COP1 depletion effect on hepatocellular carcinoma cell lines
Summary:
Analysis of Huh7, HepG2, and Hep3B hepatocellular carcinoma (HCC) cells depleted for the ubiquitin modulator COP1. COP1 regulates p53 activity by ubiquitination. p53 is wild type in HepG2, mutated in Huh7, and lacking in Hep3B. Results provide insight into the role of COP1 in HCC pathogenesis.
Lee YH, Andersen JB, Song HT, Judge AD et al. Definition of ubiquitination modulator COP1 as a novel therapeutic target in human hepatocellular carcinoma. Cancer Res 2010 Nov 1;70(21):8264-9. PMID: 20959491
