Models of rhabdomyosarcoma and undifferentiated pleomorphic sarcoma
Summary:
Analysis of MyoD-derived sarcomas derived from MDKP (MyoDCE/+; LSL-KrasG12D/+;Trp53Fl/Fl) mice and histological variants (UPS, pleomorphic RMS, and embryonal RMS) from P7KP (Pax7CE/+;LSL-KrasG12D/+;Trp53Fl/Fl) mice. Results provide insight into molecular differences underlying the sarcoma subtypes.
Blum JM, Añó L, Li Z, Van Mater D et al. Distinct and overlapping sarcoma subtypes initiated from muscle stem and progenitor cells. Cell Rep 2013 Nov 27;5(4):933-40. PMID: 24239359