettii Annotation Release 102 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference OtoGar3

    Genomic

    1. NW_003852444.1 Reference OtoGar3

      Range
      3983128..4165221
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_023514190.1 → XP_023369958.1  serine/threonine-protein kinase B-raf isoform X1

      UniProtKB/TrEMBL
      H0X101
      Conserved Domains (3) summary
      cd01816
      Location:130 → 201
      Raf_RBD; Ubiquitin domain of Raf serine/threonine kinases
      cd14062
      Location:437 → 689
      STKc_Raf; Catalytic domain of the Serine/Threonine Kinases, Raf (Rapidly Accelerated Fibrosarcoma) kinases
      pfam00130
      Location:209 → 254
      C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)

    2. XM_023514193.1 → XP_023369961.1  serine/threonine-protein kinase B-raf isoform X4

      UniProtKB/TrEMBL
      H0X101
      Related
      ENSOGAP00000008634.2, ENSOGAT00000009653.2
      Conserved Domains (3) summary
      cd01816
      Location:130 → 201
      Raf_RBD; Ubiquitin domain of Raf serine/threonine kinases
      cd14062
      Location:437 → 685
      STKc_Raf; Catalytic domain of the Serine/Threonine Kinases, Raf (Rapidly Accelerated Fibrosarcoma) kinases
      pfam00130
      Location:209 → 254
      C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)

    3. XM_023514192.1 → XP_023369960.1  serine/threonine-protein kinase B-raf isoform X3

      UniProtKB/TrEMBL
      H0X101
      Conserved Domains (3) summary
      cd01816
      Location:130 → 201
      Raf_RBD; Ubiquitin domain of Raf serine/threonine kinases
      cd14062
      Location:437 → 683
      STKc_Raf; Catalytic domain of the Serine/Threonine Kinases, Raf (Rapidly Accelerated Fibrosarcoma) kinases
      pfam00130
      Location:209 → 254
      C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)

    4. XM_023514194.1 → XP_023369962.1  serine/threonine-protein kinase B-raf isoform X5

      UniProtKB/TrEMBL
      H0X101
      Conserved Domains (3) summary
      cd01816
      Location:130 → 201
      Raf_RBD; Ubiquitin domain of Raf serine/threonine kinases
      cd14062
      Location:437 → 640
      STKc_Raf; Catalytic domain of the Serine/Threonine Kinases, Raf (Rapidly Accelerated Fibrosarcoma) kinases
      pfam00130
      Location:209 → 254
      C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)

    5. XM_023514191.1 → XP_023369959.1  serine/threonine-protein kinase B-raf isoform X2

      UniProtKB/TrEMBL
      H0X101
      Conserved Domains (3) summary
      cd01816
      Location:104 → 175
      Raf_RBD; Ubiquitin domain of Raf serine/threonine kinases
      cd14062
      Location:411 → 663
      STKc_Raf; Catalytic domain of the Serine/Threonine Kinases, Raf (Rapidly Accelerated Fibrosarcoma) kinases
      pfam00130
      Location:183 → 228
      C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
    Nucleotide Protein
    Heading Accession and Version

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