Drug efflux transporter ABCB5 knockdown effect on A375 melanoma cells
Summary:
Analysis of nonpigmented melanoma A375 cell line following ABCB5 ablation. ABCB5 [ATP-binding cassette, subfamily B (MDR/TAP), member 5] is a drug efflux transporter shown to be highly overexpressed in diverse human cancers. Results provide insight into the role of ABCB5 in melanoma.
GPL571:
[HG-U133A_2] Affymetrix Human Genome U133A 2.0 Array
Citation:
Wilson BJ, Saab KR, Ma J, Schatton T et al. ABCB5 maintains melanoma-initiating cells through a proinflammatory cytokine signaling circuit. Cancer Res 2014 Aug 1;74(15):4196-207. PMID: 24934811
