Peroxisome proliferator-γ coactivator-1α deficiency effect on aged gastrocnemius muscle
Summary:
Analysis of muscle from aged animals with muscle-specific Pgc-1α depletion. PGC-1alpha is a transcriptional coactivator of the mitochondrial gene program. Results provide insight into the role of Pgc-1α in the glucose intolerance and chronic systemic inflammation associated with aging.
Sczelecki S, Besse-Patin A, Abboud A, Kleiner S et al. Loss of Pgc-1α expression in aging mouse muscle potentiates glucose intolerance and systemic inflammation. Am J Physiol Endocrinol Metab 2014 Jan 15;306(2):E157-67. PMID: 24280126
