Nuclear hormone receptor NR4A1 deficiency effect on FHH model of hypertension-associated renal disease: time course
Summary:
Analysis of kidney from 8-24 week-old, Nr4a1-deficient (Nr4a1−/−) animals developed on the genetic background of the Fawn-Hooded Hypertensive (FHH) rat. The FHH model is susceptible to kidney injury. Results provide insight into the role of Nr4a1 in the pathogenesis of kidney disease.
GPL6247:
[RaGene-1_0-st] Affymetrix Rat Gene 1.0 ST Array [transcript (gene) version]
Citation:
Westbrook L, Johnson AC, Regner KR, Williams JM et al. Genetic susceptibility and loss of Nr4a1 enhances macrophage-mediated renal injury in CKD. J Am Soc Nephrol 2014 Nov;25(11):2499-510. PMID: 24722447
