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    kmt2d lysine methyltransferase 2D [ Xenopus tropicalis (tropical clawed frog) ]

    Gene ID: 100494109, updated on 9-Dec-2024

    Summary

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    Official Symbol
    kmt2dprovided by Xenbase
    Official Full Name
    lysine methyltransferase 2Dprovided by Xenbase
    Primary source
    Xenbase:XB-GENE-855725
    See related
    AllianceGenome:Xenbase:XB-GENE-855725
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Xenopus tropicalis
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana
    Also known as
    mll2
    Summary
    Predicted to enable metal ion binding activity and methyltransferase activity. Predicted to act upstream of or within chromatin organization; methylation; and protein-containing complex organization. Predicted to be located in nucleus. Human ortholog(s) of this gene implicated in Kabuki syndrome; carcinoma (multiple); and intracranial aneurysm. Orthologous to human KMT2D (lysine methyltransferase 2D). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See kmt2d in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    55
    Annotation release Status Assembly Chr Location
    104 current UCB_Xtro_10.0 (GCF_000004195.4) 2 NC_030678.2 (136354976..136428115, complement)
    103 previous assembly Xenopus_tropicalis_v9.1 (GCF_000004195.3) 2 NC_030678.1 (133076855..133149935, complement)

    Chromosome 2 - NC_030678.2Genomic Context describing neighboring genes Neighboring gene dendrin Neighboring gene protein kinase, AMP-activated, gamma 1 non-catalytic subunit Neighboring gene RHEB like 1 Neighboring gene desert hedgehog

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by Xenbase

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within chromatin organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within methylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    histone-lysine N-methyltransferase 2D
    Names
    lysine (K)-specific methyltransferase 2D

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Xenopus tropicalis Annotation Release 104 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference UCB_Xtro_10.0 Primary Assembly

    Genomic

    1. NC_030678.2 Reference UCB_Xtro_10.0 Primary Assembly

      Range
      136354976..136428115 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_031897155.1 → XP_031753015.1  histone-lysine N-methyltransferase 2D isoform X6

      UniProtKB/TrEMBL
      A0A5S6LCH1, A0A8J1J7M0
      Conserved Domains (13) summary
      smart00398
      Location:1456 → 1507
      HMG; high mobility group
      PHA03307
      Location:1740 → 2110
      PHA03307; transcriptional regulator ICP4; Provisional
      cd15509
      Location:220 → 265
      PHD1_KMT2C_like; PHD finger 1 found in Histone-lysine N-methyltransferase 2C (KMT2C) and 2D (KMT2D)
      cd15513
      Location:859 → 905
      PHD5_KMT2C_like; PHD finger 5 found in Histone-lysine N-methyltransferase 2C (KMT2C) and PHD finger 4 found in KMT2D
      cd15595
      Location:267 → 312
      PHD2_KMT2D; PHD finger 2 found in Histone-lysine N-methyltransferase 2D (KMT2D)
      cd15597
      Location:808 → 858
      PHD3_KMT2D; PHD finger 3 found in Histone-lysine N-methyltransferase 2D (KMT2D)
      cd15601
      Location:936 → 986
      PHD5_KMT2D; PHD finger 5 found in Histone-lysine N-methyltransferase 2D (KMT2D)
      cd15695
      Location:126 → 209
      ePHD1_KMT2D; Extended PHD finger 1 found in histone-lysine N-methyltransferase 2D (KMT2D)
      cd15698
      Location:5620 → 5726
      ePHD2_KMT2D; Extended PHD finger 2 found in histone-lysine N-methyltransferase 2D (KMT2D)
      pfam09606
      Location:3048 → 3377
      Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
      cd19171
      Location:5972 → 6124
      SET_KMT2C_2D; SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2C (KMT2C), 2D (KMT2D) and similar proteins
      pfam05964
      Location:5769 → 5811
      FYRN; F/Y-rich N-terminus
      pfam05965
      Location:5826 → 5910
      FYRC; F/Y rich C-terminus

