RNA-dependent serine/threonine protein kinase PKR overexpression (Mu11K-A)
Summary:
Analysis of gene expression in NIH3T3 overexpressing RNA-dependent serine/threonine protein kinase (PKR) controlled by a tetracycline repressible promoter. PKR repressed in 1 ug/ml tetracycline and overexpressed upon tetracycline removal. PKR promotes cell survival before inducing cell death.
Donzé O, Deng J, Curran J, Sladek R et al. The protein kinase PKR: a molecular clock that sequentially activates survival and death programs. EMBO J 2004 Feb 11;23(3):564-71. PMID: 14749731
