N-nitrosodiethylamine effect on high mobility group N 1 chromosomal protein-deficient liver
Summary:
Analysis of liver from Hmgn1-/- mutants injected with N-nitrosodiethylamine (DEN). HMGN1 is a nucleosome-binding protein affecting chromatin structure/function. Results provide insight into molecular mechanisms underlying accelerated progression of DEN-induced hepatocarcinogenesis in HMGN1 mutants.
Postnikov YV, Furusawa T, Haines DC, Factor VM et al. Loss of the nucleosome-binding protein HMGN1 affects the rate of N-nitrosodiethylamine-induced hepatocarcinogenesis in mice. Mol Cancer Res 2014 Jan;12(1):82-90. PMID: 24296759
