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    FN1 fibronectin 1 [ Equus caballus (horse) ]

    Gene ID: 100034189, updated on 24-Nov-2024

    Summary

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    Official Symbol
    FN1provided by VGNC
    Official Full Name
    fibronectin 1provided by VGNC
    Primary source
    VGNC:VGNC:56555
    See related
    Ensembl:ENSECAG00000000701
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Equus caballus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus
    Also known as
    FN
    Orthologs
    human mouse all
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    Genomic context

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    See FN1 in Genome Data Viewer
    Location:
    chromosome: 6
    Exon count:
    46
    Annotation release Status Assembly Chr Location
    RS_2024_08 current EquCab3.0 (GCF_002863925.1) 6 NC_009149.3 (5257324..5322790, complement)

    Chromosome 6 - NC_009149.3Genomic Context describing neighboring genes Neighboring gene ATP binding cassette subfamily A member 12 Neighboring gene 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase Neighboring gene uncharacterized LOC111773827 Neighboring gene melanoregulin Neighboring gene transmembrane protein 169 Neighboring gene peroxisomal trans-2-enoyl-CoA reductase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_009149.3 Chromosome 6 Reference EquCab3.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Osteopontin and fibronectin levels are decreased in vitreous of autoimmune uveitis and retinal expression of both proteins indicates ECM re-modeling. Deeg CA, et al. PLoS One, 2011. PMID 22194789, Free PMC Article
    2. Fibronectin mRNA splice variant in articular cartilage lacks bases encoding the V, III-15, and I-10 protein segments. MacLeod JN, et al. J Biol Chem, 1996 Aug 2. PMID 8702559
    3. Annotation of the Protein Coding Regions of the Equine Genome. Hestand MS, et al. PLoS One, 2015. PMID 26107351, Free PMC Article
    4. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    5. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The expression of extracellular matrix molecules fibronectin and osteopontin in vitreous and retina samples in autoimmune uveitis was investigated.
      Title: Osteopontin and fibronectin levels are decreased in vitreous of autoimmune uveitis and retinal expression of both proteins indicates ECM re-modeling.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables extracellular matrix structural constituent IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables integrin binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables proteoglycan binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cell-matrix adhesion IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in cell-substrate junction assembly IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in heart development IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in nervous system development IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    fibronectin

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001434662.1 → NP_001421591.1  fibronectin precursor

      Status: VALIDATED

      Source sequence(s)
      PJAA01000007

    RefSeqs of Annotated Genomes: GCF_002863925.1-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference EquCab3.0 Primary Assembly

    Genomic

    1. NC_009149.3 Reference EquCab3.0 Primary Assembly

      Range
      5257324..5322790 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_023642285.1 → XP_023498053.1  fibronectin isoform X7

      UniProtKB/TrEMBL
      A0A3Q2H4P9
      Conserved Domains (6) summary
      smart00059
      Location:353 → 401
      FN2; Fibronectin type 2 domain
      smart00058
      Location:2169 → 2213
      FN1; Fibronectin type 1 domain
      cd00061
      Location:2257 → 2296
      FN1; Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces ...
      cd00063
      Location:1867 → 1947
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam00039
      Location:231 → 270
      fn1; Fibronectin type I domain
      pfam00041
      Location:1540 → 1621
      fn3; Fibronectin type III domain

    2. XM_023642290.1 → XP_023498058.1  fibronectin isoform X11

      UniProtKB/TrEMBL
      A0A3Q2H4P9
      Related
      ENSECAP00000028263.2, ENSECAT00000065342.3
      Conserved Domains (6) summary
      smart00059
      Location:353 → 401
      FN2; Fibronectin type 2 domain
      smart00058
      Location:2085 → 2126
      FN1; Fibronectin type 1 domain
      cd00061
      Location:2128 → 2167
      FN1; Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces ...
      cd00063
      Location:1995 → 2075
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam00039
      Location:231 → 270
      fn1; Fibronectin type I domain
      pfam00041
      Location:1540 → 1621
      fn3; Fibronectin type III domain

    3. XM_023642284.1 → XP_023498052.1  fibronectin isoform X6

      UniProtKB/TrEMBL
      A0A3Q2H4P9
      Conserved Domains (6) summary
      smart00059
      Location:353 → 401
      FN2; Fibronectin type 2 domain
      smart00058
      Location:2177 → 2221
      FN1; Fibronectin type 1 domain
      cd00061
      Location:2265 → 2304
      FN1; Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces ...
      cd00063
      Location:1995 → 2075
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam00039
      Location:231 → 270
      fn1; Fibronectin type I domain
      pfam00041
      Location:1540 → 1621
      fn3; Fibronectin type III domain

    4. XM_023642280.1 → XP_023498048.1  fibronectin isoform X2

      UniProtKB/TrEMBL
      A0A3Q2H4P9
      Conserved Domains (6) summary
      smart00059
      Location:353 → 401
      FN2; Fibronectin type 2 domain
      smart00058
      Location:2272 → 2316
      FN1; Fibronectin type 1 domain
      cd00061
      Location:2360 → 2399
      FN1; Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces ...
      cd00063
      Location:1995 → 2075
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam00039
      Location:231 → 270
      fn1; Fibronectin type I domain
      pfam00041
      Location:1540 → 1621
      fn3; Fibronectin type III domain

