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    FALEC focally amplified lncRNA regulator of ECM1 [ Homo sapiens (human) ]

    Gene ID: 100874054, updated on 10-Dec-2024

    Summary

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    Official Symbol
    FALECprovided by HGNC
    Official Full Name
    focally amplified lncRNA regulator of ECM1provided by HGNC
    Primary source
    HGNC:HGNC:43713
    See related
    Ensembl:ENSG00000228126 MIM:616092; AllianceGenome:HGNC:43713
    Gene type
    ncRNA
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    FAL1; ncRNA-a1; LINC00568
    Expression
    Low expression observed in reference dataset See more
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    Genomic context

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    See FALEC in Genome Data Viewer
    Location:
    1q21.2
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (150515752..150536788)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (149640590..149661674)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (150488228..150509264)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene threonyl-tRNA synthetase 2, mitochondrial Neighboring gene microRNA 6878 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:150482970-150483840 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1689 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1690 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1300 Neighboring gene extracellular matrix protein 1 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:150505206-150506196 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr1:150507812-150509011 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:150515782-150516282 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:150516283-150516783 Neighboring gene CRISPRi-validated cis-regulatory element chr1.8461 Neighboring gene ADAMTSL4 antisense RNA 2 Neighboring gene Sharpr-MPRA regulatory region 6123 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1302 Neighboring gene uncharacterized LOC124904417 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:150523090-150523779 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:150524269-150525138 Neighboring gene ADAMTS like 4 Neighboring gene microRNA 4257

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Bibliography

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    Related articles in PubMed

    1. Up-regulation of lncRNA FALEC indicates prognosis and diagnosis values in cervical cancer. Naizhaer G, et al. Pathol Res Pract, 2019 Aug. PMID 31248657
    2. Long Noncoding RNA FAL1 Promotes Cell Proliferation, Invasion and Epithelial-Mesenchymal Transition Through the PTEN/AKT Signaling Axis in Non-Small Cell Lung Cancer. Pan C, et al. Cell Physiol Biochem, 2017. PMID 28854421
    3. Up-regulation of long noncoding RNA FALEC predicts poor prognosis and promotes melanoma cell proliferation through epigenetically silencing p21. Ni N, et al. Biomed Pharmacother, 2017 Dec. PMID 29196104
    4. LncRNA FAL1 is a negative prognostic biomarker and exhibits pro-oncogenic function in osteosarcoma. Wang Y, et al. J Cell Biochem, 2018 Nov. PMID 29987852
    5. Upregulation of the long non-coding RNA FALEC promotes proliferation and migration of prostate cancer cell lines and predicts prognosis of PCa patients. Zhao R, et al. Prostate, 2017 Jul. PMID 28585762

    See all (25) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. CAF-derived exosomal lncRNA FAL1 promotes chemoresistance to oxaliplatin by regulating autophagy in colorectal cancer.
      Title: CAF-derived exosomal lncRNA FAL1 promotes chemoresistance to oxaliplatin by regulating autophagy in colorectal cancer.
    2. Extracellular vesicular lncRNA FAL1 promotes hepatocellular carcinoma cell proliferation and invasion by inducing macrophage M2 polarization.
      Title: Extracellular vesicular lncRNA FAL1 promotes hepatocellular carcinoma cell proliferation and invasion by inducing macrophage M2 polarization.
    3. LncRNA FALEC increases the proliferation, migration and drug resistance of cholangiocarcinoma through competitive regulation of miR-20a-5p/SHOC2 axis.
      Title: LncRNA FALEC increases the proliferation, migration and drug resistance of cholangiocarcinoma through competitive regulation of miR-20a-5p/SHOC2 axis.
    4. LncFALEC recruits ART5/PARP1 and promotes castration-resistant prostate cancer through enhancing PARP1-meditated self PARylation.
      Title: LncFALEC recruits ART5/PARP1 and promotes castration-resistant prostate cancer through enhancing PARP1-meditated self PARylation.
    5. Long non-coding RNA FALEC promotes colorectal cancer progression via regulating miR-2116-3p-targeted PIWIL1.
      Title: Long non-coding RNA FALEC promotes colorectal cancer progression via regulating miR-2116-3p-targeted PIWIL1.
    6. LncRNA FALEC promotes proliferation, migration, and invasion of PTC cells through regulating Wnt/beta-catenin signaling pathway.
      Title: LncRNA FALEC promotes proliferation, migration, and invasion of PTC cells through regulating Wnt/β-catenin signaling pathway.
    7. LncRNA FAL1 promotes the development of oral squamous cell carcinoma through regulating the microRNA-761/CRKL pathway.
      Title: LncRNA FAL1 promotes the development of oral squamous cell carcinoma through regulating the microRNA-761/CRKL pathway.
    8. The focally amplified long non-coding RNA in epithelial cancer (FALEC) was found downregulated in the tissues of tongue squamous cell carcinoma (TSCC) and was predicted to present a good prognosis by bioinformatics analysis. The data revealed that FALEC acted as a tumor suppressor in TSCC and may aid in developing a novel potential therapeutic strategy against TSCC.
      Title: Long noncoding RNA FALEC inhibits proliferation and metastasis of tongue squamous cell carcinoma by epigenetically silencing ECM1 through EZH2.
    9. FALEC is overexpressed in endometrial cancer tissues and cells, and involved in regulating cell proliferation and cell-cycle.
      Title: FALEC exerts oncogenic properties to regulate cell proliferation and cell-cycle in endometrial cancer.
    10. FALEC was a potential molecular marker used to diagnose cervical cancer and evaluate prognosis
      Title: Up-regulation of lncRNA FALEC indicates prognosis and diagnosis values in cervical cancer.
    Submit: New GeneRIF Correction See all GeneRIFs (21)

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    General gene information

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    Other Names

    • focally amplified lncRNA on chromosome 1
    • focally amplified long non-coding RNA in epithelial cancer
    • long intergenic non-protein coding RNA 568
    • noncoding RNA-activating 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    RNA

    1. NR_051960.2 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL356356
      Related
      ENST00000718313.1

    2. NR_186305.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL356356
      Related
      ENST00000416894.2

    3. NR_186306.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL356356
      Related
      ENST00000717990.1

    4. NR_186307.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL356356

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      150515752..150536788
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      149640590..149661674
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version

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    Research Materials