Sirtuin-1 deficiency effect on adult secondary neurospheres
Summary:
Analysis of adult secondary neurospheres derived from hippocampal neural stem cells/neural progenitor cells of sirtuin-1 knockout mice. Sirt1 is a nicotinamide adenine dinucleotide (NAD)-dependent histone deacetylase. Results provide insight into the role of Sirt1 in adult hippocampal neurogenesis.
Ma CY, Yao MJ, Zhai QW, Jiao JW et al. SIRT1 suppresses self-renewal of adult hippocampal neural stem cells. Development 2014 Dec;141(24):4697-709. PMID: 25468938
