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    si:ch211-74m13.1 si:ch211-74m13.1 [ Danio rerio (zebrafish) ]

    Gene ID: 100149459, updated on 27-Dec-2024

    Summary

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    Official Symbol
    si:ch211-74m13.1provided by ZNC
    Official Full Name
    si:ch211-74m13.1provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-081104-12
    See related
    Ensembl:ENSDARG00000095312 AllianceGenome:ZFIN:ZDB-GENE-081104-12
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Summary
    Predicted to enable integrin binding activity. Predicted to act upstream of or within cell adhesion. Predicted to be located in membrane. Orthologous to human ICAM4 (intercellular adhesion molecule 4 (Landsteiner-Wiener blood group)). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See si:ch211-74m13.1 in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 3 NC_007114.7 (54776171..54792813)
    105 previous assembly GRCz10 (GCF_000002035.5) 3 NC_007114.6 (54521619..54537304)

    Chromosome 3 - NC_007114.7Genomic Context describing neighboring genes Neighboring gene sphingosine-1-phosphate receptor 2 Neighboring gene intercellular adhesion molecule 3 Neighboring gene intercellular adhesion molecule 2 Neighboring gene UBA-like domain containing 1b

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Suppressing STAT3 activity protects the endothelial barrier from VEGF-mediated vascular permeability. Wang L, et al. Dis Model Mech, 2021 Nov 1. PMID 34542605, Free PMC Article
    2. Zebrafish VCAP1X2 regulates cardiac contractility and proliferation of cardiomyocytes and epicardial cells. Hsieh FC, et al. Sci Rep, 2018 May 18. PMID 29777134, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables integrin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within cell adhesion IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    intercellular adhesion molecule 1; intercellular adhesion molecule 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007114.7 Reference GRCz11 Primary Assembly

      Range
      54776171..54792813
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_068219441.1 → XP_068075542.1  intercellular adhesion molecule 2 isoform X1

    2. XM_001921980.8 → XP_001922015.4  intercellular adhesion molecule 1 isoform X2

      UniProtKB/TrEMBL
      A0A8M1QR11, F6PEJ8
      Related
      ENSDARP00000116079.2, ENSDART00000142710.3
      Conserved Domains (3) summary
      cd05755
      Location:109 → 209
      Ig2_ICAM-1_like; Second immunoglobulin (Ig)-like domain of intercellular cell adhesion molecule-1 (ICAM-1, CD54) and similar proteins
      smart00410
      Location:230 → 281
      IG_like; Immunoglobulin like
      pfam13895
      Location:217 → 281
      Ig_2; Immunoglobulin domain
    Nucleotide Protein
    Heading Accession and Version

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