SH3RF1 SH3 domain containing ring finger 1 [Pongo abelii (Sumatran orangutan)] - Gene

Summary

Gene symbol: SH3RF1
Gene description: SH3 domain containing ring finger 1
Locus tag: CR201_G0014141
See related: Ensembl:ENSPPYG00000015189
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Pongo abelii
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Pongo
Also known as: POSH
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 3

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	NHGRI_mPonAbe1-v2.0_pri (GCF_028885655.2)	3	NC_071988.2 (191260628..191438321, complement)
RS_2023_04	previous assembly	NHGRI_mPonAbe1-v1.1-hic.freeze_pri (GCF_028885655.1)	4	NC_071989.1 (191297925..191475482, complement)

Chromosome 3 - NC_071988.2 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

General gene information

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Markers

RH102438 (e-PCR)
- UniSTS:96772

RH123053 (e-PCR)
- UniSTS:135446

SHGC-67757 (e-PCR)
- UniSTS:72253

SHGC-24796 (e-PCR)
- UniSTS:11388

RH122611 (e-PCR)
- UniSTS:135056

D4S2770E (e-PCR)
- UniSTS:153746

G33624 (e-PCR)
- UniSTS:23718

RH92786 (e-PCR)
- UniSTS:90025

D4S3122 (e-PCR)
- UniSTS:27589

D4S2840 (e-PCR)
- UniSTS:33497

RH123022 (e-PCR)
- UniSTS:135413

D4S516 (e-PCR)
- UniSTS:70646

SH3MD2__6826 (e-PCR)
- UniSTS:466430

Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables protein binding	IEA Inferred from Electronic Annotation more info	PubMed
enables ubiquitin protein ligase activity	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in positive regulation of JNK cascade	IEA Inferred from Electronic Annotation more info	PubMed
involved_in positive regulation of proteasomal ubiquitin-dependent protein catabolic process	IEA Inferred from Electronic Annotation more info	PubMed
involved_in protein ubiquitination	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: E3 ubiquitin-protein ligase SH3RF1

Names: RING-type E3 ubiquitin transferase SH3RF1; SH3 domain-containing RING finger protein 1; plenty of SH3s; putative E3 ubiquitin-protein ligase SH3RF1

NP_001125455.1

EC 2.3.2.27

XP_009238710.1

EC 2.3.2.27

XP_054409181.1

EC 2.3.2.27

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001131983.1 → NP_001125455.1 E3 ubiquitin-protein ligase SH3RF1

See identical proteins and their annotated locations for NP_001125455.1

Status: PROVISIONAL

Source sequence(s)

CR858578

UniProtKB/Swiss-Prot

Q5RBR0

UniProtKB/TrEMBL

A0A2J8VZU1

Related

ENSPPYP00000016972.2, ENSPPYT00000017658.3

Conserved Domains (5) summary

cd11785
Location:833 → 887

SH3_SH3RF_C; C-terminal (Fourth) Src Homology 3 domain of SH3 domain containing ring finger 1 (SH3RF1), SH3RF3, and similar domains

cd11926
Location:449 → 503

SH3_SH3RF1_3; Third Src Homology 3 domain of SH3 domain containing ring finger 1, an E3 ubiquitin-protein ligase

cd11930
Location:200 → 254

SH3_SH3RF1_2; Second Src Homology 3 domain of SH3 domain containing ring finger protein 1, an E3 ubiquitin-protein ligase

cd00162
Location:11 → 56

RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...

cl17036
Location:137 → 190

SH3; Src Homology 3 domain superfamily

RefSeqs of Annotated Genomes: GCF_028885655.2-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference NHGRI_mPonAbe1-v2.0_pri Primary Assembly

Genomic

NC_071988.2 Reference NHGRI_mPonAbe1-v2.0_pri Primary Assembly

Range

191260628..191438321 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_009240435.4 → XP_009238710.1 E3 ubiquitin-protein ligase SH3RF1 isoform X1

UniProtKB/TrEMBL

A0A2J8VZS9, A0A2J8VZU1, A0A663DBY2, H2PEQ5

Conserved Domains (6) summary

cd11785
Location:833 → 887

SH3_SH3RF_C; C-terminal (Fourth) Src Homology 3 domain of SH3 domain containing ring finger 1 (SH3RF1), SH3RF3, and similar domains

cd11926
Location:449 → 503

SH3_SH3RF1_3; Third Src Homology 3 domain of SH3 domain containing ring finger 1, an E3 ubiquitin-protein ligase

cd11930
Location:200 → 254

SH3_SH3RF1_2; Second Src Homology 3 domain of SH3 domain containing ring finger protein 1, an E3 ubiquitin-protein ligase

cd16748
Location:8 → 55

RING-HC_SH3RF1; RING finger, HC subclass, found in SH3 domain-containing RING finger protein 1 (SH3RF1) and similar proteins

cl17036
Location:137 → 190

SH3; Src Homology 3 domain superfamily

cl26464
Location:503 → 845

Atrophin-1; Atrophin-1 family
XM_054553206.2 → XP_054409181.1 E3 ubiquitin-protein ligase SH3RF1 isoform X2

UniProtKB/TrEMBL

A0A2J8VZU1