    2. XM_031897153.1 → XP_031753013.1  histone-lysine N-methyltransferase 2D isoform X4

      UniProtKB/TrEMBL
      A0A5S6LCH1, A0A8J1J569
      Conserved Domains (13) summary
      smart00398
      Location:1456 → 1507
      HMG; high mobility group
      PHA03307
      Location:1740 → 2110
      PHA03307; transcriptional regulator ICP4; Provisional
      cd15509
      Location:220 → 265
      PHD1_KMT2C_like; PHD finger 1 found in Histone-lysine N-methyltransferase 2C (KMT2C) and 2D (KMT2D)
      cd15513
      Location:859 → 905
      PHD5_KMT2C_like; PHD finger 5 found in Histone-lysine N-methyltransferase 2C (KMT2C) and PHD finger 4 found in KMT2D
      cd15595
      Location:267 → 312
      PHD2_KMT2D; PHD finger 2 found in Histone-lysine N-methyltransferase 2D (KMT2D)
      cd15597
      Location:808 → 858
      PHD3_KMT2D; PHD finger 3 found in Histone-lysine N-methyltransferase 2D (KMT2D)
      cd15601
      Location:936 → 986
      PHD5_KMT2D; PHD finger 5 found in Histone-lysine N-methyltransferase 2D (KMT2D)
      cd15695
      Location:126 → 209
      ePHD1_KMT2D; Extended PHD finger 1 found in histone-lysine N-methyltransferase 2D (KMT2D)
      cd15698
      Location:5622 → 5728
      ePHD2_KMT2D; Extended PHD finger 2 found in histone-lysine N-methyltransferase 2D (KMT2D)
      pfam09606
      Location:3048 → 3377
      Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
      cd19171
      Location:5974 → 6126
      SET_KMT2C_2D; SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2C (KMT2C), 2D (KMT2D) and similar proteins
      pfam05964
      Location:5771 → 5813
      FYRN; F/Y-rich N-terminus
      pfam05965
      Location:5828 → 5912
      FYRC; F/Y rich C-terminus

    3. XM_031897154.1 → XP_031753014.1  histone-lysine N-methyltransferase 2D isoform X5

      UniProtKB/TrEMBL
      A0A5S6LCH1, A0A8J1J563
      Conserved Domains (13) summary
      smart00398
      Location:1421 → 1472
      HMG; high mobility group
      PHA03307
      Location:1705 → 2075
      PHA03307; transcriptional regulator ICP4; Provisional
      cd15509
      Location:220 → 265
      PHD1_KMT2C_like; PHD finger 1 found in Histone-lysine N-methyltransferase 2C (KMT2C) and 2D (KMT2D)
      cd15513
      Location:859 → 905
      PHD5_KMT2C_like; PHD finger 5 found in Histone-lysine N-methyltransferase 2C (KMT2C) and PHD finger 4 found in KMT2D
      cd15595
      Location:267 → 312
      PHD2_KMT2D; PHD finger 2 found in Histone-lysine N-methyltransferase 2D (KMT2D)
      cd15597
      Location:808 → 858
      PHD3_KMT2D; PHD finger 3 found in Histone-lysine N-methyltransferase 2D (KMT2D)
      cd15601
      Location:936 → 986
      PHD5_KMT2D; PHD finger 5 found in Histone-lysine N-methyltransferase 2D (KMT2D)
      cd15695
      Location:126 → 209
      ePHD1_KMT2D; Extended PHD finger 1 found in histone-lysine N-methyltransferase 2D (KMT2D)
      cd15698
      Location:5587 → 5693
      ePHD2_KMT2D; Extended PHD finger 2 found in histone-lysine N-methyltransferase 2D (KMT2D)
      pfam09606
      Location:3013 → 3342
      Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
      cd19171
      Location:5939 → 6091
      SET_KMT2C_2D; SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2C (KMT2C), 2D (KMT2D) and similar proteins
      pfam05964
      Location:5736 → 5778
      FYRN; F/Y-rich N-terminus
      pfam05965
      Location:5793 → 5877
      FYRC; F/Y rich C-terminus

    4. XM_031897151.1 → XP_031753011.1  histone-lysine N-methyltransferase 2D isoform X2

      UniProtKB/TrEMBL
      A0A5S6LCH1, A0A8J1J8L3
      Conserved Domains (13) summary
      smart00398
      Location:1461 → 1512
      HMG; high mobility group
      PHA03307
      Location:1744 → 2114
      PHA03307; transcriptional regulator ICP4; Provisional
      cd15509
      Location:220 → 265
      PHD1_KMT2C_like; PHD finger 1 found in Histone-lysine N-methyltransferase 2C (KMT2C) and 2D (KMT2D)
      cd15513
      Location:859 → 905
      PHD5_KMT2C_like; PHD finger 5 found in Histone-lysine N-methyltransferase 2C (KMT2C) and PHD finger 4 found in KMT2D
      cd15595
      Location:267 → 312
      PHD2_KMT2D; PHD finger 2 found in Histone-lysine N-methyltransferase 2D (KMT2D)
      cd15597
      Location:808 → 858
      PHD3_KMT2D; PHD finger 3 found in Histone-lysine N-methyltransferase 2D (KMT2D)
      cd15601
      Location:936 → 986
      PHD5_KMT2D; PHD finger 5 found in Histone-lysine N-methyltransferase 2D (KMT2D)
      cd15695
      Location:126 → 209
      ePHD1_KMT2D; Extended PHD finger 1 found in histone-lysine N-methyltransferase 2D (KMT2D)
      cd15698
      Location:5626 → 5732
      ePHD2_KMT2D; Extended PHD finger 2 found in histone-lysine N-methyltransferase 2D (KMT2D)
      pfam09606
      Location:3052 → 3381
      Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
      cd19171
      Location:5978 → 6130
      SET_KMT2C_2D; SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2C (KMT2C), 2D (KMT2D) and similar proteins
      pfam05964
      Location:5775 → 5817
      FYRN; F/Y-rich N-terminus
      pfam05965
      Location:5832 → 5916
      FYRC; F/Y rich C-terminus

