Survival motor neuron deficiency effect on axonal compartment of cultured motoneurons
Summary:
Analysis of the axonal compartment of cultured motoneurons depleted for survival motor neuron (Smn). Smn is the protein deficient in spinal muscular atrophy (SMA). Results provide insight into the axonal mRNA content of degenerating motoneurons in vitro.
Saal L, Briese M, Kneitz S, Glinka M et al. Subcellular transcriptome alterations in a cell culture model of spinal muscular atrophy point to widespread defects in axonal growth and presynaptic differentiation. RNA 2014 Nov;20(11):1789-802. PMID: 25246652
