U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination
    • Showing Current items.

    HTT-AS HTT antisense RNA [ Homo sapiens (human) ]

    Gene ID: 100750326, updated on 27-Nov-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    HTT-ASprovided by HGNC
    Official Full Name
    HTT antisense RNAprovided by HGNC
    Primary source
    HGNC:HGNC:37118
    See related
    Ensembl:ENSG00000251075 AllianceGenome:HGNC:37118
    Gene type
    ncRNA
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    HTTAS; HTT-AS1
    Summary
    Predicted to be involved in regulation of gene expression. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Low expression observed in reference dataset See more
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See HTT-AS in Genome Data Viewer
    Location:
    4p16.3
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 4 NC_000004.12 (3046139..3074624, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 4 NC_060928.1 (3044858..3073351, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (3047866..3076351, complement)

    Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene H3K27ac hESC enhancer GRCh37_chr4:2964791-2965324 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:2965325-2965858 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15196 Neighboring gene G protein-coupled receptor kinase 4 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr4:3011160-3012359 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21206 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:3022951-3023451 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21208 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21209 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21210 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21211 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15197 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21212 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21213 Neighboring gene RNA, U6 small nuclear 204, pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21214 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15198 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15199 Neighboring gene huntingtin repeat instability region Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15200 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21215 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21216 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21217 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21218 Neighboring gene RNA, U7 small nuclear 33 pseudogene Neighboring gene huntingtin Neighboring gene ReSE screen-validated silencer GRCh37_chr4:3137138-3137317 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15201 Neighboring gene Sharpr-MPRA regulatory region 10599 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:3215178-3215678 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:3215679-3216179 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:3239294-3239953 Neighboring gene OCT4-NANOG-H3K4me1 hESC enhancer GRCh37_chr4:3239954-3240612 Neighboring gene ReSE screen-validated silencer GRCh37_chr4:3248264-3248439 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:3252404-3253300 Neighboring gene Myb/SANT DNA binding domain containing 1

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Expression

    Go to the top of the page Help
    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Roles of long noncoding RNAs in brain development, functional diversification and neurodegenerative diseases. Wu P, et al. Brain Res Bull, 2013 Aug. PMID 23756188
    2. A natural antisense transcript at the Huntington's disease repeat locus regulates HTT expression. Chung DW, et al. Hum Mol Genet, 2011 Sep 1. PMID 21672921, Free PMC Article
    3. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. Kimura K, et al. Genome Res, 2006 Jan. PMID 16344560, Free PMC Article
    4. A high-throughput screening to identify small molecules that suppress huntingtin promoter activity or activate huntingtin-antisense promoter activity. Khaled HG, et al. Sci Rep, 2021 Mar 17. PMID 33731741, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Phenotypes

    Go to the top of the page Help

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

    Go to the top of the page Help

    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    General gene information

    Go to the top of the page Help

    Other Names

    • HTT antisense RNA (head to head)
    • HTT antisense RNA 1 (head to head)
    • HTT antisense RNA 1 (non-protein coding)

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    RNA

    1. NR_045414.2 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL390059, AL390065

    2. NR_185914.2 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL390059, AL390065
      Related
      ENST00000660368.2

    3. NR_185915.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL390059, AL390065

    4. NR_185916.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL390059, AL390065

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000004.12 Reference GRCh38.p14 Primary Assembly

      Range
      3046139..3074624 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060928.1 Alternate T2T-CHM13v2.0

      Range
      3044858..3073351 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials