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    fgfr3 fibroblast growth factor receptor 3 (achondroplasia, thanatophoric dwarfism) [ Xenopus tropicalis (tropical clawed frog) ]

    Gene ID: 100196923, updated on 14-Nov-2024

    Summary

    Official Symbol
    fgfr3provided by Xenbase
    Official Full Name
    fibroblast growth factor receptor 3 (achondroplasia, thanatophoric dwarfism)provided by Xenbase
    Primary source
    Xenbase:XB-GENE-479255
    See related
    Ensembl:ENSXETG00000002396 AllianceGenome:Xenbase:XB-GENE-479255
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Xenopus tropicalis
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana
    Also known as
    ach; cek2; jtk4; cd333; fgfr-3; hsfgfr3ex
    Summary
    Predicted to enable ATP binding activity and fibroblast growth factor receptor activity. Acts upstream of or within embryonic body morphogenesis. Predicted to be located in plasma membrane. Is expressed in anatomical system; ectoderm; and mesenchyme. Human ortholog(s) of this gene implicated in several diseases, including Human papillomavirus infectious disease; SADDAN; acanthosis nigricans; bone disease (multiple); and carcinoma (multiple). Orthologous to human FGFR3 (fibroblast growth factor receptor 3). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
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    Genomic context

    See fgfr3 in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    104 current UCB_Xtro_10.0 (GCF_000004195.4) 1 NC_030677.2 (20843644..20911445)
    103 previous assembly Xenopus_tropicalis_v9.1 (GCF_000004195.3) 1 NC_030677.1 (12769288..12836770, complement)

    Chromosome 1 - NC_030677.2Genomic Context describing neighboring genes Neighboring gene transforming acidic coiled-coil containing protein 3 Neighboring gene U4 spliceosomal RNA Neighboring gene uncharacterized LOC116408434 Neighboring gene leucine zipper-EF-hand containing transmembrane protein 1 Neighboring gene nuclear receptor binding SET domain protein 2

    Genomic regions, transcripts, and products

    General gene information

    Gene Ontology Provided by Xenbase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables GPI-linked ephrin receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables boss receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables brain-derived neurotrophic factor receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables epidermal growth factor receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables fibroblast growth factor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables fibroblast growth factor receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables fibroblast growth factor receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables hepatocyte growth factor receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables insulin receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables insulin-like growth factor receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables macrophage colony-stimulating factor receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables placental growth factor receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables platelet-derived growth factor alpha-receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables platelet-derived growth factor beta-receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein tyrosine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein tyrosine kinase collagen receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables stem cell factor receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables transmembrane-ephrin receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables vascular endothelial growth factor receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    part_of receptor complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    fibroblast growth factor receptor 3
    NP_001135467.1
    XP_012812743.1
    XP_012812749.1
    XP_012812753.1
    XP_012812760.1
    XP_031752005.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001141995.1NP_001135467.1  fibroblast growth factor receptor 3

      See identical proteins and their annotated locations for NP_001135467.1

      Status: PROVISIONAL

      Source sequence(s)
      BC168038
      UniProtKB/TrEMBL
      A0A6I8RGC9, B4F6W5
      Related
      ENSXETP00000080689.2, ENSXETT00000086796.2
      Conserved Domains (4) summary
      cd05857
      Location:177261
      Ig2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor
      cd05858
      Location:284373
      Ig3_FGFR-2; Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor 2 (FGFR2)
      cd05100
      Location:474807
      PTKc_FGFR3; Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 3
      smart00408
      Location:74129
      IGc2; Immunoglobulin C-2 Type

    RefSeqs of Annotated Genomes: Xenopus tropicalis Annotation Release 104 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference UCB_Xtro_10.0 Primary Assembly

    Genomic

    1. NC_030677.2 Reference UCB_Xtro_10.0 Primary Assembly

      Range
      20843644..20911445
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_012957289.3XP_012812743.1  fibroblast growth factor receptor 3 isoform X5

      UniProtKB/TrEMBL
      A0A6I8RGC9, A0A8J0SG86
      Conserved Domains (4) summary
      cd05857
      Location:177261
      Ig2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor
      cd05100
      Location:476809
      PTKc_FGFR3; Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 3
      smart00408
      Location:74129
      IGc2; Immunoglobulin C-2 Type
      cd04974
      Location:284371
      Ig3_FGFR; Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor (FGFR)
    2. XM_012957306.3XP_012812760.1  fibroblast growth factor receptor 3 isoform X2

      UniProtKB/TrEMBL
      A0A6I8RGC9, A0A6I8SYT7, F6V1T7
      Related
      ENSXETP00000005103.3, ENSXETT00000005103.4
      Conserved Domains (4) summary
      cd05857
      Location:177261
      Ig2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor
      cd05100
      Location:475808
      PTKc_FGFR3; Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 3
      smart00408
      Location:74129
      IGc2; Immunoglobulin C-2 Type
      cd04974
      Location:284371
      Ig3_FGFR; Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor (FGFR)
    3. XM_012957299.3XP_012812753.1  fibroblast growth factor receptor 3 isoform X3

      UniProtKB/TrEMBL
      A0A6I8RGC9, A0A6I8RGZ1
      Related
      ENSXETP00000080879.2, ENSXETT00000103276.2
      Conserved Domains (7) summary
      cd04974
      Location:284371
      Ig3_FGFR; Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor (FGFR)
      cd05857
      Location:177261
      Ig2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor
      cd05100
      Location:475808
      PTKc_FGFR3; Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 3
      smart00408
      Location:74129
      IGc2; Immunoglobulin C-2 Type
      smart00409
      Location:75145
      IG; Immunoglobulin
      smart00410
      Location:276370
      IG_like; Immunoglobulin like
      pfam07714
      Location:488764
      Pkinase_Tyr; Protein tyrosine kinase
    4. XM_031896145.1XP_031752005.1  fibroblast growth factor receptor 3 isoform X4

      UniProtKB/TrEMBL
      A0A6I8RGC9, A0A8J1J4S6
      Conserved Domains (5) summary
      cd05100
      Location:474807
      PTKc_FGFR3; Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 3
      smart00408
      Location:74129
      IGc2; Immunoglobulin C-2 Type
      cd00096
      Location:269272
      Ig; Ig strand A [structural motif]
      cd05857
      Location:167261
      IgI_2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor; member of the I-set of IgSF domains
      cl11960
      Location:269373
      Ig; Immunoglobulin domain
    5. XM_012957295.3XP_012812749.1  fibroblast growth factor receptor 3 isoform X1

      UniProtKB/TrEMBL
      A0A6I8RGC9, A0A6I8SPF3
      Related
      ENSXETP00000099567.2, ENSXETT00000070721.2
      Conserved Domains (4) summary
      cd05857
      Location:177261
      Ig2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor
      cd05858
      Location:284373
      Ig3_FGFR-2; Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor 2 (FGFR2)
      cd05100
      Location:475808
      PTKc_FGFR3; Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 3
      smart00408
      Location:74129
      IGc2; Immunoglobulin C-2 Type