    5. XM_031897152.1 → XP_031753012.1  histone-lysine N-methyltransferase 2D isoform X3

      UniProtKB/TrEMBL
      A0A5S6LCH1, A0A8J1J566
      Conserved Domains (13) summary
      smart00398
      Location:1461 → 1512
      HMG; high mobility group
      PHA03307
      Location:1745 → 2115
      PHA03307; transcriptional regulator ICP4; Provisional
      cd15509
      Location:220 → 265
      PHD1_KMT2C_like; PHD finger 1 found in Histone-lysine N-methyltransferase 2C (KMT2C) and 2D (KMT2D)
      cd15513
      Location:859 → 905
      PHD5_KMT2C_like; PHD finger 5 found in Histone-lysine N-methyltransferase 2C (KMT2C) and PHD finger 4 found in KMT2D
      cd15595
      Location:267 → 312
      PHD2_KMT2D; PHD finger 2 found in Histone-lysine N-methyltransferase 2D (KMT2D)
      cd15597
      Location:808 → 858
      PHD3_KMT2D; PHD finger 3 found in Histone-lysine N-methyltransferase 2D (KMT2D)
      cd15601
      Location:936 → 986
      PHD5_KMT2D; PHD finger 5 found in Histone-lysine N-methyltransferase 2D (KMT2D)
      cd15695
      Location:126 → 209
      ePHD1_KMT2D; Extended PHD finger 1 found in histone-lysine N-methyltransferase 2D (KMT2D)
      cd15698
      Location:5625 → 5731
      ePHD2_KMT2D; Extended PHD finger 2 found in histone-lysine N-methyltransferase 2D (KMT2D)
      pfam09606
      Location:3053 → 3382
      Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
      cd19171
      Location:5977 → 6129
      SET_KMT2C_2D; SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2C (KMT2C), 2D (KMT2D) and similar proteins
      pfam05964
      Location:5774 → 5816
      FYRN; F/Y-rich N-terminus
      pfam05965
      Location:5831 → 5915
      FYRC; F/Y rich C-terminus

    6. XM_018091677.2 → XP_017947166.2  histone-lysine N-methyltransferase 2D isoform X1

      UniProtKB/TrEMBL
      A0A5S6LCH1, A0A8J0SYQ0
      Conserved Domains (13) summary
      smart00398
      Location:1461 → 1512
      HMG; high mobility group
      PHA03307
      Location:1745 → 2115
      PHA03307; transcriptional regulator ICP4; Provisional
      cd15509
      Location:220 → 265
      PHD1_KMT2C_like; PHD finger 1 found in Histone-lysine N-methyltransferase 2C (KMT2C) and 2D (KMT2D)
      cd15513
      Location:859 → 905
      PHD5_KMT2C_like; PHD finger 5 found in Histone-lysine N-methyltransferase 2C (KMT2C) and PHD finger 4 found in KMT2D
      cd15595
      Location:267 → 312
      PHD2_KMT2D; PHD finger 2 found in Histone-lysine N-methyltransferase 2D (KMT2D)
      cd15597
      Location:808 → 858
      PHD3_KMT2D; PHD finger 3 found in Histone-lysine N-methyltransferase 2D (KMT2D)
      cd15601
      Location:936 → 986
      PHD5_KMT2D; PHD finger 5 found in Histone-lysine N-methyltransferase 2D (KMT2D)
      cd15695
      Location:126 → 209
      ePHD1_KMT2D; Extended PHD finger 1 found in histone-lysine N-methyltransferase 2D (KMT2D)
      cd15698
      Location:5627 → 5733
      ePHD2_KMT2D; Extended PHD finger 2 found in histone-lysine N-methyltransferase 2D (KMT2D)
      pfam09606
      Location:3053 → 3382
      Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
      cd19171
      Location:5979 → 6131
      SET_KMT2C_2D; SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2C (KMT2C), 2D (KMT2D) and similar proteins
      pfam05964
      Location:5776 → 5818
      FYRN; F/Y-rich N-terminus
      pfam05965
      Location:5833 → 5917
      FYRC; F/Y rich C-terminus
    Nucleotide Protein Strain
    Heading Accession and Version

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