    5. XM_001489104.6 → XP_001489154.5  fibronectin isoform X1

      UniProtKB/Swiss-Prot
      F7CS60, Q28377, Q28378
      UniProtKB/TrEMBL
      A0A3Q2H4P9
      Related
      ENSECAP00000005223.2, ENSECAT00000007204.4
      Conserved Domains (5) summary
      smart00059
      Location:353 → 401
      FN2; Fibronectin type 2 domain
      smart00058
      Location:2297 → 2341
      FN1; Fibronectin type 1 domain
      cd00061
      Location:2385 → 2424
      FN1; Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces ...
      cd00063
      Location:1995 → 2075
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam00041
      Location:1540 → 1621
      fn3; Fibronectin type III domain

    6. XM_023642287.1 → XP_023498055.1  fibronectin isoform X9

      UniProtKB/TrEMBL
      A0A3Q2H4P9
      Conserved Domains (6) summary
      smart00059
      Location:353 → 401
      FN2; Fibronectin type 2 domain
      smart00058
      Location:2091 → 2135
      FN1; Fibronectin type 1 domain
      cd00061
      Location:2179 → 2218
      FN1; Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces ...
      cd00063
      Location:1814 → 1894
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam00039
      Location:231 → 270
      fn1; Fibronectin type I domain
      pfam00041
      Location:1449 → 1530
      fn3; Fibronectin type III domain

    7. XM_023642283.1 → XP_023498051.1  fibronectin isoform X5

      UniProtKB/TrEMBL
      A0A3Q2H4P9
      Conserved Domains (6) summary
      smart00059
      Location:353 → 401
      FN2; Fibronectin type 2 domain
      smart00058
      Location:2181 → 2225
      FN1; Fibronectin type 1 domain
      cd00061
      Location:2269 → 2308
      FN1; Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces ...
      cd00063
      Location:1904 → 1984
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam00039
      Location:231 → 270
      fn1; Fibronectin type I domain
      pfam00041
      Location:1449 → 1530
      fn3; Fibronectin type III domain

    8. XM_023642282.1 → XP_023498050.1  fibronectin isoform X4

      UniProtKB/TrEMBL
      A0A3Q2H4P9, F7CN11
      Related
      ENSECAP00000005228.2, ENSECAT00000007210.4
      Conserved Domains (6) summary
      smart00059
      Location:353 → 401
      FN2; Fibronectin type 2 domain
      smart00058
      Location:2206 → 2250
      FN1; Fibronectin type 1 domain
      cd00061
      Location:2294 → 2333
      FN1; Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces ...
      cd00063
      Location:1904 → 1984
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam00039
      Location:231 → 270
      fn1; Fibronectin type I domain
      pfam00041
      Location:1449 → 1530
      fn3; Fibronectin type III domain

    9. XM_023642289.1 → XP_023498057.1  fibronectin isoform X10

      UniProtKB/TrEMBL
      A0A3Q2H4P9
      Conserved Domains (6) summary
      smart00059
      Location:353 → 401
      FN2; Fibronectin type 2 domain
      smart00058
      Location:2087 → 2131
      FN1; Fibronectin type 1 domain
      cd00061
      Location:2175 → 2214
      FN1; Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces ...
      cd00063
      Location:1905 → 1985
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam00039
      Location:231 → 270
      fn1; Fibronectin type I domain
      pfam00041
      Location:1540 → 1621
      fn3; Fibronectin type III domain

    10. XM_023642281.1 → XP_023498049.1  fibronectin isoform X3

      UniProtKB/TrEMBL
      A0A3Q2H4P9, F7CN05
      Related
      ENSECAP00000005229.2, ENSECAT00000007212.4
      Conserved Domains (6) summary
      smart00059
      Location:353 → 401
      FN2; Fibronectin type 2 domain
      smart00058
      Location:2207 → 2251
      FN1; Fibronectin type 1 domain
      cd00061
      Location:2295 → 2334
      FN1; Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces ...
      cd00063
      Location:1905 → 1985
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam00039
      Location:231 → 270
      fn1; Fibronectin type I domain
      pfam00041
      Location:1540 → 1621
      fn3; Fibronectin type III domain

    11. XM_023642291.1 → XP_023498059.1  fibronectin isoform X12

      UniProtKB/TrEMBL
      A0A3Q2H4P9
      Conserved Domains (6) summary
      smart00059
      Location:353 → 401
      FN2; Fibronectin type 2 domain
      smart00058
      Location:1996 → 2040
      FN1; Fibronectin type 1 domain
      cd00061
      Location:2084 → 2123
      FN1; Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces ...
      cd00063
      Location:1814 → 1894
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam00039
      Location:231 → 270
      fn1; Fibronectin type I domain
      pfam00041
      Location:1449 → 1530
      fn3; Fibronectin type III domain

    12. XM_023642286.1 → XP_023498054.1  fibronectin isoform X8

      UniProtKB/TrEMBL
      A0A3Q2H4P9
      Conserved Domains (6) summary
      smart00059
      Location:353 → 401
      FN2; Fibronectin type 2 domain
      smart00058
      Location:2116 → 2160
      FN1; Fibronectin type 1 domain
      cd00061
      Location:2204 → 2243
      FN1; Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces ...
      cd00063
      Location:1814 → 1894
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam00039
      Location:231 → 270
      fn1; Fibronectin type I domain
      pfam00041
      Location:1449 → 1530
      fn3; Fibronectin type III domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q28377.3 GenPept UniProtKB/Swiss-Prot:Q28377

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