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    dgkh diacylglycerol kinase, eta [ Xenopus tropicalis (tropical clawed frog) ]

    Gene ID: 100486581, updated on 14-Nov-2024

    Summary

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    Official Symbol
    dgkhprovided by Xenbase
    Official Full Name
    diacylglycerol kinase, etaprovided by Xenbase
    Primary source
    Xenbase:XB-GENE-955943
    See related
    Ensembl:ENSXETG00000014560 AllianceGenome:Xenbase:XB-GENE-955943
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Xenopus tropicalis
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana
    Summary
    Predicted to enable ATP-dependent diacylglycerol kinase activity. Predicted to be involved in diacylglycerol metabolic process; intracellular signal transduction; and phosphatidic acid biosynthetic process. Predicted to act upstream of or within glycerolipid metabolic process; phospholipase C-activating G protein-coupled receptor signaling pathway; and phosphorylation. Predicted to be active in plasma membrane. Orthologous to human DGKH (diacylglycerol kinase eta). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See dgkh in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    31
    Annotation release Status Assembly Chr Location
    104 current UCB_Xtro_10.0 (GCF_000004195.4) 2 NC_030678.2 (132631205..132775359)
    103 previous assembly Xenopus_tropicalis_v9.1 (GCF_000004195.3) 2 NC_030678.1 (129380081..129525726)

    Chromosome 2 - NC_030678.2Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC116408881 Neighboring gene von Willebrand factor A domain containing 8 Neighboring gene A-kinase anchoring protein 11 Neighboring gene TNF superfamily member 11

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by Xenbase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP-dependent diacylglycerol kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ATP-dependent diacylglycerol kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in diacylglycerol metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within glycerolipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in intracellular signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within lipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in phosphatidic acid biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within phospholipase C-activating G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    diacylglycerol kinase eta

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Xenopus tropicalis Annotation Release 104 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference UCB_Xtro_10.0 Primary Assembly

    Genomic

    1. NC_030678.2 Reference UCB_Xtro_10.0 Primary Assembly

      Range
      132631205..132775359
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_004911834.4 → XP_004911891.1  diacylglycerol kinase eta isoform X2

      UniProtKB/TrEMBL
      A0A6I8RHW0, A0A8J0QWI6
      Related
      ENSXETP00000031872.5, ENSXETT00000031872.5
      Conserved Domains (6) summary
      cd09576
      Location:1163 → 1227
      SAM_DGK-eta; SAM domain of diacylglycerol kinase eta
      smart00109
      Location:254 → 304
      C1; Protein kinase C conserved region 1 (C1) domains (Cysteine-rich domains)
      smart00045
      Location:786 → 943
      DAGKa; Diacylglycerol kinase accessory domain (presumed)
      smart00046
      Location:341 → 463
      DAGKc; Diacylglycerol kinase catalytic domain (presumed)
      cd00029
      Location:182 → 231
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      cd13274
      Location:73 → 169
      PH_DGK_type2; Type 2 Diacylglycerol kinase Pleckstrin homology (PH) domain

    2. XM_012957746.3 → XP_012813200.1  diacylglycerol kinase eta isoform X3

      UniProtKB/TrEMBL
      A0A6I8QCL2, A0A6I8RHW0
      Related
      ENSXETP00000070441.2, ENSXETT00000103052.2
      Conserved Domains (6) summary
      cd09576
      Location:1162 → 1226
      SAM_DGK-eta; SAM domain of diacylglycerol kinase eta
      smart00109
      Location:253 → 303
      C1; Protein kinase C conserved region 1 (C1) domains (Cysteine-rich domains)
      smart00045
      Location:785 → 942
      DAGKa; Diacylglycerol kinase accessory domain (presumed)
      smart00046
      Location:340 → 462
      DAGKc; Diacylglycerol kinase catalytic domain (presumed)
      cd00029
      Location:181 → 230
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      cd13274
      Location:72 → 168
      PH_DGK_type2; Type 2 Diacylglycerol kinase Pleckstrin homology (PH) domain

    3. XM_012957745.3 → XP_012813199.1  diacylglycerol kinase eta isoform X1

      UniProtKB/TrEMBL
      A0A6I8RHW0, A0A8J0SDW2
      Related
      ENSXETP00000081166.2, ENSXETT00000084871.2
      Conserved Domains (6) summary
      cd09576
      Location:1173 → 1237
      SAM_DGK-eta; SAM domain of diacylglycerol kinase eta
      smart00109
      Location:264 → 314
      C1; Protein kinase C conserved region 1 (C1) domains (Cysteine-rich domains)
      smart00045
      Location:796 → 953
      DAGKa; Diacylglycerol kinase accessory domain (presumed)
      smart00046
      Location:351 → 473
      DAGKc; Diacylglycerol kinase catalytic domain (presumed)
      cd00029
      Location:192 → 241
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      cd13274
      Location:83 → 179
      PH_DGK_type2; Type 2 Diacylglycerol kinase Pleckstrin homology (PH) domain

    4. XM_012957748.3 → XP_012813202.1  diacylglycerol kinase eta isoform X4

      UniProtKB/TrEMBL
      A0A8J0SGS9, F6WIA3
      Conserved Domains (5) summary
      smart00109
      Location:264 → 314
      C1; Protein kinase C conserved region 1 (C1) domains (Cysteine-rich domains)
      smart00045
      Location:796 → 953
      DAGKa; Diacylglycerol kinase accessory domain (presumed)
      smart00046
      Location:351 → 473
      DAGKc; Diacylglycerol kinase catalytic domain (presumed)
      cd00029
      Location:192 → 241
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      cd13274
      Location:83 → 179
      PH_DGK_type2; Type 2 Diacylglycerol kinase Pleckstrin homology (PH) domain
    Nucleotide Protein Strain
    Heading Accession and Version

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